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    PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES
    11.
    发明专利
    PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES 未知

    公开(公告)号：CA1262400A

    公开(公告)日：1989-10-17

    申请号：CA267474

    申请日：1976-12-08

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  SELE ALEX

    IPC: C07H3/02 ,  A61K31/195 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7028 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07H13/08 ,  C07H15/00 ,  C07H15/04 ,  C07K1/113 ,  C07K9/00

    Abstract: PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES A glucosamine derivative of the general formula (I) in which X denotes a carbonyl or sulphonyl group, R denotes an optionally substituted alkyl radical or an optionally substituted carbocyclic aryl radical and, if X is the carbonyl group, also denotes an alkoxy or benzyloxy radical, R1 denotes hydrogen, alkyl or an optionally substituted benzyl radical, R2 denotes hydrogen or Lower alkyl, R4 and R6 denote hydrogen, alkyl or an optionally substituted benzyl or an acyl radical, R7 denotes hydrogen, alkyl, hydroxymethyl, mercaptomethyl or phenyl, R8 denotes an optionally esterified or amidised carboxyl group and R9 denotes an optionally esterified or amidised carboxyl group, with the proviso that the optionally substituted alkyl radical R has more than 1 carbon atom if X denotes the carbonyl group and the radical R2 denotes methyl; or, if X denotes the carbonyl group, the radical R2 represents hydrogen and R8 and R9 each represent a carboxyl group, and its salts. They have immunity-boosting action.

    ACYLATED HEXOSE DERIVATIVE
    12.
    发明专利
    ACYLATED HEXOSE DERIVATIVE 未知

    公开(公告)号：PH23120A

    公开(公告)日：1989-05-05

    申请号：PH33428

    申请日：1986-02-18

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  STANEK JAROSLAV ,  WACKER OSKAR ,  HARTMANN ALBERT

    IPC: C07K9/00 ,  C07C101/22 ,  A61K31/70

    Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R is lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R and R are, independently of one another, hydrogen, lower alkanoyl or benzoyl, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino or lower alkoxy, R is hydrogen, carboxyl or lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, lower alkanoylamino-, hydroxyl-, guanidino-, lower alkanoyloxy-, 2-benzyloxycarbonylamino- ethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower- alkoxycarbonylaminoethylsulphinyl- or 2-lower-alkoxycarbonylamino- ethylsulphonyl-substituted lower alkyl, with the proviso that in the compounds in which the pyranose moiety is derived from D-glucose and, at the same time, n is 0, R , R and R are hydrogen, R is methyl, R is amino and R is hydroxyl, and in which the radicals R , R and R all have the same meaning, R , R and R are different from acetyl and butyryl when R is phenyl and, at the same time, R is hydrogen, and that R , R and R are different from acetyl when R and R are both methyl, and these compounds and salts thereof where appropriate have an antiviral action in vivo.

    14.
    发明专利
    未知

    公开(公告)号：FI75578B

    公开(公告)日：1988-03-31

    申请号：FI802294

    申请日：1980-07-21

    Applicant: CIBA GEIGY AG

    Inventor： TARCSAY LAJOS ,  HARTMANN ALBERT ,  BASCHANG GERHARD ,  STANEK JAROSLAV

    IPC: C07H13/00 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07K1/06 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07K5/02 ,  C07H15/04 ,  C07F9/09

    Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.

    ACYLATED HEXOSE DERIVATIVES OF DI AND TRIPEPTIDES
    19.
    发明专利
    ACYLATED HEXOSE DERIVATIVES OF DI AND TRIPEPTIDES 未知

    公开(公告)号：AU5376886A

    公开(公告)日：1986-08-28

    申请号：AU5376886

    申请日：1986-02-19

    Applicant: CIBA GEIGY AG

    Inventor： WACKER OSKAR ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  FEICHTIG BRUNO ,  BASCHANG GERHARD

    IPC: C07K9/00 ,  C07K5/06 ,  C07K5/02 ,  A61K31/70 ,  A61K37/02

    Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R , R and R are, independently of one another, lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino, C1-10-alkoxy, aryl-lower alkoxy, alkanoyloxy-lower alkoxy with up to 16 C atoms, aroyloxy-lower alkoxy, 3-cholesteryloxy or 2-trimethylammonioethyloxy, R is hydrogen, carboxyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, hydroxyl-, lower alkanoylamino-, lower alkanoyloxy-, 2-benzyloxycarbonylaminoethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower-alkoxycarbonyl- aminoethylsulphinyl-, 2-lower-alkoxycarbonylaminoethylsulphonyl- or guanidino-substituted lower alkyl, with the proviso that at least one of the radicals R and R is different from hydroxyl, amino and C1-7-alkoxy or R is different from hydrogen, carboxyl and alkoxycarbonyl with up to 7 C atoms in the alkoxy moiety, and these compounds and salts thereof where appropriate can be used for the prophylaxis and therapy of viral infections.

    20.
    发明专利
    未知

    公开(公告)号：NO860624L

    公开(公告)日：1986-08-21

    申请号：NO860624

    申请日：1986-02-19

    Applicant: CIBA GEIGY AG

    Inventor： WACKER OSKAR ,  STANEK JAROSLAV ,  FECHTIG BRUNO ,  BASCHANG GERHARD ,  HARTMANN ALBERT

    IPC: C07K9/00 ,  C07K

    Abstract: The derivatives have the formula I in which the hexose moiety is derived from D-glucose, D-mannose or D-galactose, n is 0 or 1, and R , R and R are, independently of one another, lower alkanoyl or benzoyl, R is lower alkyl or phenyl, R , R and R are, independently of one another, hydrogen or lower alkyl, or R and R together are trimethylene and R is hydrogen, R is hydrogen or unsubstituted or phenyl-, hydroxyl-, mercapto- or lower alkylthio-substituted lower alkyl, R and R are, independently of one another, hydroxyl, amino, C1-10-alkoxy, aryl-lower alkoxy, alkanoyloxy-lower alkoxy with up to 16 C atoms, aroyloxy-lower alkoxy, 3-cholesteryloxy or 2-trimethylammonioethyloxy, R is hydrogen, carboxyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl and R is hydrogen or unsubstituted or amino-, hydroxyl-, lower alkanoylamino-, lower alkanoyloxy-, 2-benzyloxycarbonylaminoethylsulphinyl-, 2-benzyloxycarbonylaminoethylsulphonyl-, 2-lower-alkoxycarbonyl- aminoethylsulphinyl-, 2-lower-alkoxycarbonylaminoethylsulphonyl- or guanidino-substituted lower alkyl, with the proviso that at least one of the radicals R and R is different from hydroxyl, amino and C1-7-alkoxy or R is different from hydrogen, carboxyl and alkoxycarbonyl with up to 7 C atoms in the alkoxy moiety, and these compounds and salts thereof where appropriate can be used for the prophylaxis and therapy of viral infections.

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