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公开(公告)号：AT430021T
公开(公告)日：2009-05-15
申请号：AT02708965
申请日：2002-01-04
Applicant: BAXTER INT
Inventor： LING MICHAEL T , HURST WILLIAM , WOO LECON , BINDOKAS ALGIRDAS , RYAN PATRICK , EDWARDS SCOTT , BLOM HENK , KHARE ATUL
IPC: B32B1/08 , F16L11/04 , A61J1/10 , A61J1/14 , A61L29/12 , A61L31/00 , B29C35/08 , B29C65/04 , B32B25/08 , B32B27/08 , B32B27/32 , C08L23/08 , C08L23/10 , C08L23/12 , C08L23/14 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00
Abstract: The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.
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2.发明专利
公开(公告)号：CA2398241C
公开(公告)日：2009-03-31
申请号：CA2398241
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： BREILLATT JULIAN , BOGGS DANIEL R , WOO LECON , KHARE ATUL , SANDFORD CRAIG , STERNBERG SHMUEL
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outl et (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow , which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
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3.发明专利
公开(公告)号：CA2398241A1
公开(公告)日：2001-08-02
申请号：CA2398241
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： BOGGS DANIEL R , WOO LECON , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the flui d within the device. The device (10) comprises a radiation permeable cylindric al tube (12) having a concentric cylindrical rotor (14) disposed therein, there by providing a thin gap (16) therebetween. A top plate (18) having a fluid outl et (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication wi th the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides flu id flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows , the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
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公开(公告)号：AT460185T
公开(公告)日：2010-03-15
申请号：AT01912673
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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公开(公告)号：AT454170T
公开(公告)日：2010-01-15
申请号：AT01905092
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
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Patent Agency Ranking6.发明专利
公开(公告)号：AU3300901A
公开(公告)日：2001-08-07
申请号：AU3300901
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
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7.发明专利
公开(公告)号：ES2340250T3
公开(公告)日：2010-06-01
申请号：ES01905092
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: Dispositivo (110) para inactivar agentes patógenos en fluidos, que comprende: un recipiente (112) permeable a la radiación que comunica con un fluido de una corriente de fluido; una mezcladora (126, 128) dispuesta dentro del recipiente y que forma un intersticio entre la mezcladora (126, 128) y el recipiente (112), una fuente de radiación dispuesta a una distancia fija del recipiente, irradiando la fuente de radiación el fluido que se desplaza a través del recipiente, caracterizado porque la mezcladora comprende una superficie en cascada (128) y, a causa de su geometría, produce una turbulencia dentro del flujo de fluido que se desplaza a través del intersticio; y la fuente de radiación se selecciona entre el grupo consistente en radiación ultravioleta, gamma y por haz electrónico.
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公开(公告)号：DE60141509D1
公开(公告)日：2010-04-22
申请号：DE60141509
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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9.发明专利
公开(公告)号：CA2398247C
公开(公告)日：2008-12-02
申请号：CA2398247
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL , SANDFORD CRAIG , BOGGS DANIEL R , WOO LECON , BREILLATT JULIAN , KHARE ATUL
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to th e radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows throughthe belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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10.发明专利
公开(公告)号：CA2398247A1
公开(公告)日：2001-08-02
申请号：CA2398247
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： BOGGS DANIEL R , BREILLATT JULIAN , SANDFORD CRAIG , KHARE ATUL , STERNBERG SHMUEL , WOO LECON
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposu re to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid fl ow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation sourc e (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven b y a roller mechanism (38) in the direction of the fluid flow. As the fluid flo ws through thebelt chamber (22), the flexible vanes (36) provide a squeegee-lik e mechanism to move the fluid through the belt chamber (22) in discrete packet s (40) defined by a pair of vanes (36). As the packets of fluid move through t he belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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