中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

35 records (took 0.021 seconds)

    NOVEL O-PROPYLOXIMES
    12.
    发明专利
    NOVEL O-PROPYLOXIMES 未知

    公开(公告)号：ZA777586B

    公开(公告)日：1978-11-29

    申请号：ZA777586

    申请日：1977-12-21

    Applicant: HOECHST AG

    Inventor： CARTHEUSER C ,  THORWART W ,  GEBERT U ,  POPENDIKER K ,  KOMAREK J ,  GREVE H

    IPC: C07D295/08 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P25/20 ,  C07D209/14 ,  C07D211/22 ,  C07D213/53 ,  C07D213/80 ,  C07D231/16 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D295/088 ,  C07D303/12 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D333/22 ,  C07D473/12 ,  A61K31/51 ,  C07D295/18 ,  C07C131/00

    Abstract: Compounds of general formula (I) wherein R1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl; (b) alkyl, alkenyl each having up to 6 carbon atoms and their phenyl substituted derivatives; (c) at most binuclear unsubstituted aryl, at most binuclear aryl substituted by from 1 to 3 substituents selected from the group consisting of alkyl and alkoxy each having up to 6 carbon atoms, benzloxy, haloalkyl having up to 2 carbon atoms, halogen, cyano and nitro; amino, carboxyl and hydroxy; amino, carboxyl and hydroxy each being substituted by alkyl having at most 2 carbon atoms, methylenedioxy groups and O- -hydroximinom ethyl groups; (d) at most bicyclic unsubstituted heteroaromatic group having 1 to 4 heteroatoms selected from the group consisting of nitrogen, one sulphur and one oxygen in the ring system and such a heteroaromatic group being substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy each having up to 2 carbon atoms, phenylalkyl having up to 3 carbon atoms in the alkyl moiety, halogen, methylamino and dimethylamino; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, cycloalkyl having up to 6 carbon atoms and phenyl; and R1 and R2, together with the carbon atom to which they are attached, form a radical selected from the group consisting of fluorene-9-ylidene and a cycloaliphatic group having up to 10 carbon atoms and such a cycloaliphatic group containing a hydrocarbon bridging group; R3 represents a member selected from the group consisting of hydrogen hydroxy and acyloxy; R4 represents a member selected from the group consisting of hydrogen alkyl having up to 3 carbon atoms and phenyl; R5 represents a member selected from the group consisting of halogen, alkoxy having up to 2 carbon atoms and hydroxy; and X represents a member selected from the group consisting of nitrogen and methine and physiologically acceptable acid addition salts thereof; a pharmaceutical composition containing said compounds.

    13.
    发明专利
    未知

    公开(公告)号：SE7712630L

    公开(公告)日：1978-05-10

    申请号：SE7712630

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C83/00 ,  C07C83/04 ,  C07C149/00 ,  C07C93/02 ,  C07D233/54 ,  C07D235/04 ,  C07D249/02

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

    XANTHINE DERIVATIVES
    14.
    发明专利
    XANTHINE DERIVATIVES 未知

    公开(公告)号：ZA743760B

    公开(公告)日：1975-06-25

    申请号：ZA743760

    申请日：1974-06-12

    Applicant: HOECHST AG

    Inventor： JAYME M ,  MOHLER W ,  KOMAREK J

    IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D57/40

    Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

    17.
    发明专利
    未知

    公开(公告)号：NO742121L

    公开(公告)日：1975-01-13

    申请号：NO742121

    申请日：1974-06-11

    Applicant: HOECHST AG

    Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

    IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D

    Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

    18.
    发明专利
    未知

    公开(公告)号：FI181974A

    公开(公告)日：1974-12-17

    申请号：FI181974

    申请日：1974-06-14

    Applicant: HOECHST AG

    Inventor： MOHLER W ,  JAYME M ,  KOMAREK J

    IPC: A61K31/52 ,  A61K31/522 ,  A61P7/02 ,  A61P9/08 ,  C07D473/06 ,  C07D

    Abstract: Compounds of general formula (I) wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in ( omega -1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R2 and the other one of groups R1 and R3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R1 or R3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

    19.
    发明专利
    未知

    公开(公告)号：SE441265B

    公开(公告)日：1985-09-23

    申请号：SE7712630

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CHARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C83/04 ,  C07C93/02 ,  C07C149/00 ,  C07D233/54 ,  C07D235/04 ,  C07D249/02

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

Patent Agency Ranking