公开(公告)号：JP2014012713A

公开(公告)日：2014-01-23

申请号：JP2013184614

申请日：2013-09-06

Applicant: Basf Se ,  ビーエーエスエフ ソシエタス・ヨーロピアBasf Se

Inventor： DITRICH KLAUS ,  FRANK HAESE

IPC: C07D265/30 ,  C07B57/00

CPC classification number: C07D295/027

Abstract: PROBLEM TO BE SOLVED: To provide a method of producing optically active trans-2,6-dimethylmorpholine.SOLUTION: A method of producing optically active trans-2,6-dimethylmorpholine comprises steps of: (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid; (ii) separating a salt, formed from D-mandelic acid and one enantiomer of the trans-2,6-dimethylmorpholine, from the other enantiomer of the trans-2,6-dimethylmorpholine by precipitation and taking out the salt; and (iii) isolating desired optically active trans-2,6-dimethylmorpholine.

Abstract translation: 要解决的问题：提供光学活性的反式-2,6-二甲基吗啉的制备方法。溶液：光学活性的反式-2,6-二甲基吗啉的制备方法包括以下步骤：（ⅰ）使外消旋的反式-2,6 二甲基吗啉与D-扁桃酸; （ii）通过沉淀和取出盐从反式-2,6-二甲基吗啉的另一个对映异构体中分离由D-扁桃酸和反式-2,6-二甲基吗啉的一个对映异构体形成的盐; 和（iii）分离所需的光学活性反式-2,6-二甲基吗啉。

公开(公告)号：WO2014030096A3

公开(公告)日：2014-04-17

申请号：PCT/IB2013056604

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA ,  BASF CHINA CO LTD

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N1/21 ,  A61K31/48 ,  C07K14/195 ,  C07K14/37 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N15/31 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12P1/00 ,  C12P17/10

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：WO2014041011A3

公开(公告)日：2014-05-08

申请号：PCT/EP2013068786

申请日：2013-09-11

Applicant: BASF SE ,  BASF SCHWEIZ AG ,  UNIV GRONINGEN

Inventor： BALDENIUS KAI-UWE ,  DITRICH KLAUS ,  BREUER MICHAEL ,  NAVICKAS VAIDOTAS ,  DICK JANSEN ,  BARTSCH SEBASTIAN ,  CRISMARU CIPRIAN GICA

IPC: C12P13/00 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10

CPC classification number: C12N9/1096 ,  C12N9/0006 ,  C12P13/001 ,  C12Y101/01001 ,  C12Y104/01001 ,  C12Y206/01018

Abstract: The present invention relates to a novel enzymatically catalyzed method for the production of aliphatic primary amines, which method comprises the enzymatic oxidation of a primary aliphatic alcohol catalyzed by an alcohol dehydrogenase, amination of the resulting oxocompound catalyzed by a transaminase and optionally coupled with an enzymatically catalyzed regeneration of the consumed cofactor; recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods; as well as the use of the obtained amines in organic synthesis, in particular for preparing organic polymers.

Abstract translation: 本发明涉及用于生产脂族伯胺的新的酶催化方法，该方法包括由醇脱氢酶催化的伯脂肪醇的酶氧化，由转氨酶催化的所得氧化合物的胺化，并任选地与酶 消耗的辅因子的催化再生; 重组表达系统和微生物获得所需的酶活性; 和用于进行这种方法的生物反应器; 以及在有机合成中使用得到的胺，特别是制备有机聚合物。

公开(公告)号：WO2011012632A3

公开(公告)日：2011-05-26

申请号：PCT/EP2010060917

申请日：2010-07-27

Applicant: BASF SE ,  HAUER BERNHARD ,  SCHNEIDER NINA ,  DREW DEJANA ,  DITRICH KLAUS ,  TURNER NICK ,  NESTL BETTINA M

Inventor： HAUER BERNHARD ,  SCHNEIDER NINA ,  DREW DEJANA ,  DITRICH KLAUS ,  TURNER NICK ,  NESTL BETTINA M

IPC: C12P13/00

CPC classification number: C12P13/001 ,  C07C211/27

Abstract: The present invention relates to a method for the enzymatic hydroamination of C-C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of Petroselinum crispum, Rhodoturula glutinis and/or functional active derivatives thereof.

Abstract translation: 本发明涉及一种通过酶结构和/或功能性相关的苯丙氨酸氨裂解酶（PAL）分离的酶的催化C-C双键的方法，所述苯丙氨酸氨裂解酶（PAL）从石斛兰，红酵母和/或其功能活性衍生物的微生物分离。

公开(公告)号：EP2643281A4

公开(公告)日：2014-06-04

申请号：EP11843794

申请日：2011-11-21

Applicant: BASF SE

Inventor： BONNEKESSEL MELANIE ,  DITRICH KLAUS ,  DÄUWEL JÜRGEN ,  SORG ACHIM ,  LADNER WOLFGANG ,  COOPER BRYAN ,  BACKES RENE

IPC: C12P41/00 ,  C07C35/08 ,  C12N11/14 ,  C12P7/02

CPC classification number: C12N11/14 ,  C12P7/02 ,  C12P41/004 ,  C12Y301/01003

公开(公告)号：EP2888351A4

公开(公告)日：2016-04-27

申请号：EP13831449

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N15/52 ,  C12N9/00 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12P17/18

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：EP2922954A4

公开(公告)日：2016-06-15

申请号：EP13857215

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRÖDER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RÜDIGER ,  WEBER JAKOB

IPC: C07K14/37 ,  C12R1/645

CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：HUE051855T2

公开(公告)日：2021-03-29

申请号：HUE15763307

申请日：2015-09-11

Applicant: BASF SE

Inventor： PUHL MICHAEL ,  DITRICH KLAUS ,  KELLER ANDREAS ,  DIMITROVA PEPA ,  WEINGARTEN MELANIE ,  SIEGEL WOLFGANG

IPC: C07H3/06 ,  C07H15/26

公开(公告)号：AU2013349330B2

公开(公告)日：2019-08-01

申请号：AU2013349330

申请日：2013-11-13

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  HOFF BIRGIT ,  SCHRODER HARTWIG ,  MOLT ANDREA ,  HARTMANN HOLGER ,  DITRICH KLAUS ,  BREUER MICHAEL ,  REINGRUBER RUDIGER ,  WEBER JAKOB

IPC: C12N15/11 ,  A01N37/00 ,  C07D307/77 ,  C12N15/63 ,  C12N15/67

Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：AU2015314165B2

公开(公告)日：2019-06-06

申请号：AU2015314165

申请日：2015-09-11

Applicant: BASF SE

Inventor： PUHL MICHAEL ,  DITRICH KLAUS ,  KELLER ANDREAS ,  DIMITROVA PEPA ,  WEINGARTEN MELANIE ,  SIEGEL WOLFGANG

IPC: C07H3/06 ,  A23L33/10 ,  C07H15/26

Abstract: The present invention relates to a method for preparing 2'-O-fucosyllactose, the 2'-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C