公开(公告)号：JP2003261546A

公开(公告)日：2003-09-19

申请号：JP2002355604

申请日：2002-12-06

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D213/66 ,  B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a new process for the continuous preparation of a 5- alkoxy-substituted oxazole in high yield and high space-time yield. SOLUTION: The process for the continuous preparation of a 5-alkoxy- substituted oxazole of formula I (R 1 is a substituted or unsubstituted 1-6C alkyl; and R 2 is H or a substituted or unsubstituted 1-6C alkyl) comprises the conversion of a continuously charged α-isocyanoalkanoic acid ester of formula II to the 5-alkoxy-substituted oxazole of formula I in a reactor at ≥80°C in the presence of an assistant selected from continuously charged alcohols and esters and the continuous discharge of the reaction product from the reactor. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2003026620A

公开(公告)日：2003-01-29

申请号：JP2002130876

申请日：2002-05-02

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： ANSMANN ANDREAS ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  ETZRODT HEINZ ,  OOST CARSTEN ,  STUTZ SUSANNE ,  TRAGUT CHRISTIAN ,  BOCKSTIEGEL BERNHARD ,  REIMER KLAUS ,  STROEZEL MANFRED ,  DOBLER WALTER

IPC: B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/02 ,  C07B61/00 ,  C07C29/17 ,  C07C29/32 ,  C07C29/42 ,  C07C33/02 ,  C07C33/048 ,  C07C45/48 ,  C07C45/62 ,  C07C45/67 ,  C07C49/203

CPC classification number: C07C49/203 ,  B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0225 ,  C07C29/17 ,  C07C29/42 ,  C07C45/62 ,  C07C45/676 ,  C07C33/02 ,  C07C33/048 ,  C07C49/04

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a higher α,β-unsaturated alcohol in which engineering is easily performed. SOLUTION: This method for producing the alcohol represented by formula Ia or Ib [R is a 1-4C alkyl group; R is a group of formula II (R is hydrogen or a 1-4C alkyl group; a broken line is an additional double bond; and n is 0 or 1-6), hydrogen, or a saturated alkyl group] comprises (a) mono-ethynylating a ketone or formula: R -CO-CH2 -R in ammonia solution by using a basic catalyst, (b) optionally hydrogenating the alcohol of formula Ib on a Pd catalyst, and (c) subjecting the hydrogenated product to a purification distillation, and if necessary, reacting Ia or Ib produced by the steps (a) to (c) or by the steps (a) and (c) with an alkyl acetoacetate of formula IV [R is a 1-4C alkyl group], or a diketene to provide a methyl ketone, and using the ketone as a starting material in the steps (a) to (c).

Abstract translation: 要解决的问题：提供一种制造其中易于进行工程的较高α，β-不饱和醇的方法。 解决方案：用于制备由式Ia或Ib表示的醇的方法[R 1]是1-4C烷基; R 2是式II的基团（R 3是氢或1-4C烷基;虚线是另外的双键; n是0或1-6），氢或饱和烷基 基团]包括（a）通过使用碱性催化剂在氨溶液中使酮或式：R 1 -CO-CH 2 -R 2单乙炔基化，（b）任选地在Pd催化剂上氢化式Ib的醇 和（c）使氢化产物进行纯化蒸馏，如果需要，使由步骤（a）至（c）或步骤（a）和（c）制备的Ia或Ib与式 IV [R 5是1-4C烷基]或二烯酮以提供甲基酮，并且在步骤（a） - （c）中使用酮作为原料。

