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11.发明申请
公开(公告)号：WO2006080986A3
公开(公告)日：2006-11-30
申请号：PCT/US2005044378
申请日：2005-12-08
Applicant: BIO RAD LABORATORIES , BERKELMAN THOMAS R
Inventor： BERKELMAN THOMAS R
CPC classification number: C09B23/105 , C09B23/107 , G01N33/582 , G01N33/6803 , G01N2458/00
Abstract: Protein dyes whose molecular structure is that of a coumarin moiety coupled to a quaternary ammonium heterocycle through a vinyl or polyvinyl linkage demonstrate the ability to associate with proteins in a non-covalent, non-specific manner at low pH, where the associated form displays a significantly higher fluorescence emission than the unassociated form. This makes the dyes useful as selective labels for proteins at the low pH and eliminates the need for the removal of extraneous components from the medium in which the proteins reside prior to detection.
Abstract translation: 其分子结构是通过乙烯基或聚乙烯基键连接到季铵杂环的香豆素部分的蛋白质染料证明了在低pH下以非共价，非特异性方式与蛋白质缔合的能力，其中相关联的形式显示 荧光发射明显高于非相关形式。 这使得染料可用作蛋白质在低pH下的选择性标记，并且不需要从检测前蛋白质存在的培养基中去除外来成分。
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Patent Agency Ranking12.发明公开CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES 有权1,4,7-三氮杂CYCLONONANEN，双核金属络合物从这样的偶联物及其申请程序1,4,7-三氮杂环壬和结合物结合物
公开(公告)号：EP2547666A4
公开(公告)日：2013-09-18
申请号：EP11756750
申请日：2011-03-09
Applicant: BIO RAD LABORATORIES
Inventor： BERKELMAN THOMAS R , MARTIN LISANDRA , JONES RHIANNON , WALKER II JOHN
IPC: C07D255/02 , B01D15/00 , G01N30/00 , G01N33/00
CPC classification number: G01N27/44747 , B01D15/3823 , C07D255/02 , C07F3/06 , C07F13/005 , C08F220/56 , C08F220/60 , G01N33/54306 , Y10T436/143333 , Y10T436/163333
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公开(公告)号：EP2318839A4
公开(公告)日：2014-11-26
申请号：EP09812131
申请日：2009-09-02
Applicant: BIO RAD LABORATORIES
Inventor： ROWELL CRAIG , PANATTONI CORY , BERKELMAN THOMAS R , CATER SEAN , PETERSEN SHANE , OLECH LEE , YANG XUEMEI
IPC: G01N33/558 , B01D57/02 , G01N27/447 , G01N33/559 , G01N33/561
CPC classification number: G01N27/44747 , B01D57/02 , C08F220/56 , C08F222/385
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14.发明公开CYCLOMETALATED TRANSITION METAL COMPLEXES FOR MULTIPLEX ANALYTE DETECTION 审中-公开圆锥滚子ÜBERGANGSMETALLKOMPLEXEFÜRMULTIPLEXEN ANALYTNACHWEIS
公开(公告)号：EP2364318A4
公开(公告)日：2012-08-01
申请号：EP09830962
申请日：2009-12-01
Applicant: BIO RAD LABORATORIES
Inventor： BERKELMAN THOMAS R
CPC classification number: C07F15/0033 , C09B57/00 , C09B57/008 , C09B57/10 , G01N33/52 , G01N33/6803
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公开(公告)号：EP1842059A4
公开(公告)日：2010-05-26
申请号：EP05853322
申请日：2005-12-08
Applicant: BIO RAD LABORATORIES
Inventor： BERKELMAN THOMAS R
CPC classification number: C09B23/105 , C09B23/107 , G01N33/582 , G01N33/6803 , G01N2458/00
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公开(公告)号：EP2057508A4
公开(公告)日：2010-02-24
申请号：EP07814469
申请日：2007-08-27
Applicant: BIO RAD LABORATORIES
Inventor： BERKELMAN THOMAS R , YARMOLUK SERGIY M , KOVALSKA VLADYSLAVA B , LOSYTSKYY MYKHAYLO YU , VOLKOVA KATERYNA D
CPC classification number: G01N33/6839 , C09B23/0066 , C09B57/007 , G01N2458/30
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