Microfluidic chip with bead integration system

    公开(公告)号:GB2570596B

    公开(公告)日:2020-12-16

    申请号:GB201905496

    申请日:2017-10-19

    Applicant: IBM

    Abstract: The present invention is notably directed to a microfluidic chip. The chip comprises a main microfluidic channel, on one side of the chip, and a bead integration system. The bead integration system is arranged on said one side of the chip. It comprises an auxiliary microfluidic channel transverse to and in fluidic communication with the main microfluidic channel, so as to form an intersection therewith. The intersection is delimited by structural elements arranged in the main microfluidic channel. The structural elements are configured to retain, at said intersection, beads flowed in a bead suspension liquid advancing in said auxiliary microfluidic channel and passing the intersection. In addition, such structural elements are configured to let liquid advancing in the main microfluidic channel pass the intersection through the structural elements. The invention is further directed to related devices and methods.

    Microfluidic chip with bead integration system

    公开(公告)号:GB2570596A

    公开(公告)日:2019-07-31

    申请号:GB201905496

    申请日:2017-10-19

    Applicant: IBM

    Abstract: The present invention is notably directed to a microfluidic chip. The chip comprises a main microfluidic channel, on one side of the chip, and a bead integration system. The bead integration system is arranged on said one side of the chip. It comprises an auxiliary microfluidic channel transverse to and in fluidic communication with the main microfluidic channel, so as to form an intersection therewith. The intersection is delimited by structural elements arranged in the main microfluidic channel. The structural elements are configured to retain, at said intersection, beads flowed in a bead suspension liquid advancing in said auxiliary microfluidic channel and passing the intersection. In addition, such structural elements are configured to let liquid advancing in the main microfluidic channel pass the intersection through the structural elements. The invention is further directed to related devices and methods.

    Operation of diagnostic devices involving microchannels and electrodes

    公开(公告)号:GB2547753A

    公开(公告)日:2017-08-30

    申请号:GB201621803

    申请日:2016-12-21

    Applicant: IBM

    Abstract: An assembly for interfacing with a microfluidic chip 238 having at least one microscopic channel with at least one embedded electrode configured to receive a liquid sample for analysis and at least one chip contact coupled to the electrode, the assembly comprising a chip carrier 240, an electronics module 110, an optical module 118 and a mechanical module. The chip carrier includes a base and a cover which define a cavity 236 for receiving the chip, and at least one chip carrier contact 234 to engage with the chip contact. The electronics module comprises at least one electronic module contact 248 which engage with the chip carrier contacts and a signal generator which applies at least one electrokinetic signal to the embedded electrode(s) of the chip via the electronic module contacts. The optical module includes an excitation radiation source and an emission radiation detector. The mechanical module is controlled by the electronics module and comprises a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom. The embedded electrodes are ideally dielectrophoresis electrodes. A method of carrying out a test on a microfluidic chip employing impedance changes is also disclosed.

    Microfluidic device with laterally insertable electrodes

    公开(公告)号:GB2581291A

    公开(公告)日:2020-08-12

    申请号:GB202006022

    申请日:2018-09-13

    Applicant: IBM

    Abstract: The invention is notably directed to a microfluidic device. The device comprises a substrate with a microchannel formed as a groove on a main surface of the substrate. The device further comprises one or more conduits extending parallel to the main surface of the substrate, and from a lateral surface of the substrate up to a lateral wall of the microchannel. The one or more conduits are configured so as to allow insertion of one or more electrodes therein, respectively, and such that an end of each of the one or more electrodes can reach into the microchannel. The invention is further directed to related sets of components, which include the above microfluidic device, as well as a housing, with electronics, and, possibly, a porous support (e.g., a membrane) and a cap. Biosensing applications are notably contemplated. The invention is further directed to methods of operating a microfluidic device.

    Microfluidic device with anti-wetting, venting areas

    公开(公告)号:GB2553713A

    公开(公告)日:2018-03-14

    申请号:GB201716704

    申请日:2016-03-16

    Applicant: IBM

    Abstract: Amicrofluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti- wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.

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