公开(公告)号：EP2888351A4

公开(公告)日：2016-04-27

申请号：EP13831449

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N15/52 ,  C12N9/00 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12P17/18

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：WO2010081885A3

公开(公告)日：2011-01-13

申请号：PCT/EP2010050475

申请日：2010-01-15

Applicant: BASF SE ,  ZELDER OSKAR ,  BUCKEL WOLFGANG ,  DJURDJEVIC IVANA

Inventor： ZELDER OSKAR ,  BUCKEL WOLFGANG ,  DJURDJEVIC IVANA

IPC: C12P7/44 ,  C12P7/50

CPC classification number: C12P7/44 ,  C12N9/0006 ,  C12N9/13 ,  C12N9/88 ,  C12P7/50

Abstract: The present invention relates to a novel method for the biocatalytic production of unsaturated dicarboxylic acids by cultivating a recombinant microorganism co-expressing a glutaconate CoA-transferase and a 2-hydroxyglutaryl-CoA dehydratase system. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyamide or polyester copolymers making use of said dicarboxylic acids as obtained by said biocatalytic production method.

Abstract translation: 本发明涉及通过培养共表达戊二酸CoA转移酶和2-羟基戊二酰辅酶A脱水酶系统的重组微生物来生物催化生产不饱和二羧酸的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及通过所述生物催化生产方法获得的制备使用所述二羧酸的聚酰胺或聚酯共聚物的方法。

公开(公告)号：WO2014030096A3

公开(公告)日：2014-04-17

申请号：PCT/IB2013056604

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA ,  BASF CHINA CO LTD

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N1/21 ,  A61K31/48 ,  C07K14/195 ,  C07K14/37 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N15/31 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12P1/00 ,  C12P17/10

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：EP3039121A4

公开(公告)日：2017-05-03

申请号：EP14839975

申请日：2014-08-18

Applicant: BASF SE

Inventor： KRAWCZYK JOANNA MARTYNA ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  ZELDER OSKAR ,  FABARIUS JONATHAN THOMAS

IPC: C12N9/06

CPC classification number: C12P13/06 ,  C12N9/0016 ,  C12R1/01 ,  C12Y104/01001

公开(公告)号：EP2922954A4

公开(公告)日：2016-06-15

申请号：EP13857215

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRÖDER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RÜDIGER ,  WEBER JAKOB

IPC: C07K14/37 ,  C12R1/645

CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：WO2009092793A2

公开(公告)日：2009-07-30

申请号：PCT/EP2009050778

申请日：2009-01-23

Applicant: BASF SE ,  VOELKERT MARTIN ,  ZELDER OSKAR ,  ERNST BURKHARD ,  JEONG WEOL KYU

Inventor： VOELKERT MARTIN ,  ZELDER OSKAR ,  ERNST BURKHARD ,  JEONG WEOL KYU

IPC: C12P13/00

CPC classification number: C12P13/001 ,  C07C209/84 ,  C07C211/09

Abstract: The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermative production of DAP using said isolating method and to a method for producing DAP-containing polymers using the isolated or fermatively produced DAPs according to said methods.

Abstract translation: 本发明涉及一种用于从含DAP-发酵液中分离1,5-二氨基戊烷（DAP），一种用于发酵生产DAP的使用所述分离方法，以及以这种方式制造使用该含DAP-聚合物的方法 分离或通过发酵的DAP制备。

公开(公告)号：ES2870324T3

公开(公告)日：2021-10-26

申请号：ES18727743

申请日：2018-05-18

Applicant: BASF SE

Inventor： SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  ZELDER OSKAR ,  WITTMANN CHRISTOPH ,  SCHROER ANNA CHRISTINE ,  HOFF BIRGIT ,  BOEHMER NICO

IPC: C12N9/12 ,  C12P7/46 ,  C12R1/01

Abstract: Un procedimiento de producción de un compuesto orgánico, comprendiendo el procedimiento I) cultivar un microorganismo modificado genéticamente en un medio de cultivo que comprende la sacarosa como una fuente de carbono asimilable para permitir que el microorganismo modificado genéticamente produzca el compuesto orgánico, II) recuperar el compuesto orgánico del caldo de fermentación obtenido en la etapa I del procedimiento), en el que el microorganismo modificado genéticamente comprende A) al menos una modificación genética que conduce a una mayor actividad de la enzima codificada por el gen rbsK, en comparación con el microorganismo original que no ha sido modificado genéticamente, en el que al menos una modificación genética A) comprende una sobreexpresión del gen rbsK, en el que el microorganismo original pertenece a la familia Pasteurellaceae y en el que el compuesto orgánico es ácido succínico.

公开(公告)号：CA3062384A1

公开(公告)日：2018-11-22

申请号：CA3062384

申请日：2018-05-18

Applicant: BASF SE

Inventor： SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  ZELDER OSKAR ,  WITTMANN CHRISTOPH ,  SCHROER ANNA CHRISTINE ,  HOFF BIRGIT ,  BOEHMER NICO

IPC: C12N9/12 ,  C12P7/46

Abstract: The present invention relates to a process of producing an organic compound, the process comprising I) cultivating a genetically modified microorganism in a culture medium comprising sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and wherein the original microorganism belongs to the family Pasteurellaceae. The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

公开(公告)号：CY1114595T1

公开(公告)日：2016-10-05

申请号：CY131100999

申请日：2013-11-11

Applicant: BASF SE

Inventor： KRÖGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRÖDER HARTWIG ,  HAEFNER STEFAN

IPC: C12N15/77 ,  C07K14/34 ,  C12P13/08

Abstract: Ηπαρούσαεφεύρεσηαφοράστηχρησιμοποίησηακολουθιώννουκλεϊνικούοξέοςγιατηρύθμισητηςμεταγραφήςκαιέκφρασηςγονιδίων, στουςνέουςίδιουςπροαγωγούςκαιενότητεςέκφρασης, σεμεθόδουςγιατηντροποποίησηή πρόκλησητουρυθμούμεταγραφήςκαι/ήτουρυθμούέκφρασηςγονιδίων, σεκασέτεςέκφρασηςπουπεριέχουντιςενότητεςέκφρασης, στουςγενετικάτροποποιημένουςμικροοργανισμούςμετροποποιημένοή προκληθένταρυθμόμεταγραφήςκαι/ήρυθμόέκφρασης, καθώςκαισεμεθόδουςγιατηνπαρασκευήβιοσυνθετικώνπροϊόντωνμεκαλλιέργειατωνγενετικάτροποποιημένωνμικροοργανισμών.

公开(公告)号：HUE025440T2

公开(公告)日：2016-04-28

申请号：HUE07821516

申请日：2007-10-18

Applicant: BASF SE

Inventor： HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  JEONG WEOL KYU

IPC: C12N15/77