公开(公告)号：US20240035976A1

公开(公告)日：2024-02-01

申请号：US17920640

申请日：2021-04-21

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/64 ,  G01N21/65 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01N21/65 ,  G01N21/6402 ,  G01N33/4833 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A method and system of analyzing a resected tissue specimen is provided. The method includes: a) using an imaging system to image a tissue sample with excitation light configured to produce fluorescent emissions from the tissue sample, the imaging producing signals representative of the fluorescent emissions from the sample; b) determining a presence or an absence of at least one suspect tissue region on the tissue sample; c) determining a spatial location of said at least one suspect tissue region determined to be present on the tissue sample; d) using the imaging system to image the suspect tissue region at the determined spatial location with excitation light configured to produce Raman scattering from the sample, the imaging producing signals representative of the Raman scattering from sample; and e) analyzing the determined suspect tissue region using the signals representative of the Raman scattering from the sample.

公开(公告)号：US20240011969A1

公开(公告)日：2024-01-11

申请号：US18271023

申请日：2022-01-05

Applicant: CytoVeris Inc.

Inventor： Rishikesh Pandey ,  David Fournier ,  Patrick Curry ,  Alan Kersey

IPC: G01N33/483 ,  G01N21/64

CPC classification number: G01N33/4833 ,  G01N21/6486 ,  A61B10/00

Abstract: A system and method for analyzing bladder tissue sample is provided that includes an excitation light source, a photodetector, an optical filter, and a system controller. The excitation light source produces excitation lights centered on a distinct wavelengths. At least one of the wavelengths produces autofluorescence emissions from one or more biomolecules, and at least one of the wavelengths produces diffuse reflectance signals. The photodetector detects at least one of the autofluorescence emissions or diffuse reflectance signals and produces signals representative thereof. The optical filter filters at least one of autofluorescence emissions or the diffuse reflectance signals. The system controller communicates with the system components and a memory storing instructions. The instructions cause the system controller to control the excitation light unit, receive and process the photodetector signals, produce a signal image, and analyze the tissue sample to determine the presence of detrusor muscle tissue.

公开(公告)号：US20230366821A1

公开(公告)日：2023-11-16

申请号：US18027022

申请日：2021-09-17

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/64 ,  G01N21/47

CPC classification number: G01N21/6456 ,  G01N21/6486 ,  G01N21/4738 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2223/401 ,  G01N2800/7028

Abstract: A method and system for analyzing a tissue sample is provided. The method includes: a) sequentially interrogating a tissue sample with excitation lights, wherein at least one of the excitation lights is configured to produce autofluorescence emissions from one or more biomolecules of interest, and diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the autofluorescence emissions and/or the diffuse reflectance signals from the tissue sample, and to produce photodetector signals representative of the detected said autofluorescence emissions and/or the detected said diffuse reflectance signals; c) filtering the light emitted or reflected from the tissue sample; d) processing the photodetector signals for each sequential application of excitation light, including producing an image representative of the photodetector signals produced by each sequential application of excitation light; and e) analyzing the tissue sample using each image to identify the presence of diseased tissue within the tissue sample.

公开(公告)号：US11441949B2

公开(公告)日：2022-09-13

申请号：US17222858

申请日：2021-04-05

Applicant: CytoVeris Inc.

Inventor： Gary Root ,  David Fournier ,  Rishikesh Pandey

IPC: G01N15/02 ,  G01J3/44 ,  A61B5/00 ,  G06N3/04

Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.

公开(公告)号：US20220284603A1

公开(公告)日：2022-09-08

申请号：US17687283

申请日：2022-03-04

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Kevin Didden ,  Alan Kersey

IPC: G06T7/30 ,  G06T19/00 ,  G16H10/40

Abstract: A system and method of producing an image-based registration of an excised tissue specimen for histopathological examination is provided. The method includes: a) producing a three-dimensional image of an excised tissue specimen having a plurality of surfaces at a first location, the excised tissue specimen having an in-vivo orientation prior to being excised; b) producing orientation information relating to the orientation of the plurality of surfaces of the excised tissue specimen relative to the in-vivo orientation of the tissue specimen prior to being excised; c) wherein the excised tissue specimen is transported to a second location and is positioned; and d) using the three-dimensional image and the orientation information to confirm the excised tissue specimen positioned at the second location is in the in-vivo orientation.

公开(公告)号：US20220128477A1

公开(公告)日：2022-04-28

申请号：US17513824

申请日：2021-10-28

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/543 ,  A61B5/00

Abstract: A system and method for assaying high and low abundant biomolecules within a biological fluid sample is provided. The method includes: a) placing a biological fluid sample in contact with a first nanostructure surface; b) interrogating the sample with a light source, the sample in contact with the first nanostructure surface, the interrogation using a SERS technique; c) detecting an enhanced Raman scattering from at least one high abundant biomolecule type and producing first signals representative thereof; d) placing the sample in contact with a second nanostructure surface having a targeting agent that targets a low abundant biomolecule; e) interrogating the sample with the light source using the SERS technique; f) detecting the enhanced Raman scattering from the low abundant biomolecules and producing second signals representative thereof; and g) assaying the biological fluid sample using the first signals and the second signals.