公开(公告)号：BR0212833A

公开(公告)日：2004-10-13

申请号：BR0212833

申请日：2002-09-25

Applicant: BAXTER INT

Inventor： BRYNJELSEN SEAN ,  STERNBERG SHMUEL ,  DUNHAM ANDREW J ,  DOTY MARK J ,  KIPP JAMES E ,  JAYSWAL NAILESH ,  NARAYANAN KRISHNASWAMY

IPC: A61K9/14 ,  A61K9/19 ,  A61K9/51 ,  A61K31/496 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

公开(公告)号：ZA200304742B

公开(公告)日：2004-08-24

申请号：ZA200304742

申请日：2003-06-19

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE ,  SPIRAM RAJARAM

IPC: A61K20060101 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K

Abstract: The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.

公开(公告)号：CA2463313A1

公开(公告)日：2003-05-01

申请号：CA2463313

申请日：2002-10-18

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  KONKEL JAMIE TERESA ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  KIPP JAMES E

IPC: A61K8/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/60 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61K8/89 ,  A61K8/891 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K31/12 ,  A61K31/4985 ,  A61K31/58 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/46 ,  A61Q19/00

Abstract: The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particl es of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

公开(公告)号：CA2461349C

公开(公告)日：2011-11-29

申请号：CA2461349

申请日：2002-09-25

Applicant: BAXTER INT

Inventor： BRYNJELSEN SEAN ,  STERNBERG SHMUEL ,  DUNHAM ANDREW J ,  DOTY MARK J ,  KIPP JAMES E ,  JAYSWAL NAILESH ,  NARAYANAN KRISHNASWAMY

IPC: A61K9/14 ,  A61K9/51 ,  A61K9/19 ,  A61K31/496 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

公开(公告)号：ES2340261T3

公开(公告)日：2010-06-01

申请号：ES02773797

申请日：2002-10-18

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  KONKEL JAMIE TERESA

IPC: A61K9/10 ,  A61K8/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/60 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61K8/89 ,  A61K8/891 ,  A61K9/107 ,  A61K9/14 ,  A61K31/12 ,  A61K31/4985 ,  A61K31/58 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/46 ,  A61Q19/00

Abstract: Composición de una suspensión de un agente farmacéutico orgánico poco soluble en agua que comprende partículas del compuesto y un excipiente en una cantidad del 0,001% al 20% con respecto al peso total de la composición suspendida en una matriz acuosa congelada, caracterizada porque el excipiente incluye dos o más modificadores superficiales seleccionados de entre agentes tensioactivos aniónicos, agentes tensioactivos catiónicos, agentes tensioactivos no iónicos y modificadores biológicos activos superficiales, donde los modificadores biológicos activos superficiales se seleccionan de entre el grupo consistente en albúmina, caseína, heparina, hirudina u otras proteínas, y caracterizada porque más del 99% aproximadamente de las partículas tiene un tamaño de partícula inferior a 5 micras.

公开(公告)号：ZA200506900B

公开(公告)日：2006-08-30

申请号：ZA200506900

申请日：2005-08-29

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH C T ,  WELING JANE R C L ,  BRYNJELSEN SEAN

IPC: A61K20060101 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：NO20054732A

公开(公告)日：2005-10-14

申请号：NO20054732

申请日：2005-10-14

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

CPC classification number: A61K31/495 ,  A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1682 ,  A61K9/1688 ,  A61K31/12 ,  A61K31/337 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

公开(公告)号：NO20032860L

公开(公告)日：2003-08-21

申请号：NO20032860

申请日：2003-06-20

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE ,  SRIRAM RAJARAM

IPC: C07D407/14 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10

公开(公告)号：NO20032860A

公开(公告)日：2003-08-21

申请号：NO20032860

申请日：2003-06-20

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE ,  SRIRAM RAJARAM

IPC: C07D407/14 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10

CPC classification number: A61K31/495 ,  A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  A61K31/496

公开(公告)号：HU0501030A2

公开(公告)日：2007-02-28

申请号：HU0501030

申请日：2001-12-20

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE ,  SRIRAM RAJARAM

IPC: A61K9/10 ,  C07D407/14 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10