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    GENE CLUSTER FOR BIOSYNTHESIS OF CYCLOCLAVINE
    2.
    发明申请
    GENE CLUSTER FOR BIOSYNTHESIS OF CYCLOCLAVINE 审中-公开
    CYCLOCLAVINE生物化学基因组

    公开(公告)号：WO2012116935A3

    公开(公告)日：2012-10-26

    申请号：PCT/EP2012053197

    申请日：2012-02-24

    Applicant: BASF SE ,  SCHROEDER HARTWIG ,  HOFF BIRGIT

    Inventor： SCHROEDER HARTWIG ,  HOFF BIRGIT

    IPC: A61K31/48

    CPC classification number: C12P17/182 ,  A61K31/48 ,  C12N15/52 ,  C12P17/10

    Abstract: The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention.

    Abstract translation: 本发明原则上涉及生物碱重组生产领域，特别是环己烯环素。 它提供参与环烯克蛋白生物合成的酶的基因簇的多核苷酸以及包含这种多核苷酸的载体和宿主细胞。 还提供了由所述多核苷酸编码的多肽，其可以用于制备本发明也包括的环己烯环的方法。

    Procedimiento de producción de un compuesto orgánico
    3.
    发明专利
    Procedimiento de producción de un compuesto orgánico 未知

    公开(公告)号：ES2870324T3

    公开(公告)日：2021-10-26

    申请号：ES18727743

    申请日：2018-05-18

    Applicant: BASF SE

    Inventor： SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  ZELDER OSKAR ,  WITTMANN CHRISTOPH ,  SCHROER ANNA CHRISTINE ,  HOFF BIRGIT ,  BOEHMER NICO

    IPC: C12N9/12 ,  C12P7/46 ,  C12R1/01

    Abstract: Un procedimiento de producción de un compuesto orgánico, comprendiendo el procedimiento I) cultivar un microorganismo modificado genéticamente en un medio de cultivo que comprende la sacarosa como una fuente de carbono asimilable para permitir que el microorganismo modificado genéticamente produzca el compuesto orgánico, II) recuperar el compuesto orgánico del caldo de fermentación obtenido en la etapa I del procedimiento), en el que el microorganismo modificado genéticamente comprende A) al menos una modificación genética que conduce a una mayor actividad de la enzima codificada por el gen rbsK, en comparación con el microorganismo original que no ha sido modificado genéticamente, en el que al menos una modificación genética A) comprende una sobreexpresión del gen rbsK, en el que el microorganismo original pertenece a la familia Pasteurellaceae y en el que el compuesto orgánico es ácido succínico.

    PROCESS FOR PRODUCING AN ORGANIC COMPOUND
    4.
    发明专利
    PROCESS FOR PRODUCING AN ORGANIC COMPOUND 未知

    公开(公告)号：CA3062384A1

    公开(公告)日：2018-11-22

    申请号：CA3062384

    申请日：2018-05-18

    Applicant: BASF SE

    Inventor： SCHROEDER HARTWIG ,  HAEFNER STEFAN ,  ZELDER OSKAR ,  WITTMANN CHRISTOPH ,  SCHROER ANNA CHRISTINE ,  HOFF BIRGIT ,  BOEHMER NICO

    IPC: C12N9/12 ,  C12P7/46

    Abstract: The present invention relates to a process of producing an organic compound, the process comprising I) cultivating a genetically modified microorganism in a culture medium comprising sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and wherein the original microorganism belongs to the family Pasteurellaceae. The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

    Gene cluster for biosynthesis of cycloclavine
    8.
    发明专利
    Gene cluster for biosynthesis of cycloclavine 未知

    公开(公告)号：AU2012222492A1

    公开(公告)日：2013-08-29

    申请号：AU2012222492

    申请日：2012-02-24

    Applicant: BASF SE

    Inventor： SCHRODER HARTWIG ,  HOFF BIRGIT

    IPC: A61K31/48

    Abstract: The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention.

    METHOD OF REMOVING DNA FROM BIOTECHNOLOGICAL PRODUCTS
    10.
    发明专利
    METHOD OF REMOVING DNA FROM BIOTECHNOLOGICAL PRODUCTS 未知

    公开(公告)号：CA2969046A1

    公开(公告)日：2016-06-16

    申请号：CA2969046

    申请日：2015-12-09

    Applicant: BASF SE

    Inventor： HOFF BIRGIT ,  HAEFNER STEFAN ,  JEONG WEOL KYU ,  SCHOLTEN EDZARD

    IPC: C12N1/08 ,  C12N1/06 ,  C12P25/00

    Abstract: The present invention relates to a method for degrading DNA in a sample obtained by microbial fermentation or biotransformation, comprising treating the sample with a combination of increased temperature and low pH. It also relates to a method for releasing DNA from a microbial cell, comprising incubating the microbial cell at a temperature of 45°C to 55°C for two to ten hours. Finally, the present invention provides a method for producing a product, comprising a step of releasing DNA from a microbial cell and degrading said DNA.

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