公开(公告)号：CA2341345A1

公开(公告)日：2000-03-02

申请号：CA2341345

申请日：1999-08-13

Applicant: BASF AG

Inventor： DULLY CHRISTIAN ,  DITRICH KLAUS ,  NUBLING CHRISTOPH

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The invention relates to a method for the racemic cleavage of alkoxy- substituted primary amines by reaction with an ester in the presence of a lipase and subsequent separation of the resulting optically active amide fro m the optically active unreacted amine. This is possibly followed by hydrolysi s of the optically active amide, separation of the resulting optically active amine from the acid at the origin of the ester, racemization and recirculati on of the undesirable enantiomer of the amine and esterification and recirculation of the acid.

公开(公告)号：DE19703426A1

公开(公告)日：1998-08-06

申请号：DE19703426

申请日：1997-01-30

Applicant: BASF AG

Inventor： FREDE MARKUS DR ,  DULLY CHRISTIAN ,  DITRICH KLAUS DR ,  MELDER JOHANN-PETER DR ,  WEYER HANS-JUERGEN DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00 ,  C07B63/00 ,  C07B57/00 ,  B01D61/42

Abstract: Purification of alpha , beta , gamma -substituted carboxylic acids of formula (I), their salts and esters or a mixture of these and one or more polyol and one or more aminoalcohol in aqueous solution comprises treatment by electrodialysis. R1 = H, 1-10C alkyl, Na or K ; R2 = H or 1-10C alkyl; R3 = H, 1-10C alkyl (optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo-substituted phenyl); X = halo (when R3 is absent), N, O, P, S; and m = 0-2. Also claimed are: (i) cleavage of an optically active amide to an optically active amine and (I); and (ii) resolution of a racemic primary or secondary amine by reacting (I) with a hydrolase, separating the unreacted enantiomer of the amine from the amide and hydrolysing the amide to give the amine enantiomer and (I).