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    14.
    发明专利
    未知

    公开(公告)号：AT122659T

    公开(公告)日：1995-06-15

    申请号：AT93102220

    申请日：1993-02-12

    Applicant: HOECHST AG

    Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  WETTLAUFER DAVID DR ,  KLAUS ERIK DR

    IPC: A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61P9/00 ,  A61P21/00 ,  C07D213/64 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D213/89 ,  C07D401/12 ,  A61K31/455 ,  C07D213/82 ,  A61K31/495 ,  A61K31/47

    Abstract: Arylcarbonylaminoalkyl-dihydro-oxo-pyridines of Formula I are disclosed wherein aryl is an aromatic or heteroaromatic system, n is zero through 5; R and R(1), are hydrogen, or loweralkyl; W is hydrogen, (hetero)-(aryl)-loweralkyl; Z is hydrogen, CH2OR(2), CHO, (CO)OR(2), (CO)NR(2)2. Processes for the preparation of compound I are also disclosed. Compounds I are suitable for the treatment of disorders of the cardiovascular system, for example of hypertension, of cardiac insufficiency or of disturbances of blood flow in the coronary systems such as, for example, angina. Disturbances of cerebral and peripheral blood flow are likewise influenced beneficially. Furthermore, compounds I are able to influence smooth-muscle organs such as uterus, bronchi, intestines and biliary system, the urinary tract (ureter, bladder and urethra) in the sense of spasmolysis. They are therefore also suitable for the treatment of diseases associated with spasms of these organs, for example for the treatment of premature labor in pregnancy, of ureteral or biliary colic, of obstructive airway diseases such as asthma, of disturbances of intestinal motility such as, for example, of irritable colon or of bladder incontinence. Additionally, compounds of formula I can serve as anti-convulsants in the treatment of epilepsy and as hair growth inducers in the treatment of baldness.

    16.
    发明专利
    未知

    公开(公告)号：DE3881714D1

    公开(公告)日：1993-07-22

    申请号：DE3881714

    申请日：1988-01-30

    Applicant: HOECHST AG

    Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  LANG HANS-JOCHEN DR ,  MANIA DIETER DR ,  SCHOELKENS BERNWARD DR ,  KLAUS ERIK DR

    IPC: A61K31/40 ,  A61K31/41 ,  A61K31/535 ,  A61K31/54 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

    Abstract: 4-Heterocyclyl-3-hydroxy-benzopyran derivs. of formula (I) in which the C3 and C4 substits. are trans to each other are new; where R1 = CN, NO2; 1-6C alkyl-5(O)n or Ar5(O)n; n = 1 or 2; Ar = aromatic or heterocyclic system opt. substd. by 1-3 of 1-2C alkyl or alkoxy, halo, CF3, CN, NO2, 1-2C alkylcarbonyl or 1-2C alkyl-S (O)p; p = 1 or 2; R2 = H, OH, 1-2C alkyl or alkoxy, halo or NR5R6; R5 and R6 = H, 1-2C alkyl or 102C alkylcarbonyl; R3 and R4 = 1 -4C alkyl; the meanings for R1 and R2 may also be interchanged; X = (CH2)m substs. by at least 1 and a max. of (2m-1) 1-2C alkyl, and opt. interrupted by O, NR, or 5; R7 = H or 1-4C alkyl; m = 2-4.

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