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公开(公告)号：EP2240483B1
公开(公告)日：2013-02-27
申请号：EP09700747.0
申请日：2009-01-09
Applicant: Array Biopharma, Inc. , Banka, Anna , Bencsik, Josef R. , Blake, James F. , Fong, Kin Chiu , Hentemann, Martin F. , Mitchell, Ian S. , Sammond, Douglas McCord , Tang, Tony P. , Wallace, Eli M. , Xu, Rui
Inventor： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , FONG, Kin Chiu , HENTEMANN, Martin F. , MITCHELL, Ian S. , SAMMOND, Douglas McCord , TANG, Tony P. , WALLACE, Eli M. , XU, Rui , GRAHAM, James
IPC: C07D471/10 , C07D487/10 , A61K31/517 , A61K31/438 , A61P35/00
CPC classification number: C07D471/10 , C07D487/10
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公开(公告)号：EP2242757A1
公开(公告)日：2010-10-27
申请号：EP09701216.5
申请日：2009-01-08
Applicant: Array Biopharma, Inc.
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/4162 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2242757B1
公开(公告)日：2012-08-01
申请号：EP09701216.5
申请日：2009-01-08
Applicant: Array Biopharma, Inc.
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/4162 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2242755A1
公开(公告)日：2010-10-27
申请号：EP09700828.8
申请日：2009-01-08
Applicant: Array Biopharma, Inc.
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/496 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Formula, (I).
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15.发明公开PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 有权吡啶-2-基氨基-I，2，4 -THIADIAZOLDERIVATE ALS葡糖激酶活化剂治疗糖尿病
公开(公告)号：EP2209778A1
公开(公告)日：2010-07-28
申请号：EP08834504.6
申请日：2008-09-15
Applicant: Array Biopharma, Inc.
Inventor： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
IPC: C07D417/12 , C07D417/14 , A61K31/433 , A61P3/10
CPC classification number: C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
Abstract: Provided are compounds of Formula (I): wherein R
2 , R
3 , R
13 , L and D
2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.-
Patent Agency Ranking
公开(公告)号：EP1879886A1
公开(公告)日：2008-01-23
申请号：EP06758821.0
申请日：2006-05-01
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk , VOEGTLI, Walter Charles
IPC: C07D417/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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17.发明公开MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权MITOTISCHE KINESINHEMMER UND VERFAHREN ZU IHRER VERWENDUNG
公开(公告)号：EP1809280A2
公开(公告)日：2007-07-25
申请号：EP05819172.7
申请日：2005-10-18
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , LYSSIKATOS, Joseph P. , AICHER, Tom , LAIRD, Ellen , ROBINSON, John , ALLEN, Shelley
IPC: A61K31/4245 , C07D417/00 , C07D413/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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18.发明授权
公开(公告)号：EP2250155B1
公开(公告)日：2013-07-03
申请号：EP09701043.3
申请日：2009-01-09
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , HENTEMANN, Martin F. , KALLAN, Nicholas C. , LIANG, Jun , MITCHELL, Ian S. , SCHLACHTER, Stephen T. , WALLACE, Eli M. , XU, Rui , TANG, Tony, P.
IPC: C07D239/70 , A61K31/517 , A61P35/00 , C07D401/04 , C07D401/10 , C07D409/04 , C07D417/04 , C07D487/04
CPC classification number: C07D401/10 , C07D211/08 , C07D211/46 , C07D239/70 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D409/04 , C07D417/04 , C07D417/10 , C07D487/04
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19.发明授权
公开(公告)号：EP2240483B8
公开(公告)日：2013-04-03
申请号：EP09700747.0
申请日：2009-01-09
Applicant: Array Biopharma, Inc.
Inventor： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , FONG, Kin Chiu , HENTEMANN, Martin F. , MITCHELL, Ian S. , SAMMOND, Douglas McCord , TANG, Tony P. , WALLACE, Eli M. , XU, Rui , GRAHAM, James
IPC: C07D471/10 , C07D487/10 , A61K31/517 , A61K31/438 , A61P35/00
CPC classification number: C07D471/10 , C07D487/10
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公开(公告)号：EP2242755B1
公开(公告)日：2012-09-12
申请号：EP09700828.8
申请日：2009-01-08
Applicant: Array Biopharma, Inc.
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/496 , A61P35/00
CPC classification number: C07D471/04
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