公开(公告)号：DE3113449A1

公开(公告)日：1982-11-11

申请号：DE3113449

申请日：1981-04-03

Applicant: HOECHST AG

Inventor： WINKELMANN ERHARDT DIPL CHEM D ,  DITTMAR WALTER DR ,  RAETHER WOLFGANG DR

IPC: A61K31/27 ,  A61K31/38 ,  A61K31/47 ,  A61P31/04 ,  C07C67/00 ,  C07C325/00 ,  C07C333/08 ,  C07D215/20 ,  C07D277/62 ,  C07D277/68 ,  C07D295/135 ,  C07D333/54 ,  C07C155/02 ,  A61K31/185 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  C07D295/12

公开(公告)号：DE3042785A1

公开(公告)日：1982-06-09

申请号：DE3042785

申请日：1980-11-13

Applicant: HOECHST AG

Inventor： WINKELMANN ERHARDT DR ,  DITTMAR WALTER DR ,  RAETHER WOLFGANG DR

IPC: C07D215/20 ,  C07D217/02 ,  C07D277/62 ,  C07D333/54 ,  A61K31/325 ,  A61K31/38 ,  A61K31/425 ,  A61K31/47

Abstract: Thiocarbamate esters of formula (I) are new. R1 is H, Me, hydroxymethyl, MeO, OH, MeS, F, Cl, Br, CF3, and is pref. in 3-posn; R2 is H, Me, F, Cl and is pref. in 4- or 5-posn.; R3 is Me or Et; R4 is quinoline, isoquinoline, benzothiophene, benzothiazole attached via the benzene ring to the O atom. (I) can be used to treat fungal skin infections. (I) are esp. effective against e.g. Trichophyton mentagrophytes, Microsporon canis, Aspergillus niger. (I) are more effective than tolnaftat.

公开(公告)号：DE3867546D1

公开(公告)日：1992-02-20

申请号：DE3867546

申请日：1988-06-10

Applicant: HOECHST AG

Inventor： BOHN MANFRED DR ,  DITTMAR WALTER DR ,  KRAEMER KARL DR ,  PEIL HEINZ GEORG DR ,  FUTTERER EBERHARD DR

IPC: A61K31/41 ,  A61K8/00 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K9/70 ,  A61K31/13 ,  A61K31/135 ,  A61K31/27 ,  A61K31/325 ,  A61K31/415 ,  A61P17/00 ,  A61P31/04 ,  A61P31/10 ,  A61Q3/02 ,  A61K7/043

Abstract: Nail varnish comprises a water-insoluble film former (I) and at least 1 antimycotic agent (II). (I) is polyvinyl acetate (opt. partially hydrolysed); copolymer of vinyl acetate (VA) with acrylic acid, crotonic acid (CA) or monoalkyl maleate (MAM); terpolymer of VA, CA and vinyl neodecanoate or vinyl propionate; copolymer of methyl vinyl ether and MAM; copolymer of vinyl fatty acid ester and (meth)acrylic acid; copolymer of N-vinylpyrrolidone, methacrylic acid and alkyl methacrylate; copolymer of acrylic acid and methacrylic acid or alkyl (meth)acrylate; polyvinyl acetals; polyvinyl butyrals; alkyl-substd. poly-N-vinylpyrrolidone, and alkyl esters of olefin-maleic anhydride copolymers. (II) is tioconazole (IIa); econazole (IIb); oxiconazole; miconazole; tolnaftate or naftifine hydrochloride. Pref. (I) is 2-80 (esp. 20-40) wt.% of non-volatile components and 0.5-20 (esp. 2-15) wt.% of the total formulation.

公开(公告)号：DE3608727A1

公开(公告)日：1987-09-17

申请号：DE3608727

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： EHRHARDT HEINZ DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07C41/00 ,  A01N43/50 ,  A01N43/653 ,  A61K31/12 ,  A61K31/13 ,  A61K31/41 ,  A61K31/495 ,  C07C49/175 ,  C07C49/84 ,  C07C67/00 ,  C07C201/00 ,  C07C205/59 ,  C07C213/00 ,  C07D213/70 ,  C07D233/56 ,  C07D233/60 ,  C07D239/38 ,  C07D249/08 ,  C07D295/10 ,  C07D295/116 ,  C07D307/38 ,  C07D333/28 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C07C149/34

Abstract: Compounds I where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, fluorenyl, thienyl, furyl, pyridyl, isoxazolyl, pyrazolyl, benzofuryl or benzothienyl, Z equals CO, CH2 or radicals of ketone derivatives; Y equals azole or equals -X-R8 (R8=(cyclo)alkyl or an aromatic) or equals a number of amine derivatives or equal acyl, are antimycotics. The preparation and use as medicaments are described.

公开(公告)号：DE3402166A1

公开(公告)日：1985-07-25

申请号：DE3402166

申请日：1984-01-23

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  ALPERMANN HANS GEORG DR ,  SACHSE BURKHARD DR ,  HARTZ PETER DR

IPC: A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  A61P31/04 ,  B27K3/38 ,  C07C45/60 ,  C07C49/84 ,  C07D233/60 ,  C07D249/08 ,  C07D295/096 ,  C07D295/185 ,  C07D333/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C09D5/14 ,  C07D403/10

Abstract: Azolyl derivatives of the formula I where A = CH or N; n = 2 - 12; Ar = aromatic; R = alkyl, alkenyl, alkynyl or benzyl; and Q = -S(O)1-3R or -OR (R = alkyl, cycloalkyl, alkenyl and some aromatics; R = saturated or unsaturated alkyl, cycloalkyl, cycloalkylalkyl, aromatics) and processes for their preparation are described. They are antimicrobial agents active against fungal infections. The intermediates of the formula VIIa have antidepressive properties.