公开(公告)号：JP2003176272A

公开(公告)日：2003-06-24

申请号：JP2002227292

申请日：2002-08-05

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  BECKER MICHAEL

IPC: C07D233/70 ,  C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a 5-alkoxy-substituted oxazole and a method for producing a pyridoxine derivative. SOLUTION: The 5-alkoxy-substituted oxazole is obtained by converting an α-isocyano alkylic acid ester in the presence of a base at >80°C and separating the 5-alkoxy-substituted oxazole from the reaction mixture simultaneously with the converting reaction, and the pyridoxine derivative is obtained by converting an amino acid into an amino acid ester, converting the obtained into a formamido acid ester, converting the obtained into an α-isocyanoalkyl acid ester, converting the obtained into a 5-alkoxy-substituted oxazole in the presence of a base at >80°C and separating the 5-alkoxy-substituted oxazole from the reaction mixture simultaneously with the converting reaction, reacting the obtained 5-alkoxy-substituted oxazole with a protective diol to obtain an Diels-Alder adduct and treating the obtained with an acid and removing the protective group to convert into the pyridoxine derivative. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2001002607A

公开(公告)日：2001-01-09

申请号：JP2000155227

申请日：2000-05-25

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  PREISS THOMAS DR ,  HENKELMANN JOCHEM DR

IPC: B01J31/02 ,  C07B61/00 ,  C07C29/42 ,  C07C33/044 ,  C07C33/046

Abstract: PROBLEM TO BE SOLVED: To obtain the subject alkyne diol by allowing a specific compound to react with acetylene in the presence of a basic alkali metal salt as a catalyst in a polar aprotic solvent in need of a trace or catalytic amount of base. SOLUTION: (A) A compound of the formula: R1-C(=O)-R2 [R1 and R2 are each H, a 1-20C hydrocarbon (which may bear a C-C double or triple bond that is interrupted with a substituted and nonadjacent hetero atom)] and (B) acetylene are allowed to react with each other in the presence of (C) a catalyst of a basic alkali metal salt in an amount of 5-65 mol.% based on the component B in (D) a polar aprotic solvent (for example, tetrahydrofuran) under a pressure of 0.1-10 bar at -20-60 deg.C to give an objective compound represented by the formula: R1R2C(OH)-C≡C-C(OH)R1R2. As the component C, is preferably cited an alkali metal alkoxide (for example, potassium alkoxide).

公开(公告)号：JP2004034019A

公开(公告)日：2004-02-05

申请号：JP2002367784

申请日：2002-12-19

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： KAIBEL GERD DR ,  MILLER CHRISTIAN ,  KLAS KATRIN ,  KINDLER ALOIS ,  AQUILA WERNER ,  DOBLER WALTER ,  BREUER KLAUS ,  POMMER ACHIM ,  DIRNSTEINER THOMAS

IPC: B01D3/26 ,  B01D3/14

CPC classification number: B01D3/141 ,  B01D3/14 ,  Y10S203/11 ,  Y10S203/20

Abstract: PROBLEM TO BE SOLVED: To provide a distillation column having high separation efficiency, in which the vapor amount is made constant all over the column including a feed section and a side steam take-off section.
SOLUTION: Partition walls DW are arranged substantially along the longitudinal direction of the distillation column so that the inside of the distillation column is divided into an upper zone 2 and a lower zone 4 of the feed section, an upper zone 3 and a lower zone 5 of the side stream take-off section, an upper common column section 1 and a lower common column section 6. A feeding mixture to be separated between the zones 2 and 4 of the feed section is in a wholly or partially vaporized state and/or the side stream to be taken off from the zones 3 and 5 of the side stream take-off section is in a wholly or partially vaporized state.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2003267958A

公开(公告)日：2003-09-25

申请号：JP2002355822

申请日：2002-12-06

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  BECKER MICHAEL

IPC: B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a 5-alkoxy-substituted oxazole, especially a 4-methyl-5-alkoxy-substituted oxazole and further a method for producing a pyridoxine derivative. SOLUTION: The method for producing the substituted oxazole is carried out as follows. An α-isocyanoalkanoic acid ester is converted into the 5-alkoxy- substituted oxazole in the presence of an assistant composed of an alcohol or an ester at >80°C. The resultant 5-alkoxy-substituted oxazole is taken out of the reactional mixture simultaneously with the conversion. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2003201283A

