公开(公告)号：PL373006A1

公开(公告)日：2005-08-08

申请号：PL37300602

申请日：2002-01-19

Applicant: BASF AG

Inventor： HERMANN THERON ,  PATTERSON THOMAS A ,  PERO JANICE G ,  YOCUM ROGER R ,  BALDENIUS KAI-UWE ,  BECK CHRISTINE

IPC: A61K31/7088 ,  A61P43/00 ,  C12N1/21 ,  C12N9/10 ,  C12N15/09 ,  C12P13/00 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12N15/03 ,  C07H21/04

Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：SK9022003A3

公开(公告)日：2003-12-02

申请号：SK9022003

申请日：2002-01-19

Applicant: BASF AG

Inventor： HERMANN THERON ,  PATTERSON THOMAS A ,  PERO JANICE G ,  YOCUM ROGERS R ,  BALDENIUS KAI-UWE ,  BECK CHRISTINE

IPC: A61K31/7088 ,  A61P43/00 ,  C12N1/21 ,  C12N9/10 ,  C12P13/00 ,  C12P13/02 ,  C12N15/09 ,  C12P13/04 ,  C12R1/125 ,  C12P7/42 ,  C12P13/06

Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：CZ20031886A3

公开(公告)日：2003-10-15

申请号：CZ20031886

申请日：2002-01-18

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12N15/03 ,  C07C235/12

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：CA2434626A1

公开(公告)日：2002-08-08

申请号：CA2434626

申请日：2002-01-18

Applicant: BASF AG

Inventor： HERMANN THERON ,  PERO JANICE G ,  PATTERSON THOMAS A ,  YOCUM R ROGERS

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12N15/03 ,  C07C235/12

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particula r, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produce d by such microorganisms.

公开(公告)号：HU227432B1

公开(公告)日：2011-06-28

申请号：HU0501185

申请日：2002-01-18

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N9/04 ,  C12N1/21 ,  C12N15/09 ,  C12N9/00 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

公开(公告)号：CA2615416A1

公开(公告)日：2007-01-25

申请号：CA2615416

申请日：2006-07-18

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  YOCUM ROGERS R ,  HAEFNER STEFAN ,  HERMANN THERON ,  ZELDER OSKAR ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HEROLD ANDREA ,  WILLIAMS MARK K ,  KLOPPROGGE CORINNA

IPC: C12P13/12

Abstract: This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.

公开(公告)号：PL356566A1

公开(公告)日：2004-06-28

申请号：PL35656600

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00 ,  C12N15/54 ,  C12P7/42

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

公开(公告)号：CA2491137A1

公开(公告)日：2004-01-15

申请号：CA2491137

申请日：2002-07-03

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C07H21/04 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/10 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particula r, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：NO20033240L

公开(公告)日：2003-09-17

申请号：NO20033240

申请日：2003-07-17

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N15/09 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12P13/025 ,  C12N1/20

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：NO20033240D0

公开(公告)日：2003-07-17

申请号：NO20033240

申请日：2003-07-17

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N1/21 ,  C12N15/09 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12P

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.