公开(公告)号：JPH0868694A

公开(公告)日：1996-03-12

申请号：JP19314795

申请日：1995-07-28

Applicant: BASF AG

Inventor： TOOMASU FURIIDORITSUHI ,  DEIITAA HORUN ,  YURUGEN KURINGURAA ,  HARUMU BUIIZE

IPC: G01J3/457 ,  G01N21/64 ,  G01P5/22

Abstract: PROBLEM TO BE SOLVED: To provide a fluorescent correlation spectroscopically analyzing method and device with a small observation space volume as required, which is simple and movable to allow observation in an area, hard to approach. SOLUTION: In a fluorescent correlation spectroscopically analyzing method and device to allow the observation of drift velocity, diffusion coefficient and volume shrinkage, excited light emitted from a light source 1 is guided to a fiber coupler 3 via the first optical fiber wave guide 2 and then to specimen 6 via the second optical fiber wave guide 4 and fluorescent light emitted from specimen particles is guided to the fiber coupler 3 via the second optical fiber wave guide 4 and then to a detector 10 via the third optical fiber wave guide 8.

公开(公告)号：JPH07163862A

公开(公告)日：1995-06-27

申请号：JP20723994

申请日：1994-08-31

Applicant: BASF AG

Inventor： RUTSU ENTO ,  DEIITAA HORUN ,  ERITSUKU RIYUDETSUKE

IPC: B01J13/04 ,  A61K9/14 ,  A61K9/16 ,  B01F17/00 ,  B01J2/04 ,  B01J2/06 ,  B01J13/00 ,  C09B61/00 ,  C09B67/00 ,  C09B67/42 ,  C09B67/46

Abstract: PURPOSE: To provide an improved method to obtain a very fine particle of water-insoluble dye or drug by using a least amount of solvent. CONSTITUTION: In a process for producing a fine-particle, essentially amorphous dye or drug preparation by converting a relatively coarse-particle dispersion or an organic solution into a colloidal dispersion phase in water, the colloidal dispersion of dye or drug, or the organic solution is mixed and stirred with water or aqueous protective colloid solution at a temperature higher than a melting point of the dye or the drug, or under pressure at need. The obtained melting emulsion is immediately spray-dried or converted into a suspension by cooling.

公开(公告)号：JPS63196242A

公开(公告)日：1988-08-15

申请号：JP1104788

申请日：1988-01-22

Applicant: BASF AG

Inventor： DEIITAA HORUN ,  ERIIKU RIYUUDODETSUKE ,  PEETAA SHIEEFUAA

IPC: A23K1/16 ,  A23L1/275 ,  A23L5/44 ,  B01F3/00 ,  C07C403/00 ,  C09B61/00

公开(公告)号：JPS62240364A

公开(公告)日：1987-10-21

申请号：JP6815187

申请日：1987-03-24

Applicant: BASF AG

Inventor： ERIIKU RIYUUTODETSUKE ,  DEIITAA HORUN

IPC: A23K1/16 ,  A23L1/275 ,  A23L5/44 ,  A61K9/14 ,  C09B61/00 ,  C09B67/20 ,  C09B67/42

公开(公告)号：JPH09113448A

公开(公告)日：1997-05-02

申请号：JP23227196

申请日：1996-09-02

Applicant: BASF AG

Inventor： BUORUFUGANGU SHIYUROFU ,  YURUGEN KURINGAA ,  DEIITAA HORUN ,  ERUMAARU MAIAA

IPC: G01N21/64

Abstract: PROBLEM TO BE SOLVED: To realize quick inspection of a sample at low cost by bounding or defining a plurality of focusing regions in an equipment such that a sample arranged in a focusing region is pumped with only one laser and the samples are observed in parallel thereby inspecting the entirety with only one laser. SOLUTION: Light from a pulse laser 1 is introduced through the objective lenses 2a, 2b, 2n of microscope and measuring cells 3a, 3b, 3n before being focused. A sample is set in each focusing region 6a, 6b, 6n. Particle fluorescence in the sample is detected by optically focusing on photomultiplier tubes 7a, 7b, 7n through lenses 4a, 4b, 4n. Filters 5a, 5b, 5n are fixed in front of the multiplier tubes 7a, 7b, 7n. Information from the multiplier tubes 7a, 7b, 7n is introduced to an evaluation electronic unit 8 and processed. A measuring method for determining the diffusion characteristics of particles labeled by fluorescence can be carried out in parallel.

公开(公告)号：JPH04247028A

公开(公告)日：1992-09-03

申请号：JP24863891

申请日：1991-09-27

Applicant: BASF AG

Inventor： RUTSUTSU ENTO ,  DEIITAA HORUN ,  EERIKU RIYUUTODETSUKE ,  YOAHIMU UU SHIYUNAIDAA ,  PEETAA PAURU HOTSUPE ,  FURIIDORITSUHIIBUIRUHERUMU REN

IPC: A61K9/08 ,  A61K9/00 ,  A61K9/107 ,  A61K31/015 ,  A61K31/07 ,  A61K47/14 ,  A61P15/00 ,  B01F3/08 ,  B01F17/00 ,  C07B63/04 ,  C07C403/24

Abstract: PURPOSE: To provide a method for continuously producing β-carotene solubilizate by selecting a dissolution temperature and a retention time. CONSTITUTION: In this method for continuously producing β-carotene solubilizate by heating β-carotene with an emulsifying agent in a short time to give a homogeneous solution, quickly cooling the solution to

公开(公告)号：JPH03151326A

公开(公告)日：1991-06-27

申请号：JP28735690

申请日：1990-10-26

Applicant: BASF AG

Inventor： DEIITAA HORUN ,  RUTSUTSU ENDO ,  RAINHARUTO SHIYUPENGURAA ,  HANSUUYURUGEN KURAUZE ,  YURUGEN ERUTSUNAA

IPC: A61K9/14 ,  A61K9/50 ,  A61K38/00 ,  C07K1/00 ,  C07K14/52 ,  C07K14/555 ,  C07K14/57 ,  C07K14/705 ,  C07K14/81

Abstract: PURPOSE: To stabilize a peptide bond against the hydrolysis or decomposition with an enzyme and improve the bioavailability by micronizing a pharmaceutical agent having the peptide bond according to a specific method. CONSTITUTION: A pharmaceutical agent having a peptide bond, as necessary, together with a surfactant, is dissolved in a volatile water-miscible organic solvent (the one, miscible with water to at least 10%, boiling at

公开(公告)号：JPH0261998B2

公开(公告)日：1990-12-21

申请号：JP20776782

申请日：1982-11-29

Applicant: BASF AG

Inventor： KAARUUHAINTSU ETSUTSUBATSUHA ,  FURITSUTSU GURAAZAA ,  DEIITAA HORUN ,  WARUTAA DEITSUTAA

IPC: C07D519/00 ,  C09B5/62 ,  C09K19/60 ,  G02F1/13

公开(公告)号：JPS63192715A

公开(公告)日：1988-08-10

申请号：JP1104888

申请日：1988-01-22

Applicant: BASF AG

Inventor： DEIITAA HORUN ,  RAINHARUTO SHIYUPENGURAA

IPC: A61K9/14 ,  A61K9/10 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00

公开(公告)号：JPS6051507B2

公开(公告)日：1985-11-14

申请号：JP8720978

申请日：1978-07-19

Applicant: BASF AG

Inventor： EEUARUTO DAUBATSUHA ,  DEIITAA HORUN ,  ERUIN HAAN ,  HERUBERUTO UURITSUHI

IPC: C09B67/20 ,  C09B67/06 ,  C09B67/38 ,  D06P1/16