公开(公告)号：DE69332634T2

公开(公告)日：2003-05-08

申请号：DE69332634

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10 ,  C07D473/08 ,  G01N33/536

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：NO943263L

公开(公告)日：1994-11-02

申请号：NO943263

申请日：1994-09-02

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：CA2112239A1

公开(公告)日：1993-09-16

申请号：CA2112239

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：ES2191013T3

公开(公告)日：2003-09-01

申请号：ES93908327

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10 ,  C07D473/08 ,  A61P37/00

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：AU1950899A

公开(公告)日：1999-07-26

申请号：AU1950899

申请日：1999-01-04

Applicant: CELL THERAPEUTICS INC

Inventor： KLEIN J PETER ,  KUMAR ANIL M ,  WOODSON PAUL

IPC: C07D473/04 ,  A61K31/52

Abstract: A new class of xanthine compounds, variously substituted at the 1, 3, 7 and 8 positions, is characterized by an ability to modulate the activity of key enzymes involved in drug metabolism. These compounds generally are useful in affecting drug metabolism and, particularly, in extending the circulating half-life of compounds that are metabolized via P-450-mediated pathways.

公开(公告)号：CZ212394A3

公开(公告)日：1995-09-13

申请号：CZ212394

申请日：1994-09-02

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：EP0669825A4

公开(公告)日：1996-04-03

申请号：EP94902300

申请日：1993-11-16

Applicant: CELL THERAPEUTICS INC

Inventor： UNDERINER GAIL E ,  PORUBEK DAVID ,  KLEIN PETER J ,  WOODSON PAUL

IPC: A61K31/519 ,  C07C233/91 ,  C07C317/18 ,  C07D209/48 ,  C07D211/76 ,  C07D211/88 ,  C07D215/22 ,  C07D239/54 ,  C07D239/88 ,  C07D239/96 ,  C07D295/088 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D475/02 ,  A61K31/53 ,  A61K31/10 ,  A61K31/16 ,  A61K31/40 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/515 ,  A61K31/52 ,  C07D251/00 ,  C07D253/00

CPC classification number: C07D209/48 ,  A61K31/519 ,  C07C233/91 ,  C07C317/18 ,  C07D211/76 ,  C07D211/88 ,  C07D215/22 ,  C07D239/54 ,  C07D239/88 ,  C07D239/96 ,  C07D295/088 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D475/02

公开(公告)号：EP0584347A4

公开(公告)日：1995-04-26

申请号：EP93908327

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10

CPC classification number: A61K31/522 ,  A61K31/519 ,  A61K31/52 ,  C07D473/10 ,  Y02P20/582 ,  Y10S514/814 ,  Y10S514/866 ,  Y10S514/921

公开(公告)号：PT584347E

公开(公告)日：2003-06-30

申请号：PT93908327

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10 ,  C07D473/08 ,  A61P37/00

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.

公开(公告)号：AT230990T

公开(公告)日：2003-02-15

申请号：AT93908327

申请日：1993-03-01

Applicant: CELL THERAPEUTICS INC

Inventor： BIANCO JAMES A ,  WOODSON PAUL ,  PORUBEK DAVID ,  SINGER JACK

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/44 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/06 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P19/10 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  A61P39/02 ,  A61P43/00 ,  C07D473/04 ,  C07D473/10 ,  C07D473/08 ,  A61P37/00

Abstract: There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an omega -1 alcohol of a straight chain alkyl (C5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.