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    6-ACYLAMINOPHENYL-4,5-DIHYDROPYRIDAZONES
    12.
    发明专利
    6-ACYLAMINOPHENYL-4,5-DIHYDROPYRIDAZONES 未知

    公开(公告)号：CA990296A

    公开(公告)日：1976-06-01

    申请号：CA142033

    申请日：1972-05-10

    Applicant: BASF AG

    Inventor： LEBKUECHER ROLF ,  KOENIG HORST ,  AMANN AUGUST ,  GIERTZ HUBERT ,  SCHUSTER JOERG

    IPC: A61K31/50 ,  C07D237/04 ,  C07D295/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    Abstract: 1386150 6 - Acylaminophenyl - 4,5 - dihydropyridazones BADISCHE ANILINSODAFABRIK AG 10 May 1972 [11 May 1971] 21734/72 Heading C2C Novel 6 - acylamino - 4,5 - dihydropyridazone compounds of general Formula (1): in which R is H or C 1-8 alkyl, and X is an amino or ammonium radical containing directly attached to the N atom at least one C atom but not more than one aromatic ring, and acid addition salts thereof, may be prepared by reacting an amine XH or a trialkylamine with a dihydropyridazone of the Formula (2): which in turn may be prepared by reacting compounds of Formula (4) with compounds of Formula (5) to form compounds of Formula (6) which are then cyclized with hydrazine The novel compounds I exhibit pharmaceutical properties, having the effect of lowering blood pressure, dilating the coronary arteries and combating inflammation.

    CARBAMATES AND THEIR USE AS PHARMACEUTICALS
    14.
    发明专利
    CARBAMATES AND THEIR USE AS PHARMACEUTICALS 未知

    公开(公告)号：CA1071644A

    公开(公告)日：1980-02-12

    申请号：CA286651

    申请日：1977-09-13

    Applicant: BASF AG

    Inventor： AMANN AUGUST ,  BOLZ GERHARD ,  WIERSDORFF WALTER-WIELANT ,  GIERTZ HUBERT ,  WILSMANN KLAUS

    IPC: C07D307/77

    Abstract: This invention is concerned with a process for the production of a new carbamate of the formula I: I, in which the dotted line denotes a double bond which may be hydrogenated, X is an alkylene bridge of 1 or 2 carbon atoms, R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, R3 is hydrogen and R4 is hydrogen, a linear of branched alkyl of 1 to 4 carbon atoms or a phenyl. This process comprises the steps of reacting a diene of the formula V: V, with a dienophile of the formula VI: VI, according to the Diels Alder reaction, at a temperature of from 15.degree. to 220.degree.C, and hydrogenating the double bond of the obtained unsaturated carbamate when desired. The so prepared new carbamate may be used as pharmaceuticals by virtue of their analgesic properties.

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