公开(公告)号：DE50005197D1

公开(公告)日：2004-03-11

申请号：DE50005197

申请日：2000-02-22

Applicant: BASF AG

Inventor： BRUNNER MELANIE ,  HENKELMANN JOCHEM ,  KAIBEL GERD ,  KINDLER DR ,  KNOLL CHRISTIAN ,  RUST HARALD ,  TRAGUT CHRISTIAN

IPC: C07C29/17 ,  C07C29/42

公开(公告)号：DE19959053A1

公开(公告)日：2001-06-13

申请号：DE19959053

申请日：1999-12-07

Applicant: BASF AG

Inventor： KRAMER ANDREAS ,  KNOLL CHRISTIAN ,  MELDER JOHANN-PETER ,  SIEGEL WOLFGANG ,  KAIBEL GERD

IPC: C07C45/72 ,  C07B61/00 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C45/87 ,  C07C49/203

Abstract: Preparation of alpha , beta -unsaturated ketones (I) comprises reacting a ketone (II) under reflux in molar excess in the presence of a catalyst system consisting of dimethylamine or pyrrolidine and a carboxylic acid containing at least 2 C atoms, with an aldehyde (III) which is added slowly added to the reaction mixture. Preparation of alpha , beta -unsaturated ketones of formula (I) comprises reacting a ketone of formula (II) under reflux in molar excess in the presence of a catalyst system consisting of dimethylamine or pyrrolidine and a carboxylic acid containing at least 2 C atoms, with an aldehyde of formula (III) which is added slowly added to the reaction mixture. R = branched or unbranched cyclic or acyclic saturated or unsaturated aliphatic or araliphatic radical having 4-20 C atoms; and R = branched or unbranched cyclic or acyclic saturated or unsaturated aliphatic or araliphatic radical having 1-10 C atoms.

公开(公告)号：AT258907T

公开(公告)日：2004-02-15

申请号：AT00906367

申请日：2000-02-22

Applicant: BASF AG

Inventor： BRUNNER MELANIE ,  HENKELMANN JOCHEM ,  KAIBEL GERD ,  KINDLER ALOIS DR ,  KNOLL CHRISTIAN ,  RUST HARALD ,  TRAGUT CHRISTIAN

IPC: C07C29/17 ,  C07C29/42

公开(公告)号：DE10209447A1

公开(公告)日：2003-09-18

申请号：DE10209447

申请日：2002-03-05

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  RUST HARALD ,  BURKART KIRSTEN ,  KNOLL CHRISTIAN ,  HENKELMANN JOCHEM

IPC: C07D213/66 ,  B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42 ,  C07B37/12

Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha-isocyanoalkanoate ester (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha-isocyanoalkanoate ester of formula (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.

公开(公告)号：DE10209446A1

公开(公告)日：2003-09-18

申请号：DE10209446

申请日：2002-03-05

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  HENKELMANN JOCHEM ,  BECKER MICHAEL ,  RUST HARALD ,  KNOLL CHRISTIAN ,  BURKART KIRSTEN

IPC: B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42 ,  C07B37/12

Abstract: Production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha-isocyanoalkanoate ester (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and simultaneously separating the product from the reaction mixture. Production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha-isocyanoalkanoate ester of formula (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and simultaneously separating the product from the reaction mixture. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II), converting (II) to (I) as above; (4) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (5) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.

公开(公告)号：AU2003223951A1

公开(公告)日：2003-09-16

申请号：AU2003223951

申请日：2003-02-28

Applicant: BASF AG

Inventor： BURKART KIRSTEN ,  KINDLER ALOIS ,  HENKELMANN JOCHEM ,  BECKER MICHAEL ,  RUST HARALD ,  KNOLL CHRISTIAN

IPC: C07D263/42

公开(公告)号：DE10137480A1

公开(公告)日：2003-02-13

申请号：DE10137480

申请日：2001-08-03

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN

IPC: C07D233/70 ,  C07D213/67 ,  C07D263/42 ,  C07D213/66

Abstract: Production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 deg C in the presence of an auxiliary agent and simultaneously separating the product from the reaction mixture. Production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 deg C in the presence of an auxiliary agent and simultaneously separating the product from the reaction mixture. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II), converting (II) to (I) as above; (4) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (5) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.

公开(公告)号：AT384706T

公开(公告)日：2008-02-15

申请号：AT02016707

申请日：2002-07-26

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D263/42

Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.

公开(公告)号：DE10209458A1

公开(公告)日：2003-09-18

申请号：DE10209458

申请日：2002-03-05

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  HENKELMANN JOCHEM ,  BECKER MICHAEL ,  RUST HARALD ,  KNOLL CHRISTIAN ,  BURKART KIRSTEN

IPC: C07D263/42 ,  C07B37/12 ,  C07D213/67

公开(公告)号：DE10137627A1

公开(公告)日：2003-02-20

申请号：DE10137627

申请日：2001-08-03

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D213/67 ,  C07D263/42 ,  C07D213/66

Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 deg C in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 deg C in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.