公开(公告)号：HK1143331A1

公开(公告)日：2010-12-31

申请号：HK10109145

申请日：2010-09-24

Applicant: BAXTER INT

Inventor： BREILLATT JULIAN ,  WOO LECON ,  SANDFORD CRAIG ,  BOGGS DANIEL R ,  KHARE ATUL ,  STERNBERG SHMUEL

IPC: A61L20060101 ,  A61L2/00 ,  A61L2/10 ,  A61M20060101 ,  A61M1/02 ,  A61M1/36

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

公开(公告)号：DK1263480T3

公开(公告)日：2010-05-10

申请号：DK01905092

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： WOO LECON ,  BOGGS DANIEL R ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61M1/02 ,  A61M1/36

公开(公告)号：DE60140998D1

公开(公告)日：2010-02-25

申请号：DE60140998

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： WOO LECON ,  BOGGS DANIEL R ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61M1/02 ,  A61M1/36

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

公开(公告)号：AU4142801A

公开(公告)日：2001-08-07

申请号：AU4142801

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： WOO LECON ,  BOGGS DANIEL R ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

IPC: A61L2/00 ,  A61L2/10 ,  A61M1/02 ,  A61M1/36 ,  A61L2/02

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).