Separation of stereoisomeric alcohol, useful in fine chemistry and pharmaceutical chemistry, comprises distillative separation of the alcohol in the presence of chiral discriminators containing metal complex with a ligand

    公开(公告)号:DE102005046917A1

    公开(公告)日:2007-04-05

    申请号:DE102005046917

    申请日:2005-09-30

    Applicant: BASF AG

    Abstract: Separation of stereoisomeric alcohol (A) comprises distillative separation in the presence of chiral discriminators containing metal complex with at least a ligand (I). Separation of stereoisomeric alcohol (A) comprises distillative separation in the presence of chiral discriminators containing metal complex with at least a ligand of formula (I). Either R1>-R4>alkyl (optionally substituted by 1-5 T), cycloalkyl, heterocycloalkyl or (het)aryl (all optionally substituted by 1-5 alkyl or T); or CR1>R2>, CR3>R4>5-8-membered heterocycle optionally fused to 1-3 (hetero)cycloalkyl or (het)aryl rings (optionally substituted, including on fused rings, by 1-4 (cyclo)alkyl, heterocycloalkyl, (het)aryl, OH, SH, polyalkyleneoxide, polyalkylene imine, alkoxy, halo, COOH, carboxylate, SO3, sulfonate, NE4>E5>, NE4>E5>E6>X->, NO2, alkoxycarbonyl, acyl or CN); X : completes 5-8 membered heterocycle (optionally interrupted by 1-2 optionally substituted heteroatoms) optionally fused to 1-2 (hetero)cycloalkyl or (het)aryl rings (optionally substituted, including on fused rings, by 1-4 (cyclo)alkyl, heterocycloalkyl, (het)aryl, OH, SH, polyalkylene oxide, polyalkylene imine, alkoxy, halo, COOH, carboxylate, SO3H, sulfonate, NE7>E8>, NE7>E8>E9>X->, NO3, alkoxycarbonyl, acyl or CN); or E1>-E9>H, (cyclo)alkyl or aryl; X->an anion; and T : (hetero)cycloalkyl, (het)aryl, (cyclo)alkoxy, heterocycloalkoxy, (het)aryloxy, OH, SH, polyalkylene oxide, polyalkylene imine, COOH, carboxylate, SO3H, sulfonate, NE1>E2>, NE1>E2>E3>X->, halo, NO2, acyl or CN. [Image].

Patent Agency Ranking