公开(公告)号：EP2995325A4

公开(公告)日：2016-12-21

申请号：EP14794303

申请日：2014-05-02

Applicant: NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  ADEKA CORP

Inventor： KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00

CPC classification number: A61L27/3691 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2430/34 ,  C12M25/14 ,  C12N5/0081 ,  C12N2521/00

Abstract: A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration.

公开(公告)号：EP2995326A4

公开(公告)日：2017-01-11

申请号：EP14795291

申请日：2014-05-02

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

CPC classification number: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

Abstract translation: 一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含该混合凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。 本发明的混合凝胶发挥促进干细胞分化和功能增强的效果以及对各种疾病的治疗效果。

公开(公告)号：EP2671905A4

公开(公告)日：2014-11-12

申请号：EP11847881

申请日：2011-11-15

Applicant: ADEKA CORP

Inventor： HIWATARI KEN-ICHIRO ,  SAIKI TOMOAKI

IPC: C08G77/388 ,  C08L83/04 ,  C08L83/08

CPC classification number: C08G77/388 ,  C08G77/12 ,  C08G77/50 ,  C08G77/80 ,  C08L83/00 ,  C09J183/14 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The present invention provides a compound that is excellent in thermal resistance and compatibility with resins, and can sufficiently improve the thermal resistance of the resins, and specifically provides a compound represented by the following general formula (1). In the formula (1), R 1 to R 4 each represent a C1-12 alkyl group or a C6-12 aryl group, y represents a number of from 1 to 2,000, and X 1 represents a group represented by the formula (2) or (3). In the formula (2), R 5 represents a hydrogen atom, O·, a C1-12 alkyl group or a C1-12 alkoxy group, L 1 represents a C1-6 alkylene group or a C6-12 arylene group. In the formula (3), R 6 represents a C1-4 alkyl group or a C6-12 aryl group, X 2 represents a group represented by the formula (2) or a hydrogen atom, s represents a number of from 2 to 6, L 2 represents a C1-6 alkylene group or a C6-12 arylene group, and at least one of s number of X 2 s is the group represented by the formula (2).

公开(公告)号：EP2599836A4

公开(公告)日：2014-02-26

申请号：EP11799224

申请日：2011-05-26

Applicant: ADEKA CORP

Inventor： HIWATARI KEN-ICHIRO ,  YUMOTO ISAMU

IPC: C08L83/05 ,  C08L83/07 ,  H01L23/29 ,  H01L23/31

CPC classification number: H01L23/296 ,  C08G77/12 ,  C08G77/20 ,  C08G77/50 ,  C08G77/80 ,  C08L83/14 ,  H01L2924/0002 ,  H01L2924/12044 ,  Y10T428/31663 ,  C08L83/00 ,  H01L2924/00

公开(公告)号：EP2141188A4

公开(公告)日：2010-08-04

申请号：EP08740710

申请日：2008-04-21

Applicant: ADEKA CORP

Inventor： SUEYOSHI TAKASHI ,  HIWATARI KEN-ICHIRO ,  JANADO TADASHI ,  SHOJI YOSHIKAZU ,  SAITO SEIICHI ,  SUGAWARA YOSHITAKA

IPC: C08G77/50 ,  C08K3/20 ,  C08K3/36 ,  C08L83/05 ,  C08L83/07 ,  C08L83/14

CPC classification number: C08G77/50 ,  C08L83/14 ,  C08L83/00