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    Preparation of optically active 3-phenylpropionic acid derivatives, used for preparing halo-phenyl compounds, comprises hydrogenating cis-isomer mixture of phenyl compound, crystallizing enantiomer mixture and isolating solid material
    12.
    发明专利
    Preparation of optically active 3-phenylpropionic acid derivatives, used for preparing halo-phenyl compounds, comprises hydrogenating cis-isomer mixture of phenyl compound, crystallizing enantiomer mixture and isolating solid material 未知

    公开(公告)号：DE102006000839A1

    公开(公告)日：2007-07-12

    申请号：DE102006000839

    申请日：2006-01-05

    Applicant: BASF AG

    Inventor： HETTCHE FRANK ,  VOELKERT MARTIN ,  JAEKEL CHRISTOPH ,  BEY OLIVER

    IPC: C07C53/134 ,  C07B53/00 ,  C07B57/00

    Abstract: Preparation of an optically active 3-phenylpropionic acid derivative (I) comprises: (a) an enantioselective hydrogenation of a cis-isomer or cis/trans-isomer mixture of a phenyl compound (II) in the presence of a chiral hydrogenation catalyst to give an enantiomer enriched enantiomer mixture; (b) crystallization of the enantiomer enriched enantiomer mixture by supplementation of a basic salt former in a solvent and isolating the stereoisomer enriched solid material; and (c) optionally isolation of the protonated isomer or a substitutional cation. Preparation of an optically active 3-phenylpropionic acid derivative of formula (I) comprises: (a) an enantioselective hydrogenation of a cis-isomer or cis/trans-isomer mixture of a phenyl compound of formula (II) in the presence of a chiral hydrogenation catalyst to give an enantiomer enriched enantiomer mixture; (b) crystallization of the enantiomer enriched enantiomer mixture by supplementation of a basic salt former in a solvent and isolating the stereoisomer enriched solid material; and (c) optionally isolation of the protonated isomer or a substitutional cation. R 1>-R 4>H, 1-6C alkyl, halo-1-6C alkyl, OH-1-6C alkyl, 1-6C alkoxy, OH-1-6C alkoxy, 1-6C alkoxy-1-6C alkyl, OH-1-6C alkoxy-1-6C alkyl, 1-6C alkoxy-1-6C alkoxy or OH-1-6C alkoxy-1-6C alkoxy; R 5>1-6C alkyl, 5-8C cycloalkyl, phenyl or benzyl; and A : H or cationic equivalent. Independent claims are also included for: (1) the preparation of optically active halo-phenyl compound of formula (III), which comprises protonating (I) in to an acid; reducing the acids or the metal salts to give an alcohol compound of formula (IV); and halodehydroxylating (IV); and (2) an optically active compound 3-phenylpropionic acid derivative (I). Hal : Cl, Br or I. [Image] [Image].

    Separation of stereoisomeric alcohol, useful in fine chemistry and pharmaceutical chemistry, comprises distillative separation of the alcohol in the presence of chiral discriminators containing metal complex with a ligand
    13.
    发明专利
    Separation of stereoisomeric alcohol, useful in fine chemistry and pharmaceutical chemistry, comprises distillative separation of the alcohol in the presence of chiral discriminators containing metal complex with a ligand 未知

    公开(公告)号：DE102005046917A1

    公开(公告)日：2007-04-05

    申请号：DE102005046917

    申请日：2005-09-30

    Applicant: BASF AG

    Inventor： JAEKEL CHRISTOPH ,  PACIELLO ROCCO ,  KASHANI-SHIRAZI NAWID ,  KAIBEL GERD

    IPC: C07C27/32 ,  B01D3/40 ,  C07C37/80

    Abstract: Separation of stereoisomeric alcohol (A) comprises distillative separation in the presence of chiral discriminators containing metal complex with at least a ligand (I). Separation of stereoisomeric alcohol (A) comprises distillative separation in the presence of chiral discriminators containing metal complex with at least a ligand of formula (I). Either R1>-R4>alkyl (optionally substituted by 1-5 T), cycloalkyl, heterocycloalkyl or (het)aryl (all optionally substituted by 1-5 alkyl or T); or CR1>R2>, CR3>R4>5-8-membered heterocycle optionally fused to 1-3 (hetero)cycloalkyl or (het)aryl rings (optionally substituted, including on fused rings, by 1-4 (cyclo)alkyl, heterocycloalkyl, (het)aryl, OH, SH, polyalkyleneoxide, polyalkylene imine, alkoxy, halo, COOH, carboxylate, SO3, sulfonate, NE4>E5>, NE4>E5>E6>X->, NO2, alkoxycarbonyl, acyl or CN); X : completes 5-8 membered heterocycle (optionally interrupted by 1-2 optionally substituted heteroatoms) optionally fused to 1-2 (hetero)cycloalkyl or (het)aryl rings (optionally substituted, including on fused rings, by 1-4 (cyclo)alkyl, heterocycloalkyl, (het)aryl, OH, SH, polyalkylene oxide, polyalkylene imine, alkoxy, halo, COOH, carboxylate, SO3H, sulfonate, NE7>E8>, NE7>E8>E9>X->, NO3, alkoxycarbonyl, acyl or CN); or E1>-E9>H, (cyclo)alkyl or aryl; X->an anion; and T : (hetero)cycloalkyl, (het)aryl, (cyclo)alkoxy, heterocycloalkoxy, (het)aryloxy, OH, SH, polyalkylene oxide, polyalkylene imine, COOH, carboxylate, SO3H, sulfonate, NE1>E2>, NE1>E2>E3>X->, halo, NO2, acyl or CN. [Image].

