公开(公告)号：JPH10279520A

公开(公告)日：1998-10-20

申请号：JP1658498

申请日：1998-01-29

Applicant: BASF AG

Inventor： FREDE MARKUS DR ,  DULLY CHRISTIAN ,  DITRICH KLAUS DR ,  MELDER JOHANN-PETER DR ,  WEYER HANS-JUERGEN DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00

Abstract: PROBLEM TO BE SOLVED: To easily purify an α-, β- or γ-substituted carboxylic acid mixture from an aqueous solution by electrodialyzing an aqueous solution containing the mixture and a polyol. SOLUTION: An a-, β- or γ-substituted carboxylic acid is purified from an aqueous solution containing the α-, β- or γ-substituted carboxylic acid, its salt or ester or their mixture and at least one kind of polyol or at least one kind of amino alcohol and optionally a cation of at least one kind of a strong base by electrodialyzing the solution by conventional two-cycle electrodialysis, dipolar two-cycle electrodialysis and/ or dipolar three-cycle electrodialysis.

公开(公告)号：DE19703426A1

公开(公告)日：1998-08-06

申请号：DE19703426

申请日：1997-01-30

Applicant: BASF AG

Inventor： FREDE MARKUS DR ,  DULLY CHRISTIAN ,  DITRICH KLAUS DR ,  MELDER JOHANN-PETER DR ,  WEYER HANS-JUERGEN DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00 ,  C07B63/00 ,  C07B57/00 ,  B01D61/42

Abstract: Purification of alpha , beta , gamma -substituted carboxylic acids of formula (I), their salts and esters or a mixture of these and one or more polyol and one or more aminoalcohol in aqueous solution comprises treatment by electrodialysis. R1 = H, 1-10C alkyl, Na or K ; R2 = H or 1-10C alkyl; R3 = H, 1-10C alkyl (optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo-substituted phenyl); X = halo (when R3 is absent), N, O, P, S; and m = 0-2. Also claimed are: (i) cleavage of an optically active amide to an optically active amine and (I); and (ii) resolution of a racemic primary or secondary amine by reacting (I) with a hydrolase, separating the unreacted enantiomer of the amine from the amide and hydrolysing the amide to give the amine enantiomer and (I).

公开(公告)号：ES2153693T3

公开(公告)日：2001-03-01

申请号：ES98101536

申请日：1998-01-29

Applicant: BASF AG

Inventor： FREDE MARKUS DR ,  DULLY CHRISTIAN ,  DITRICH KLAUS DR ,  MELDER JOHANN-PETER ,  WEYER HANS-JURGEN DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00

Abstract: Purification of alpha , beta , gamma -substituted carboxylic acids of formula (I), their salts and esters or a mixture of these and one or more polyol and one or more aminoalcohol in aqueous solution comprises treatment by electrodialysis. R1 = H, 1-10C alkyl, Na or K ; R2 = H or 1-10C alkyl; R3 = H, 1-10C alkyl (optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo-substituted phenyl); X = halo (when R3 is absent), N, O, P, S; and m = 0-2. Also claimed are: (i) cleavage of an optically active amide to an optically active amine and (I); and (ii) resolution of a racemic primary or secondary amine by reacting (I) with a hydrolase, separating the unreacted enantiomer of the amine from the amide and hydrolysing the amide to give the amine enantiomer and (I).

公开(公告)号：DE59800397D1

公开(公告)日：2001-02-01

申请号：DE59800397

申请日：1998-01-29

Applicant: BASF AG

Inventor： FREDE DR ,  DULLY CHRISTIAN ,  DITRICH DR ,  MELDER JOHANN-PETER ,  WEYER DR ,  WEITZE ACHIM

IPC: C12P41/00 ,  B01D61/44 ,  C07C51/42 ,  C07C51/43 ,  C07C59/125 ,  C07C209/88 ,  C07C211/27 ,  C07C211/29 ,  C25B3/00

Abstract: Purification of alpha , beta , gamma -substituted carboxylic acids of formula (I), their salts and esters or a mixture of these and one or more polyol and one or more aminoalcohol in aqueous solution comprises treatment by electrodialysis. R1 = H, 1-10C alkyl, Na or K ; R2 = H or 1-10C alkyl; R3 = H, 1-10C alkyl (optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo-substituted phenyl); X = halo (when R3 is absent), N, O, P, S; and m = 0-2. Also claimed are: (i) cleavage of an optically active amide to an optically active amine and (I); and (ii) resolution of a racemic primary or secondary amine by reacting (I) with a hydrolase, separating the unreacted enantiomer of the amine from the amide and hydrolysing the amide to give the amine enantiomer and (I).