Continuous, capacitance-based monitoring of liquid flows in a microfluidic device

    公开(公告)号:GB2558839B

    公开(公告)日:2021-04-14

    申请号:GB201807075

    申请日:2016-10-13

    Applicant: IBM

    Abstract: A microfluidic chip comprising a microchannel fillable with a liquid, the microchannel comprises a pair of electrodes, and a liquid flow path defined between the electrodes, wherein each of the electrodes extends along the flow path and parallel to a direction of a liquid filling the microchannel, in operation, and an electrical circuitry connected to each of the electrodes and configured to continuously measure, via the electrodes, a capacitance of the electrodes being wet by a liquid continuously filling the flow path, as a function of time, in operation.

    Continuous, capacitance-based monitoring of liquid flows in a microfluidic device

    公开(公告)号:GB2558839A

    公开(公告)日:2018-07-18

    申请号:GB201807075

    申请日:2016-10-13

    Applicant: IBM

    Abstract: A microfluidic chip (10) comprising a microchannel (11,11a) fillable with a liquid (5), the microchannel (11,11a) comprises a pair of electrodes (21,22,21a,22a), and a liquid flow path (12) defined between the electrodes (21,22,21a,22a), wherein each of the electrodes (21,22,21a,22a) extends along the flow path (12) and parallel to a direction of a liquid (5) filling the microchannel (11,11a), in operation, and an electrical circuitry connected to each of the electrodes (21,22,21a,22a) and configured to continuously measure, via the electrodes (21,22,21a,22a), a capacitance of the electrodes (21,22,21a,22a) being wet by a liquid (5) continuously filling the flow path (12), as a function of time, in operation.

    Authentication of packaged products

    公开(公告)号:GB2589760A

    公开(公告)日:2021-06-09

    申请号:GB202020421

    申请日:2019-04-30

    Applicant: IBM

    Abstract: Methods are provided for producing an authenticated packaged product. The method includes providing on the product a security code encoding security data for the product, packing the product in packaging, and providing a tag carrying encrypted product data on the packaging. The product data comprises the security data for the product. The method further comprises storing a decryption key for the encrypted product data at a network server, and providing on the packaging access data for accessing the decryption key at the network server. Corresponding methods and systems are provided for verifying authenticity of such an authenticated packaged product.

    Customizable microfluidic device with programmable microfluidic nodes

    公开(公告)号:GB2578977B

    公开(公告)日:2021-04-21

    申请号:GB202000287

    申请日:2018-06-20

    Applicant: IBM

    Abstract: The invention is directed to a microfluidic device. The device includes an input microchannel, a set of m distribution microchannels, a set of m microfluidic modules and a set of m nodes. The m microfluidic modules (m≥2) are in fluidic communication with the m distribution microchannels, respectively. The one or more nodes of the set of m nodes branch from the input microchannel, and further branch to a respective one of the set of m distribution microchannels. In addition, a subset, but not all, of the nodes are altered. The nodes of the set of m nodes have different liquid pinning strengths. As a result, the extent in which a liquid passes through one or more of the m microfluidic modules varies based on the different liquid pinning strengths, in operation. Additional sets of nodes may be provided to allow liquid to pass through ordered pairs of modules.

    Microfluidic device with longitudinal and transversal liquid barriers for transversal flow mixing

    公开(公告)号:GB2555949B

    公开(公告)日:2020-12-16

    申请号:GB201716508

    申请日:2015-06-15

    Applicant: IBM

    Abstract: A microfluidic device including one or more microchannels. Each microchannel comprising: a microchannel portion with a longitudinal liquid barrier that defines first and second regions. The device includes one or more first liquid passages at the level of the longitudinal barrier. A liquid inlet allows liquid to enter the first region and a liquid outlet allows liquid to leave the microchannel portion. A transverse liquid barrier between the microchannel portion and the liquid outlet holds liquid in the first region. The device includes one or more second liquid passages at the level of the transverse liquid barrier. A liquid pump displaces liquid through a microchannel portion. The first liquid passages allow excess liquid in the first region to flow into the second region, transversally to the longitudinal barrier. The second liquid passages allow excess liquid in the longitudinal portion to be discharged via the liquid outlet.

    Microfluidic chip with bead integration system

    公开(公告)号:GB2570596A

    公开(公告)日:2019-07-31

    申请号:GB201905496

    申请日:2017-10-19

    Applicant: IBM

    Abstract: The present invention is notably directed to a microfluidic chip. The chip comprises a main microfluidic channel, on one side of the chip, and a bead integration system. The bead integration system is arranged on said one side of the chip. It comprises an auxiliary microfluidic channel transverse to and in fluidic communication with the main microfluidic channel, so as to form an intersection therewith. The intersection is delimited by structural elements arranged in the main microfluidic channel. The structural elements are configured to retain, at said intersection, beads flowed in a bead suspension liquid advancing in said auxiliary microfluidic channel and passing the intersection. In addition, such structural elements are configured to let liquid advancing in the main microfluidic channel pass the intersection through the structural elements. The invention is further directed to related devices and methods.

    Operation of diagnostic devices involving microchannels and electrodes

    公开(公告)号:GB2547753A

    公开(公告)日:2017-08-30

    申请号:GB201621803

    申请日:2016-12-21

    Applicant: IBM

    Abstract: An assembly for interfacing with a microfluidic chip 238 having at least one microscopic channel with at least one embedded electrode configured to receive a liquid sample for analysis and at least one chip contact coupled to the electrode, the assembly comprising a chip carrier 240, an electronics module 110, an optical module 118 and a mechanical module. The chip carrier includes a base and a cover which define a cavity 236 for receiving the chip, and at least one chip carrier contact 234 to engage with the chip contact. The electronics module comprises at least one electronic module contact 248 which engage with the chip carrier contacts and a signal generator which applies at least one electrokinetic signal to the embedded electrode(s) of the chip via the electronic module contacts. The optical module includes an excitation radiation source and an emission radiation detector. The mechanical module is controlled by the electronics module and comprises a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom. The embedded electrodes are ideally dielectrophoresis electrodes. A method of carrying out a test on a microfluidic chip employing impedance changes is also disclosed.

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