公开(公告)日：2003-07-18

申请号：JP2002227742

申请日：2002-08-05

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for continuously producing a 5-alkoxy-substituted oxazole and a method for producing a pyridoxine derivative by using the same. SOLUTION: This method for obtaining a pyridoxine derivative is provided by converting an α-isocyanoalkanoic acid ester expressed by the formula II in the presence of continuously supplied base at ≥80°C temperature to a 5- alkoxy-substituted oxazole I, taking it out from a reactor at the same time with the reaction, performing a reaction of the compound I with a compound VI to make a compound VII, and acid-treating it to obtain a pyridoxine derivative IX (in formulae, R 1 is an alkyl, R 2 is H or an alkyl, R 3 , R 4 are each independently a protection group of hydroxy group). COPYRIGHT: (C)2003,JPO

公开(公告)号：DE10359026A1

公开(公告)日：2005-07-21

申请号：DE10359026

申请日：2003-12-15

Applicant: BASF AG

Inventor： DOBLER WALTER ,  BAHR NICOLAUS ,  KINDLER ALOIS ,  MILLER CHRISTIAN ,  SALDEN AXEL

IPC: C07C45/62 ,  C07C45/74 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/38 ,  C07D231/56 ,  C07D233/54 ,  C07D235/06 ,  C07D249/12 ,  C07D257/04 ,  C07D311/72 ,  C07D401/12 ,  C07D403/12 ,  C07D409/04 ,  C07D473/34 ,  C07C45/72 ,  C07C49/04 ,  C07C29/145 ,  C07C33/025 ,  C07C33/03

Abstract: The present invention relates to a process for preparing tetrahydrogeranylacetone (tetrahydropseudoionone) by aldol condensation of citral with acetone and subsequent hydrogenation. The invention further relates to the use of thus obtained tetrahydro-geranylacetone for preparing phytol, isophytol, tocopherol and/or tocopherol derivatives. In addition, the invention relates to processes for preparing tocopherols and/or tocopherol derivatives.

公开(公告)号：AU2003290118A1

公开(公告)日：2004-07-22

申请号：AU2003290118

申请日：2003-12-23

Applicant: HENKELMANN JOCHEM ,  BASF AG ,  KINDLER ALOIS ,  BURKHART KIRSTEN

Inventor： KNOLL CHRISTIAN ,  KINDLER ALOIS ,  BURKHART KIRSTEN ,  HENKELMANN JOCHEM

IPC: C07D213/67 ,  C07D498/08 ,  C07D498/18

公开(公告)号：DE10236578A1

公开(公告)日：2004-02-19

申请号：DE10236578

申请日：2002-08-08

Applicant: BASF AG

Inventor： HENKELMANN JOCHEM ,  KINDLER ALOIS ,  ARNDT JAN-DIRK ,  KLAS KATRIN

IPC: C07B61/00 ,  C07C29/42 ,  C07C33/042 ,  C07C33/048 ,  C07C33/14 ,  C07C33/48 ,  C07C403/00

Abstract: A method for the production of acetylene alcohols by mono-ethynylation of ketones comprising: (a) reaction of lithium with a 1-10C alkyl halide; (b) introduction of acetylene gas; and (c) addition of the ketone. A method for the production of acetylene alcohols of formula (I) by mono-ethynylation of ketones of formula R1-CO-R2 comprising: (a) reaction of lithium with a 1-10C alkyl halide, (b) introduction of acetylene gas and (c) addition of the ketone. HCequivalent toC-CR1R2-OH (I) R1, R2 = H or optionally unsaturated 1-30C alkyl, aryl, cycloalkylalkyl or cycloalkyl (all optionally substituted), or groups of formula -CH2CH2CHR3R4 or -CH2CH=CR3R4; and R3, R4 = H or optionally unsaturated, optionally substituted 1-30C alkyl, aryl, cycloalkylalkyl or cycloalkyl.