公开(公告)号：NO20055616D0

公开(公告)日：2005-11-28

申请号：NO20055616

申请日：2005-11-28

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  SUN CHONG-SON ,  PAPADOPOULOS PAVLOS ,  RABINOW BARRETT E ,  WHITE RANDY

IPC: A61K9/50 ,  A61K9/51 ,  A61K31/496 ,  A61K

Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 µm as measured by laser diffractonetry.

公开(公告)号：NO20052285D0

公开(公告)日：2005-05-10

申请号：NO20052285

申请日：2005-05-10

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  PAPADOPOULOS PAVLOS

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K31/495 ,  A61K31/496 ,  A61K

Abstract: The present invention relates to compositions of submicron-to micron-size particles of antifungal agents. More particularly the invention relates to aqueous suspensions of antifungal agents for pharmaceutical use.

公开(公告)号：CA2523151A1

公开(公告)日：2004-11-11

申请号：CA2523151

申请日：2004-04-29

Applicant: BAXTER INT

Inventor： RABINOW BARRETT E ,  WHITE RANDY ,  PAPADOPOULOS PAVLOS ,  REBBECK CHRISTINE L ,  SUN CHONG-SON ,  KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J

IPC: A61K9/50 ,  A61K9/51 ,  A61K31/496 ,  A61K9/14

Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates t o a composition of an antimicrobial agent that renders the agent potent agains t organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles ha ve a volume-weighted mean particle size of less than 5 ~m as measured by laser diffractonetry.

公开(公告)号：CA2498488A1

公开(公告)日：2004-04-22

申请号：CA2498488

申请日：2003-10-02

Applicant: BAXTER INT

Inventor： PAPADOPOULOS PAVLOS ,  REBBECK CHRISTINE L ,  DOTY MARK J ,  KIPP JAMES E ,  WONG JOSEPH CHUNG TAK

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K31/495 ,  A61K31/496

Abstract: The present invention relates to compositions of submicron- to micron-size particles of antifungal agents. More particularly the invention relates to aqueous suspensions of antifungal agents for pharmaceutical use.

公开(公告)号：AU2005304952B2

公开(公告)日：2013-04-04

申请号：AU2005304952

申请日：2005-11-03

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： PAPADOPOULOS PAVLOS ,  DOTY MARK ,  KIPP JAMES E ,  ROESSLER BERTHOLD

IPC: A61K31/404 ,  A61K9/00 ,  A61P35/00

Abstract: The present invention is directed to novel pharmaceutical compositions comprinsing nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin”, and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.

公开(公告)号：MX2007005434A

公开(公告)日：2007-07-10

申请号：MX2007005434

申请日：2005-11-03

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  PAPADOPOULOS PAVLOS ,  DOTY MARK ,  ROESSLER BERTHOLD

IPC: A61K9/00 ,  A61K31/404 ,  A61P35/00

Abstract: La presente invencion se dirige a composiciones farmaceuticas novedosas que comprenden formulaciones de nano y microparticulado de inhibidores de tubulina deficientemente solubles en agua de la clase de quimicos de indole, preferentemente indol-3-glioxiamidas sustituidos-N y mas preferentemente, amida de acido N-(Piridin-4-il)-[1-(4- clorobencil)indole-3-il]glioxilico (D-24851), tambien conocidos como "Indibulin" y metodos para elaborar y utilizar dichas composiciones para el tratamiento de canceres resistentes a agentes anti-tumor y otras enfermedades.

公开(公告)号：CA2587276A1

公开(公告)日：2006-05-18

申请号：CA2587276

申请日：2005-11-03

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： PAPADOPOULOS PAVLOS ,  DOTY MARK ,  KIPP JAMES E ,  ROESSLER BERTHOLD

IPC: A61K31/404 ,  A61K9/00 ,  A61P35/00

Abstract: The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.

公开(公告)号：NO20055616L

公开(公告)日：2006-01-25

申请号：NO20055616

申请日：2005-11-28

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  SUN CHONG-SON ,  PAPADOPOULOS PAVLOS ,  RABINOW BARRETT E ,  WHITE RANDY

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K31/496

Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 µm as measured by laser diffractonetry.

公开(公告)号：NO20055616A

公开(公告)日：2006-01-25

申请号：NO20055616

申请日：2005-11-28

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  SUN CHONG-SON ,  PAPADOPOULOS PAVLOS ,  RABINOW BARRETT E ,  WHITE RANDY

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K31/496

CPC classification number: A61K9/5123 ,  A61K9/5015 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/496

公开(公告)号：MXPA05011607A

公开(公告)日：2005-12-15

申请号：MXPA05011607

申请日：2004-04-29

Applicant: BAXTER INT

Inventor： PAPADOPOULOS PAVLOS

IPC: A61K9/50 ,  A61K9/51 ,  A61K31/496 ,  A61K9/14

Abstract: La presente invencion se refiere a composiciones de particulas con tamano de submicron a micron de agentes antimicrobianos. Mas particularmente, la invencion se refiere a una composicion de un agente antimicrobiano que produce el agente potente contra organismos normalmente considerados resistentes al agente. La composicion comprende una suspension acuosa de particulas con tamano de submicron a micron conteniendo el agente revestido con al menos un surfactante seleccionada del grupo que consiste de: surfactantes ionicos, surfactantes no ionicos, surfactantes biologicamente derivados, y aminoacidos y sus derivados. Las particulas tienen un tamano de particula promedio pesado en volumen menor a 5°m segun se mide por difractometria laser.