公开(公告)号：WO2010014218A2

公开(公告)日：2010-02-04

申请号：PCT/US2009004373

申请日：2009-07-29

Applicant: ACADEMIA SINICA ,  YU JOHN ,  YU ALICE ,  KUO MING-WEI ,  CHANG JUI-CHIN

Inventor： YU JOHN ,  YU ALICE ,  KUO MING-WEI ,  CHANG JUI-CHIN

IPC: C12N15/09

CPC classification number: C07K14/4747 ,  A61K48/005 ,  C07K16/18 ,  C12N15/113 ,  C12N2799/025 ,  C12Q1/6876 ,  G01N33/6854

Abstract: Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.

Abstract translation: 用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。 提供载体，包括包含治疗化合物的AAV载体。 提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。 提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

公开(公告)号：ES2818948T3

公开(公告)日：2021-04-14

申请号：ES14886988

申请日：2014-10-28

Applicant: DEV CT BIOTECHNOLOGY ,  CHANG GUNG MEMORIAL HOSPITAL ,  ACADEMIA SINICA

Inventor： YU ALICE ,  YU JOHN ,  WANG YA-HUI ,  HSU CHUAN-LUNG ,  CHEN YI-CHANG ,  LOK YING-YUNG

IPC: G01N33/574 ,  C07K16/30

Abstract: Un anticuerpo contra la proteína con dominios de superhélice transmembrana 3 (TMCC3), o un fragmento de unión de la misma, en donde el anticuerpo comprende las siguientes secuencias de CDR: la secuencia de CDRH1 es el SEQ ID NO: 102, la secuencia de CDRH2 es el SEQ ID NO: 226, la secuencia de CDRH3 es el SEQ ID NO: 350, la secuencia de CDRL1 es el SEQ ID NO: 474, la secuencia de CDRL2 es el SEQ ID NO: 598, y la secuencia de CDRL3 es el SEQ ID NO: 722, o la CDRH1 es el SEQ ID NO: 101, la CDRH2 es el SEQ ID NO: 225, la CDRH3 es el SEQ ID NO: 349, la CDRL1 es el SEQ ID NO: 473, la CDRL2 es el SEQ ID NO: 597, y la CDRL3 es el SEQ ID NO: 721.

公开(公告)号：ES2570630T3

公开(公告)日：2016-05-19

申请号：ES09789075

申请日：2009-08-06

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

IPC: A61K39/00 ,  A61K39/385

Abstract: Una composición inmunogénica que comprende: (a) un glicano que consiste esencialmente en Globo H, el antígeno-3 específico de la etapa embrionaria (SSEA-3. Gb5) y el antígeno-4 específico de la etapa embrionaria (SSEA-4, sialil-Gb5), Bb4, o un fragmento inmunogénico del mismo, en el que el glicano que se conjuga con una proteína portadora es el material 197 que presenta reacción cruzada con la toxina de la difteria (DT-CRM197) o el toxoide de la difteria, a través de un enlazante; y (b) un adyuvante de α-galactosil-ceramida (α-GalCer).

公开(公告)号：AU2014201215A1

公开(公告)日：2014-04-03

申请号：AU2014201215

申请日：2014-03-05

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

IPC: A61K39/00 ,  A61K39/385

Abstract: The present invention provides for an immunogenic composition comprising (a) a glycan, such as Globo H, stage-specific embryonic antigen-3 (SSEA-3) or SSEA-4, conjugated to a carrier protein through a linker; (b) an adjuvant comprising a glycolipid, such as a-galactosyl-ceramide adjuvant, wherein the composition induces an immune response, such as a higher relative level of IgG isotype antibodies compared to IgM isotype antibodies, or neutralising antibodies against at least one antigen selected from the group consisting of Globo H, Gb4, SSEA-3, and SSEA-4. Uses of the immunogenic composition for treating or inhibiting tumour growth are also provided.

公开(公告)号：AU2009269127B2

公开(公告)日：2013-12-05

申请号：AU2009269127

申请日：2009-08-06

Applicant: ACADEMIA SINICA

Inventor： YU ALICE ,  WONG CHI-HUEY ,  YU JOHN ,  WU CHUNG-YI

IPC: A61K39/00 ,  A61K39/385

Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CDId on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM 197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM 197.

公开(公告)号：CA2728344A1

公开(公告)日：2010-01-14

申请号：CA2728344

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  YU JOHN ,  WONG CHI-HUEY

IPC: A61K31/716 ,  A61K31/164 ,  A61K31/7008 ,  A61P35/00

Abstract: An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., a -GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis.

公开(公告)号：AU2009269127A1

公开(公告)日：2010-01-14

申请号：AU2009269127

申请日：2009-08-06

Applicant: ACADEMIA SINICA

Inventor： YU ALICE ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  YU JOHN

IPC: A61K39/00 ,  A61K39/385

Abstract: An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4 (SSEA-4), wherein the glycan is conjugated with the carrier protein through a linker.

公开(公告)号：EP2303286A4

公开(公告)日：2011-12-28

申请号：EP09794927

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  YU JOHN ,  WONG CHI-HUEY

IPC: A61K31/716 ,  A61K31/164 ,  A61K31/7008 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

公开(公告)号：EP2632939A4

公开(公告)日：2014-05-14

申请号：EP11838514

申请日：2011-10-25

Applicant: ACADEMIA SINICA TAIWAN ,  YU JOHN ,  YU ALICE ,  WU H C ,  WANG SHENG-HUNG ,  I-JU CHEN

Inventor： YU JOHN ,  YU ALICE ,  WU H C ,  WANG SHENG-HUNG ,  I-JU CHEN

IPC: C07K5/10 ,  A61K38/07 ,  A61K38/10 ,  A61K49/14 ,  A61P35/00 ,  C07K7/08

CPC classification number: G06F19/16 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/337 ,  A61K31/475 ,  A61K31/496 ,  A61K31/704 ,  A61K38/10 ,  A61K45/06 ,  A61K47/48815 ,  A61K47/6911 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/1234 ,  C07K5/1024 ,  C07K7/08 ,  G01N2333/47 ,  G01N2500/04 ,  A61K2300/00

公开(公告)号：EP1804584A4

公开(公告)日：2009-08-05

申请号：EP05810080

申请日：2005-10-14

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  HSU HSIEN-YEH ,  HUA KUO-FENG ,  LIN CHUN-HUNG ,  HSU JASON ,  CHEN SHUI-TEIN ,  LIN KUO-I ,  YANG WEN-BIN ,  YU JOHN ,  YU ALICE

IPC: A01N65/00

CPC classification number: A61K36/074

Abstract: A fucose-containing glycoprotein fraction obtainable from an extract of