公开(公告)号：ES2156212T3

公开(公告)日：2001-06-16

申请号：ES95926973

申请日：1995-07-22

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN

IPC: C07D409/12 ,  A61K31/40 ,  A61K31/403 ,  A61P25/18 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/90 ,  C07D209/92 ,  C07D403/06

Abstract: PCT No. PCT/EP95/02912 Sec. 371 Date Feb. 3, 1997 Sec. 102(e) Date Feb. 3, 1997 PCT Filed Jul. 22, 1995 PCT Pub. No. WO96/04245 PCT Pub. Date Feb. 15, 1996A compound of the formula in which A, R1 and n have the meanings stated in the description are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：AU7656700A

公开(公告)日：2001-04-30

申请号：AU7656700

申请日：2000-09-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  SCHULT SABINE

IPC: A61K31/5517 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D487/06 ,  C07D519/00 ,  C07D487/00

公开(公告)号：AU5618699A

公开(公告)日：2000-03-06

申请号：AU5618699

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

公开(公告)号：AU5285599A

公开(公告)日：2000-03-06

申请号：AU5285599

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/00 ,  C07D417/06

Abstract: Compounds of the formula I:in which R1, R2, R3 and R4 have the meanings stated in the description, are described.The novel compounds are suitable for controlling diseases.

公开(公告)号：CA2339986A1

公开(公告)日：2000-02-24

申请号：CA2339986

申请日：1999-07-20

Applicant: BASF AG

Inventor： TESCHENDORF HANS-JURGEN ,  UNGER LILIANE ,  HOGER THOMAS ,  JUCHELKA FRIEDER ,  STEINER GERD

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/00 ,  C07D417/06

Abstract: The invention relates to compounds of formula (I), wherein R1, R2, R3 and R4 have the meaning cited in the description. The novel compounds are suitable for use in disease control.

公开(公告)号：CA2330206A1

公开(公告)日：1999-12-16

申请号：CA2330206

申请日：1999-06-04

Applicant: BASF AG

Inventor： HOGER THOMAS ,  KOCK MICHAEL ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/10 ,  A61K31/70

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologues which are characterised by an amino acid sequence with a) a functional NAD+-binding site and b) no zinc-finger-sequence motif of general formula CX2CXmHX2C, wherein m is an integral number 28 or 30 and the radicals X represent any amino acid, independently of each other; and to the functional equivalents of said poly(ADP-ribose)polymerase (PARP) homologues. The invention also relates to nucleic acids coding the poly(ADP-ribose)polymerase (PARP) homologues, to antibodies with specificity for the novel protein, to pharmaceutical and gene therapy agents containing the inventive products, to methods for analytically determining the inventive proteins and nucleic acids, to methods for identifying the effectors or bonding partners of the inventive proteins, to novel PARP effectors and to methods for determining the effectiveness of effectors of this type.

公开(公告)号：NZ276411A

公开(公告)日：1997-11-24

申请号：NZ27641194

申请日：1994-11-26

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  HOGER THOMAS

IPC: C07D401/04 ,  A61K31/40 ,  A61K31/403 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D209/02 ,  C07D209/46 ,  C07D209/52 ,  C07D209/90 ,  C07D209/96 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/06 ,  C07D413/04 ,  C07D405/04 ,  A61K31/42 ,  A61K31/415 ,  A61K31/535 ,  A61K31/495

Abstract: PCT No. PCT/EP94/03910 Sec. 371 Date Apr. 19, 1996 Sec. 102(e) Date Apr. 19, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15312 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

公开(公告)号：CA2371645C

公开(公告)日：2007-04-17

申请号：CA2371645

申请日：2000-04-27

Applicant: BASF AG

Inventor： MULLER REINHOLD ,  LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  HOLZENKAMP UTA ,  SCHULT SABINE

IPC: C07D235/18 ,  C07D235/20 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D209/00 ,  C07D213/00 ,  C07D235/00 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: The present invention relates to novel benzimidazoles, the production thereo f and the utilisation as inhibitors of the enzyme poly(ADP-ribose)polymerase o r PARP (EC 2.4.2.30) for producing medicaments.

公开(公告)号：CA2177602C

公开(公告)日：2007-01-02

申请号：CA2177602

申请日：1994-11-26

Applicant: BASF AG

Inventor： MUNSCHAUER RAINER ,  UNGER LILIANE ,  STEINER GERD ,  TESCHENDORF HANS-JURGEN ,  HOGER THOMAS

IPC: C07D209/44 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/42 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/14 ,  C07D209/18 ,  C07D209/52 ,  C07D409/12 ,  C07D487/04 ,  C07D491/048 ,  C07D497/04 ,  C07D498/04

Abstract: Compounds of formula (I) where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds ar e suitable for the control of diseases.

公开(公告)号：CA2352554C

公开(公告)日：2006-10-10

申请号：CA2352554

申请日：1999-11-23

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  LUBISCH WILFRIED ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: C07D401/04 ,  A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/14 ,  C07D403/04

Abstract: The invention relates to compounds of general formula (1a) or (1b) wherein R 1 and R4 are hydrogen or defined substituents, A is a saturated or monoethenoid heterocyclic ring with 4 to 8 members which contains one or two nitrogen atoms, wherein additionally one oxygen or sulfur atom can be present. Said ring can be further substituted. The invention also relates to their tautomer forms, possible enantiomer and diastereomer forms, their prodrugs, as well as possible physiologically acceptable salts. The invention also relates to the use of said compounds for treating diseases related to a pathologically increased activity of PARP.