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    Benzenesulfonyl-ureas and process for their manufacture
    11.
    发明授权
    Benzenesulfonyl-ureas and process for their manufacture 失效
    苯并呋喃及其制备方法

    公开(公告)号：US3751418A

    公开(公告)日：1973-08-07

    申请号：US3751418D

    申请日：1971-06-03

    Applicant: HOECHST AG

    Inventor： WEYER R ,  AUMULLER W ,  HEERDT R ,  WEBER H ,  SCHWEITZER R

    IPC: C07D215/48 ,  C07D33/56

    CPC classification number: C07D215/48 ,  Y10S514/866

    Abstract: HYPOGLYCEMICALLY ACTIVE BENZENESULFONYL-UREAS OF THE FORMULA

    (X-QUINOLIN-8-YL)-CO-NH-Y-(2-Z-1,4-PHENYLENE)-SO2-NH-CO-

    NH-R

    WHEREIN X IS HYDROGEN, CHLORINE, BROMINE, METHOXY OR METHYL, Y IS -CH(CH3)-CH2-, -CH2-CH(CH3)OR -CH2CH2-, R IS ALKYL OF 3 TO 6 CARBON ATOMS, CYCLOALKYL OF 5 TO 8 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY 1 OR 2 ALKYL OF UP TO 3 CARBON ATOMS OR BY CHLORINE, CYCLOALKENYL OF 5 TO 8 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY 1 TO 2 ALKYL OF UP TO 3 CARBON ATOMS, BICYCLOALKYL OR BICYCLOALKENYL OF 7 OR 8 CARBON ATOMS, NORTRICYCLYL, SPIRO(2,4)-HEPTYL, Z IS HYDROGEN OR A HYDROCARBON RADICAL OF 1 OR 2 CARBON ATOMS WHICH FORMS WITH Y A 5- OR 6-MEMBERED RING, OR THE SALTS THEREOF AS WELL AS A PROCESS FOR THEIR MANUFACTURE.

    Benzenesulfonamidopyrimidines
    12.
    发明授权
    Benzenesulfonamidopyrimidines 失效
    苯并呋喃二恶嗪

    公开(公告)号：US3816424A

    公开(公告)日：1974-06-11

    申请号：US22653072

    申请日：1972-02-15

    Applicant: HOECHST AG

    Inventor： WEYER R ,  WEBER H ,  HUBNER M ,  AUMULLER W ,  SCHWEITZER R

    IPC: A61K31/18 ,  A61K31/47 ,  A61K31/505 ,  C07D215/14 ,  C07D215/48 ,  C07D239/42 ,  C07D239/69 ,  C07D401/12 ,  C07D57/00

    CPC classification number: C07D239/69 ,  C07D215/48 ,  Y10S514/866

    Abstract: NEW SULFONAMIDOPYRIMIDINES WITH HYPOGLYCEMIC PROPERTIES HAVING THE FORMULA

    1-((X-QUINOL-8-YL)-CO-NH-Y-),2-R,4-((4-R",5-R''-PYRIMIDIN-

    2-YL)-NH-SO2-)BENZENE

    IN WHICH X REPRESENTS HYDROGEN, CHLORINE, BROMINE, METHYL, METHOXY Y REPRESENTS -CH(CH3)-CH2-, OR, PREFERABLY,

    -CH2-CH2-

    R REPRESENTS HYDROGEN OR, TOGETHER WITH Y, A BRIDGE OF 3 OR 4 CARBON ATOMS, R'' REPRESENTS ALKYL, CYCLOALKYL, CYCLOALKYLALKYL, ARYL, ARALKYL, ALKOXY, CYCLOALKOXY, ALKOXYALKYL, ALKOXYALKOXY, ALKYLMERCAPTO, ALKYLMERCAPTOALKYL, THE ALKLY CONTAINING, IN ANY CASE FROM 1 TO 4 CARBON ATOMS AND THE CYCLOALKYL, IN ANY CASE, 5 TO 8 CARBON ATOMS, R" REPRESENTS HYDROGEN, LOWER ALKYL, R" AND R'' TOGETHER BEING ABLE TO FORM A RING OF FROM 3 TO 5 METHYL GROUPS, AND PHYSIOLOGICALLY TOLERABLE SALTS THEREOF AND PROCESSES FOR THEIR PREPARATION.

