公开(公告)号：DE3883919D1

公开(公告)日：1993-10-14

申请号：DE3883919

申请日：1988-11-04

Applicant: HOECHST AG

Inventor： HEISE HARTMUT DR ,  HINTZMANN MANFRED DR

IPC: C07B61/00 ,  B01J31/02 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/19 ,  C07C205/37

Abstract: O-Nitrophenetol is prepared by exposing 1 mol of o-nitrochlorobenzene to the action of about 1.05 to about 1.4 mol of ethanol in the presence of a phase-transfer catalyst in about 40 to about 70 per cent strength by weight alkali metal hydroxide solution at temperatures of about 50 to about 80 DEG C in such a manner that the ethanol concentration of the reaction mixture does not exceed 1.5 per cent by weight during the entire course of the reaction.

公开(公告)号：DE3480598D1

公开(公告)日：1990-01-04

申请号：DE3480598

申请日：1984-06-01

Applicant: HOECHST AG

Inventor： HEISE HARTMUT DR ,  HINTZMANN MANFRED DR ,  BRUECKMANN KONRAD

IPC: C07C69/95 ,  C07C67/343 ,  C07C69/757

公开(公告)号：DE3804621A1

公开(公告)日：1989-08-24

申请号：DE3804621

申请日：1988-02-13

Applicant: HOECHST AG

Inventor： HEISE HARTMUT DR ,  HINTZMANN MANFRED DR

IPC: B01J23/755 ,  C07B61/00 ,  C07C231/02 ,  C07C233/25 ,  C07C233/43

Abstract: Process for the preparation of 4-acylamino-2-aminoalkoxybenzenes of the formula (1) … … in which R denotes a C1-C6-alkyl or C1-C4-alkoxy-C1-C4-alkylene group and R' denotes a methyl or ethyl group, by pumping a solution or suspension of a 2,4-dinitroalkoxybenzene of the formula (2) … … in which R has the said meaning, in a butyl acetate into a suspension of a nickel catalyst on a kieselguhr support in butyl acetate, which is initially introduced into an autoclave and stirred, at a hydrogen pressure of about 5 to 50 bar and a temperature of about 60 to about 120 DEG C at a rate which corresponds to the rate of hydrogenation of the 2,4-dinitroalkoxybenzene to the 2,4-diaminoalkoxybenzene, removing water from the reduction solution by azeotropic distillation after the hydrogenation and acylating the resultant 2,4-diaminoalkoxybenzene with about 0.90 to about 0.99 mol of the anhydride of an alkyl- monocarboxylic acid of 2 to 3 C atoms, relative to 1 mol of 2,4-diaminoalkoxybenzene, at about -5 to about +15 DEG C.

公开(公告)号：CH637103A5

公开(公告)日：1983-07-15

申请号：CH1466277

申请日：1977-11-30

Applicant: HOECHST AG

Inventor： BERTHOLD RUEDIGER DR ,  MEES BERNHARD DR ,  HEISE HARTMUT DR

IPC: C07C69/67 ,  B01J31/00 ,  C07B61/00 ,  C07C45/00 ,  C07C45/72 ,  C07C45/75 ,  C07C49/603 ,  C07C67/00 ,  C07C69/757 ,  C07C69/716 ,  C07C69/738

公开(公告)号：CH632485A5

公开(公告)日：1982-10-15

申请号：CH547278

申请日：1978-05-19

Applicant: HOECHST AG

Inventor： SCHNEIDER MAX DR ,  SCHMITT LOTHAR ,  HEISE HARTMUT DR

IPC: C07C233/15 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C103/375 ,  C07C76/02

公开(公告)号：CH629193A5

公开(公告)日：1982-04-15

申请号：CH352677

申请日：1977-03-21

Applicant: HOECHST AG

Inventor： HEISE HARTMUT DR ,  LEIBMANN BERND DR ,  MOERLER DIETER DR ,  RITTER EBERHARD DR ,  SAHM WILFRIED DR

IPC: C07D235/26

公开(公告)号：DE2609835A1

公开(公告)日：1977-09-22

申请号：DE2609835

申请日：1976-03-10

Applicant: HOECHST AG

Inventor： KUEMMERLE KURT DR ,  HEISE HARTMUT DR ,  HILLE ERNST DR

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/40 ,  B01J23/74 ,  B01J31/00 ,  B01J31/02 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/16 ,  C07C235/24 ,  C07C103/34

Abstract: The liquid-phase catalytic hydrogenation of N-acetoacetyl arylamides to yield 3-hydroxybutyric acid arylamides proceeds much faster when amines, phosphines or trialkylphosphates are added. Thus, even with lower hydrogen pressures and at lower temperatures with a lower catalyst concentration, shorter reaction times are sufficient.