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    2.
    发明专利
    未知

    公开(公告)号：DE60141509D1

    公开(公告)日：2010-04-22

    申请号：DE60141509

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： WOO LECON ,  BOGGS DANIEL R ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

    IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61M1/02 ,  A61M1/36

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION
    3.
    发明专利
    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION 未知

    公开(公告)号：CA2398247C

    公开(公告)日：2008-12-02

    申请号：CA2398247

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： STERNBERG SHMUEL ,  SANDFORD CRAIG ,  BOGGS DANIEL R ,  WOO LECON ,  BREILLATT JULIAN ,  KHARE ATUL

    IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61L2/08 ,  A61M1/02 ,  A61M1/36

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to th e radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows throughthe belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION
    4.
    发明专利
    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION 未知

    公开(公告)号：CA2398247A1

    公开(公告)日：2001-08-02

    申请号：CA2398247

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： BOGGS DANIEL R ,  BREILLATT JULIAN ,  SANDFORD CRAIG ,  KHARE ATUL ,  STERNBERG SHMUEL ,  WOO LECON

    IPC: A61L2/00 ,  A61L2/10 ,  A61M1/02 ,  A61M1/36 ,  A61L2/02

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposu re to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid fl ow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation sourc e (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven b y a roller mechanism (38) in the direction of the fluid flow. As the fluid flo ws through thebelt chamber (22), the flexible vanes (36) provide a squeegee-lik e mechanism to move the fluid through the belt chamber (22) in discrete packet s (40) defined by a pair of vanes (36). As the packets of fluid move through t he belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

    BLOOD COLLECTION SYSTEMS INCLUDING AN INTEGRAL, FLEXIBLE FILTER
    8.
    发明专利
    BLOOD COLLECTION SYSTEMS INCLUDING AN INTEGRAL, FLEXIBLE FILTER 未知

    公开(公告)号：CA2368645C

    公开(公告)日：2010-01-26

    申请号：CA2368645

    申请日：2001-02-01

    Applicant: BAXTER INT

    Inventor： LYNN DANIEL R ,  BREILLATT JULIAN ,  BURNHAM JOHN

    IPC: A61J3/00 ,  B01D29/00 ,  A61J1/10 ,  A61M1/02 ,  A61M1/36 ,  B01D29/01 ,  B01D39/08 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20

    Abstract: Blood collection systems include an integral flexible filter to remove leukocytes from blood components. Filter includes first and second flexible sheets comprising a meltable material, a depth filter medium comprising a meltable material, a peripheral seal joining the sheets directly to the filter medium to encapsulate the filter medium between the first and second sheets where the seal includes a comingled melted matrix comprising material of the sheets and material of the filter medium. Filter also includes inlet and outlet ports and is "non-directional" so each port can be oriented to serve either as an inlet or an outlet port. The filter medium comprises prefilter and postfilter layers each made of fibrous material having a pore size and fiber diameter not suited for leukocyte removal.

    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION
    9.
    发明专利
    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION 未知

    公开(公告)号：CA2398241C

    公开(公告)日：2009-03-31

    申请号：CA2398241

    申请日：2001-01-26

    Applicant: BAXTER INT

    Inventor： BREILLATT JULIAN ,  BOGGS DANIEL R ,  WOO LECON ,  KHARE ATUL ,  SANDFORD CRAIG ,  STERNBERG SHMUEL

    IPC: A61L2/08 ,  A61L2/00 ,  A61L2/10 ,  A61M1/02 ,  A61M1/36

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outl et (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow , which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

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