    Benzenesulfonyl ureas and process for their manufacture
    13.
    发明授权
    Benzenesulfonyl ureas and process for their manufacture 失效
    苯并呋喃的制备及其制备方法

    公开(公告)号：US3850950A

    公开(公告)日：1974-11-26

    申请号：US36341473

    申请日：1973-05-24

    Applicant: HOECHST AG

    Inventor： HITZEL V ,  HUBNER M ,  AUMULLER W ,  WEYER R

    IPC: C07D263/56 ,  C07D85/48

    CPC classification number: C07D263/56 ,  Y10S514/866

    Abstract: 1. SULFONYL UREAS OF THE FORMULA

    2-R1,5-X,7-(R-NH-CO-NH-SO2-(1,4-PHENYLENE)-Y-NH-CO-)-

    BENZOXAZOLE

    IN WHICH R1 IS HYDROGEN, METHYL, ETHYL, PHENYL, X IS HYDROGEN, CHLORINE, BROMINE OR METHYL, Y IS -CH(CH3)-CH2-, -CH2-CH(CH3)- OR, PREFERABLY, -CH2-CH2-, R IS ALKYL HAVING FROM 3 TO 6 CARBON ATOMS, CYCLOALKYL, ALKYLCYCLOALKYL, CYCLOALKYLALKYL, CYCLOALKENYL, ALKYLCYCLOALKENYL EACH HAVING FROM 5 TO 9 CARBON ATOMS, CYCLOHEXENYLMETHYL, CHLOROCYCLOHEXYL, BICYCLOHEPTENYLMETHYL, BICYCLOHEPTYLMETHYL, BICYCLOHEPTENYL, BICYCLOHEPTYL, NORTRICYCLYL, ADAMANTYL AND PHENYLALKYL HAVING FROM 1 TO 2 ALKYL CARBON ATOMS AND THE PHYSILOGICALLY TOLERABLE SALTS THEREOF.

    Benzenesulfonyl ureas
    15.
    发明授权
    Benzenesulfonyl ureas 失效
    苯并呋喃酸

    公开(公告)号：US3812185A

    公开(公告)日：1974-05-21

    申请号：US4116170

    申请日：1970-05-25

    Applicant: HOECHST AG

    Inventor： WEBER H ,  WEYER R ,  AUMUELLER W ,  MUTH K

    IPC: C07C311/59 ,  C07D333/38 ,  C07D333/70 ,  C07C127/00

    CPC classification number: C07D333/38 ,  C07C311/59 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/50 ,  C07C2603/66 ,  C07D333/70 ,  Y10S514/866

    Abstract: BENZENESULFONYL-UREAS HAVING HYPOGLYCEMIC ACTIVITIES CORRESPONDING TO THE FORMULA

    1-(R1-NH-CO-NH-SO2-),4-(X-CO-NH-Y-)BENZENE

    WHEREIN R1 IS (A) NOCRARAN-7-YL, BICYCLO- 3,1,0!-HEXYL, BICYCLO- 5, 1,0!-OCTYL, OR BICYCLO- 6,1,0!-NONYL; (B) 4,7-ENDOMETHYLENE - PERHYDROINDAN-5-YL; 4,7ENDOMETHYLENE-6-CHLORO-PERHYROINDAN-5-YL; 4,7ENDOMETHYLENE-PERHYDROINDAN - 2 YL; 2,6-ENDOMETHYLENECYCLOHEPTYL; 2,5-ENDOCYCLOBUTYLENE-1,2CYCLOHEXYL; EXO-TRICYCLO-(3,2,1,02,4)-OCTANYL; (C) SPIRO-(2-CYCLOPROPANE) - CYCLOPETYL; SPIRO-(2CYCLOBUTANE)-CYCLOPENTYL; SPIRO-(2-CYCLOPETANE)CYCLOPENTYL; SPIRO-(2-CYLOHEXANE)-CYCLOPENTYL; OR SPIRO-(5,5)-UNDECYL-3; X IS

    A,A1-PHENYL OR 3-B,5-A1-THIEN-2-YL

    IN WHICH A STANDS FOR HYDROGEN, HALOGEN, RIFLUOROMETHYL, PHENOXY, LOWER ALKYL OR LOWER ALKOXY BOTH HAVING 1-4 CARBON ATOMS, A1 STANDS FOR HYDROGEN, HALOGEN OR LOWER ALKYL OF 1-4 CARBON ATOMS AND B STANDS FOR HYDROGEN OR LOWER ALKOXY HOF 1-4 CARBON ATOMS Y IS A HYDROCARBON CHAIN OF 1-3 CARBON ATOMS OR A PHYSIOLOGICALLY TOLERABLE SALT THEREOF.

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