公开(公告)号：ES2062214T3

公开(公告)日：1994-12-16

申请号：ES90113712

申请日：1990-07-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：CZ278318B6

公开(公告)日：1993-11-17

申请号：CS431890

申请日：1990-09-05

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  LANG HANS-JOCHEN DR ,  LINZ WOLFGANG DR ,  SCHOLKENS BERNWARD PROF DR ,  SCHOLZ WOLFGANG DR

IPC: C07C279/22 ,  A61K31/155 ,  A61K31/18 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/455 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C277/00 ,  C07C279/10 ,  C07C311/15 ,  C07C311/47 ,  C07C317/42 ,  C07C317/44 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65 ,  C07C323/67 ,  C07D209/08 ,  C07D211/28 ,  C07D295/14 ,  C07D295/155 ,  C07D295/195 ,  C07D295/22 ,  C07D295/26

Abstract: Benzoylguanidines of the formula I (* CHEMICAL STRUCTURE *) (I) where R(1) or R(2) is equal to R(6)-S(O)n- or R(7)R(8)N-O2S- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)-S(O)n or R(7)R(8)N- and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(7) and R(8) are equal to alkyl or phenylalkyl or phenyl, and in which R(7) and R(8) may also together be a C4-C7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(4) are together an alkylene chain, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.

公开(公告)号：BR9202327A

公开(公告)日：1993-01-19

申请号：BR9202327

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00 ,  C07D487/02 ,  A61K31/395

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：CZ9201906A3

公开(公告)日：1993-01-13

申请号：CS190692

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D213/30 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14

公开(公告)号：CZ9201879A3

公开(公告)日：1993-01-13

申请号：CS187992

申请日：1992-06-18

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04

公开(公告)号：CS9103471A3

公开(公告)日：1992-06-17

申请号：CS347191

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  SCHOLKENS BERNWARD PROF DR ,  URBACH HANSJORG DR

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

CPC classification number: A61K31/415 ,  A61K31/41

公开(公告)号：CS368890A3

公开(公告)日：1992-02-19

申请号：CS368890

申请日：1990-07-24

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMES WERNER DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：DE3932817A1

公开(公告)日：1991-04-11

申请号：DE3932817

申请日：1989-09-30

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJOERG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER DR DR

IPC: C07D233/54 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07K5/065 ,  C07K5/078

Abstract: Peptide polyhydroxyalkylamides of formula (I) and their salts are new; where A = R1R6N-CHR5-CO-, R1R7CH-CHR5-CO- or R1O-CHR5-CO-; R1 = R'1 or R'1W; R'1 = (a) 3-8C cycloalkyl, CONH2, OCH2COOH, NH2, etc. (b) H, OH or 1-4C alkoxy, (c) 1-18C alkyl, quanidino, phenyl(1-4C)alkoxy, etc. (d) 6-14C aryl, (6-14C)aryl(1-4C)alkyl, etc. (e) Het or Het(1-4C)alkyl, where Het is an opt. benzo-fused 5- to 7-membered heterocyclic ring contg. 1 or 2 of N, O, S, No, etc. (f) NR8R9; Het or Het(1-4C)alkyl, or NR8R9 is a mono- or bicyclic 5- to 12-membered ring system opt. contg. 1 or 2 more N atoms, an S atom or an O atom, opt. substd. by 1-4C alkyl; W = CO, CS, OSO, SO2, SO, NHSO2, NHCO, CHOH or NOH; n = 2-10.

公开(公告)号：MY115229A

公开(公告)日：2003-04-30

申请号：MYPI9605219

申请日：1996-12-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  LINZ WOLFGANG DR ,  GOGELEIN HEINZ DR ,  KLAUS ERIK DR ,  CRAUSE PETER DR

IPC: C07D311/58 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12

Abstract: CHROMANYSULFONYL(THIO)UREAS OF THE FORMULA I ARE USEFUL PHARMACEUTICALS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS AND FOR THE PREVENTION OF SUDDEN HEART DEATH DUE TO ARRHYTHMIA. THEY CAN BE USED AS ANTIARRHYTHMICS AND ARE SUITABLE FOR THE PREVENTION OF SUDDEN HEART DEATH, FOR THE TREATMENT OF CARDIAC INSUFFICIENCY AND ALSO HEART FAILURE AS A RESULT OF THE EFFECTS OF SHOCK.

公开(公告)号：AT165351T

公开(公告)日：1998-05-15

申请号：AT91122406

申请日：1992-01-01

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.