公开(公告)号：GR850174B

公开(公告)日：1985-05-13

申请号：GR850100174

申请日：1985-01-22

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  ALPERMANN HANS GEORG DR ,  SACHSE DURKARD DR ,  HARTZ PETER DR

IPC: A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  A61P31/04 ,  B27K3/38 ,  C07C45/60 ,  C07C49/84 ,  C07D233/60 ,  C07D249/08 ,  C07D295/096 ,  C07D295/185 ,  C07D333/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C09D5/14

Abstract: Azolyl derivatives of the formula I where A = CH or N; n = 2 - 12; Ar = aromatic; R = alkyl, alkenyl, alkynyl or benzyl; and Q = -S(O)1-3R or -OR (R = alkyl, cycloalkyl, alkenyl and some aromatics; R = saturated or unsaturated alkyl, cycloalkyl, cycloalkylalkyl, aromatics) and processes for their preparation are described. They are antimicrobial agents active against fungal infections. The intermediates of the formula VIIa have antidepressive properties.

公开(公告)号：DE3239170A1

公开(公告)日：1984-04-26

申请号：DE3239170

申请日：1982-10-22

Applicant: HOECHST AG

Inventor： WINKELMANN ERHARDT DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D317/18 ,  C07D317/20 ,  C07D521/00 ,  C07D405/06 ,  A01N43/50 ,  A01N43/64 ,  A61K7/40 ,  A61K31/41 ,  A61K31/415 ,  C07D405/14

Abstract: 1-(1,3-Dioxolan-2-yl-methyl)-1H-imidazoles and -1H-1,2,4-triazoles of the formula I and their salts with physiologically acceptable acids as well as processes for their preparation are described. The novel compounds are active against infections caused by fungi such as dermatophytes, moulds and yeasts, by Protozoa such as trichomonads, and by bacteria.

公开(公告)号：DE3039087A1

公开(公告)日：1982-05-19

申请号：DE3039087

申请日：1980-10-16

Applicant: HOECHST AG

Inventor： BLUME ERNST DR ,  SCHAPER WOLFGANG DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D217/04 ,  C07D233/60 ,  C07D295/096 ,  C07D295/185 ,  C07D295/26 ,  C07D317/20 ,  C07D317/22 ,  C07D317/24 ,  C07D333/28 ,  C07D521/00 ,  C07D405/06 ,  C07D405/14 ,  A61K31/415 ,  A61K31/41

Abstract: 1-(1,3-Dioxolan-2-ylmethyl)-azoles of the general formula and their stereoisomers and their salts with physiologically acceptable acids, the preparation of these compounds, pharmaceutical formulations containing the latter and their use against mycoses, protozoa and Gram-positive and Gram-negative bacteria are described.

公开(公告)号：DE2234009A1

公开(公告)日：1974-01-24

申请号：DE2234009

申请日：1972-07-11

Applicant: HOECHST AG

Inventor： DITTMAR WALTER DR ,  FUTTERER EBERHARD DR ,  LOHAUS GERHARD DR

IPC: A61K8/00 ,  A61K20060101 ,  A61K8/33 ,  A61K8/37 ,  A61K8/49 ,  A61K8/92 ,  A61K31/12 ,  A61K31/44 ,  A61P17/08 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q7/00 ,  C07D20060101 ,  C07D207/26 ,  C07D213/89 ,  C11D3/28 ,  C11D3/48 ,  A61K7/08

Abstract: A cosmetic composition comprising a content of an 1-hydroxy-2-pyridone of the general formula in which R1 stands for hydrogen, alkyl of 1 to 17 carbon atoms, alkenyl of 2 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, bicycloalkyl of 7 to 9 carbon atoms, cycloalkyl-alkyl of 1 to 4 alkyl carbon atoms, the cycloalkyl groups being optionally substituted by alkyl groups of 1 to 4 carbon atoms, aryl, aralkyl of 1 to 4 alkyl carbon atoms, aryl-alkenyl of 2 to 4 alkenyl carbon atoms, aryloxy-alkyl or arylthio-alkyl of 1 to 4 alkyl carbon atoms, benzhydryl, phenylsulfonyl-alkyl of 1 to 4 alkyl carbon atoms, furyl or furyl-alkenyl of 2 to 4 alkenyl carbon atoms, the aryl groups being optionally substituted by alkyl of 1 to 4 carbon atoms, by alkoxy of 1 to 4 carbon atoms, by nitro, cyano or halogen atoms, R2 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, halogen atoms or benzyl, R3 stands for hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, and R4 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, methoxy-methyl, halogen or benzyl, and/or salt thereof, which may be used as an anti-dandruff agent.

公开(公告)号：DE1793471A1

公开(公告)日：1971-07-01

申请号：DE1793471

申请日：1968-09-23

Applicant: HOECHST AG

Inventor： RIPPEL ROBERT DR ,  DITTMAR WALTER DR ,  SCHORR MANFRED DR

IPC: C07D333/36 ,  C07D333/38 ,  C07D63/12

Abstract: Thiophene-3-isonitriles of the formula IN WHICH R1 is hydrogen, alkyl, carbalkoxy, cyano or phenyl, R2 is hydrogen, alkyl, alkoxy, carbalkoxy, cyano or phenyl, R3 is hydrogen, alkyl, carbalkoxy or phenyl, or R2 and R3 together represent an alkylene chain, are disclosed as having antimycotic and antibacterial properties.