公开(公告)号：EP2344505A2

公开(公告)日：2011-07-20

申请号：EP09793046.5

申请日：2009-09-28

Applicant: Abbott Laboratories

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana ,  HU, Min

IPC: C07D487/18 ,  A61K31/33 ,  A61P25/00

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R
1 , R
2 , R
3 , R
4 , R
5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：EP2038278A2

公开(公告)日：2009-03-25

申请号：EP07812349.4

申请日：2007-06-27

Applicant: ABBOTT LABORATORIES

Inventor： FAGHIH, Ramin ,  GFESSER, Gregory A. ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali ,  GOPALAKRISHNAN, Sujatha ,  MALYSZ, John ,  GUBBINS, Earl J. ,  EL KOUHEN, Rachid ,  LI, Jinhe ,  SARRIS, Kathy A. ,  MICHMERHUIZEN, Melissa J. ,  WANG, Ying

IPC: C07D417/04 ,  C07D413/04 ,  C07D417/14 ,  A61K31/422 ,  A61K31/427

CPC classification number: C07D417/04 ,  C07D413/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.