    New phosphorous chelate compounds are useful as catalysts for asymmetrical synthesis (preferably as chiral components for the production of pharmaceuticals, plant protecting agents, cosmetics or flavor materials)
    15.
    发明专利
    New phosphorous chelate compounds are useful as catalysts for asymmetrical synthesis (preferably as chiral components for the production of pharmaceuticals, plant protecting agents, cosmetics or flavor materials) 未知

    公开(公告)号：DE102005061642A1

    公开(公告)日：2006-07-06

    申请号：DE102005061642

    申请日：2005-12-22

    Applicant: BASF AG

    Inventor： VOLLAND MARTIN ,  PAPP RAINER ,  HETTCHE FRANK ,  JAEKEL CHRISTOPH ,  WEISKOPF VERENA ,  PACIELLO ROCCO ,  SPRINGMANN STEFFEN

    IPC: C07F9/547 ,  B01J31/24 ,  C07C29/16 ,  C07C31/125

    Abstract: Phosphorous chelate compounds (I) are new. Phosphorous chelate compounds (I) of formula (R1>-P(R2>)-(X)a-Y1>-(O)b-P-((O)c-Rgamma )-(O)d-Rdelta ) are new. either R1>, R2>5-7 membered heterocyclic groups that are bonded over N atom to P atom; or PR1>R2>5-7 membered heterocycle additionally contains optionally substituted N atom and a further under oxygen and optionally substituted N atoms that are bonded directly to P atom; either Rgamma , Rdelta : akyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl (all substituted with 1-5 of cycloalkyl, heterocycloalkyl, aryl, hetaryl, alkoxy, cycloalkoxy, heterocycloalkoxy, aryloxy, hetaryloxy, hydroxy, thiol, polyalkylenoxide, polyalkylenimine, COOH, carboxylate, SO3H, sulfonate, NE1>E2>, NE1>E2>E3>X-, halo, NO2, acyl or CN); or PRgamma Rdelta , ORgamma Rdelta : 5-8 membered heterocycle optionally annealed with 1-3 of cycloalkyl, heterocycloalkyl, aryl or hetaryl, where the heterocycle and optionally the annealed groups are substituted with 1-4 of alkyl, cycloalkyl, heterocycloalkyl, aryl, hetaryl, hydroxy, thiol, polyalkyleneoxide, polyalkylenimine, alkoxy, halo, COOH, carboxylate, SO3H, sulfonate, NE4>E5>, NE4>E5>E6>+>X->, NO2, alkoxycarbonyl, acyl or CN; E4>, E5>, E6>H, alkyl, cycloalkyl or aryl; X : O, S, SiReRf or NRg; Re, Rf, Rg : H, alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; X->anion; Y1>bivalent carbon containing bridge atoms; and a-d : 0-1 (where at least one of b, c or d is 1). Independent claims are also included for: (1) catalyst comprising at least one complex with a transition metal, as ligands of (I); (2) preparation of chiral compounds comprising reacting prochiral compounds containing at least ethylenic unsaturated double bond, with a substrate in the presence of a chiral catalyst; (3) a method for hydroformylation of compounds containing at least ethylenic unsaturated double bond comprising reacting with carbon monoxide and hydrogen in the presence of hydroformylating catalyst; (4) preparation of 2-propylheptanol comprising subjecting butene or butene containing C4-hydrocarbon mixture of hydroformylation to obtain n-valeraldehyde containing hydroformylating products, optionally isolating hydroformylating products under n-valeraldehyde enriched groups, subjecting the obtained hydroformylating products and n-valeraldehyde enriched groups to aldol condensation, hydrogenating the products of aldol condensation, catalytically with hydrogen to alcohols and optionally subjecting the hydrogenation products to isolate 2-propylheptanol enriched groups; and (5) a method of hydroformylation of alpha -olefine and olefine with inner double bonds containing a composition, comprising reacting with carbon monoxide and hydrogen in the presence of hydroformylating catalyst in two-stage reaction system (where the first step comprises feeding an inlet containing olefin, carbon monoxide and hydrogen and converting partly catalytically; feeding and converting the discharge from the above step; and feeding the discharge from the second step with a stream obtained from non-reacted olefine and saturated hydrocarbons).

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