公开(公告)号：WO1997009965A1

公开(公告)日：1997-03-20

申请号：PCT/US1996011387

申请日：1996-06-25

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  TSENG, Susan, Y. ,  CHUANG, Jui-Chang ,  WOLF, Philip, F. ,  HELIOFF, Michael, W. ,  KRUMMEL, H., Karl ,  DAVIS, Mary, R.

IPC: A61K09/14

CPC classification number: A61K8/042 ,  A61K8/0241 ,  A61K8/365 ,  A61K8/368 ,  A61K8/8176 ,  A61K8/8182 ,  A61K31/19 ,  A61K31/194 ,  A61K31/20 ,  A61K31/60 ,  A61K2800/75 ,  A61Q5/00 ,  A61Q5/08 ,  A61Q19/00 ,  A61Q19/02

Abstract: This invention relates to an acidic non-irritating lotion, cream or ointment for rejuvenating skin and hair which comprises a micronized, homogenized hydrogen of a cross-linked N-vinyl lactam polymer and an organic rejuvenating agent selected from the group consisting of pyruvic acid, a mono- or poly- carboxylated C1 to C20 hydrocarbon optionally substituted with from 1 to 3 hydroxy groups and ammonium and alkali metal salts of said acids and mixtures thereof including mixtures of the acids and/or said salts. The invention also relates to a cross-linked N-vinyl lactam polymer in the form of a stable, homogenized flowable hydrogel having microparticles which can be passed through a screen of between about 40 and about 350 mesh size and to the process for the preparation of the homogenized gel and to its use as a hair and skin conditioner or as a carrier for a cosmetically or pharmaceutically active substance.

Abstract translation: 本发明涉及一种酸性非刺激性洗剂，用于使皮肤和毛发恢复嫩肤的霜剂或软膏，其包含交联的N-乙烯基内酰胺聚合物的微粉化均化氢和选自丙酮酸， 任选被1至3个羟基取代的单羧基化或多羧基化的C 1至C 20烃，以及所述酸的铵和碱金属盐及其混合物，包括酸和/或所述盐的混合物。 本发明还涉及一种具有稳定的，均匀的可流动水凝胶形式的交联的N-乙烯基内酰胺聚合物，其具有可以通过约40至约350目尺寸的筛网的微粒，以及制备 均质化凝胶及其用作头发和皮肤调理剂或用作化妆品或药物活性物质的载体。

公开(公告)号：WO1993022380A1

公开(公告)日：1993-11-11

申请号：PCT/US1993004081

申请日：1993-04-30

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  LOGIN, Robert, B. ,  SHIH, Jenn, S. ,  CHUANG, Jui-Chang

IPC: C08L29/02

CPC classification number: C08F226/10 ,  C08F8/00

Abstract: Crosslinkable, functional polymers of vinylpyrrolidone and an aminoalkyl acrylamide, or aminoalkene, or hydroxyalkene, are made herein, which can be crosslinked to provide aqueous gels for use in many pharmaceutical applications.

Abstract translation: 乙烯基吡咯烷酮和氨基烷基丙烯酰胺或氨基烯烃或羟基烯烃的可交联官能聚合物在本文中制备，其可以交联以提供用于许多药物应用的含水凝胶。

公开(公告)号：WO1993006165A1

公开(公告)日：1993-04-01

申请号：PCT/US1992006298

申请日：1992-07-31

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  PLOCHOCKA, Krystyna ,  CHUANG, Jui-Chang ,  LOGIN, Robert, B.

IPC: C08K03/30

CPC classification number: C08K5/005 ,  C08K3/30 ,  C08K5/175 ,  C08L35/08 ,  A61K6/0026

Abstract: What is provided herein is a stabilized aqueous solution of a C1-C5 alkyl vinyl ether and maleic acid copolymer which includes about 100 to 1,000 ppm of (1) an additive mixture of (a) about 30-70 % by weight of ethylenediaminetetraacetic acid EDTA and (b) about 30-70 % by weight of a secondary additive which is an organic antioxidant and/or free radical scavenger selected from t-butylhydroquinone, propyl gallate and N,N-diethylhydroxylamine; or (2) 10-500 ppm of an inorganic reducing agent such as sulfur dioxide and salts derived from sulfur dioxide and alkali metals such as sodium or potassium bisulfite, sodium or potassium metabisulfite, sodium or potassium thiosulfite, or sodium or potassium sulfite, said stabilized solution exhibiting a retention of at least about 85-90 % of its original viscosity after 3 months.

Abstract translation: 本文提供的是稳定的C1-C5烷基乙烯基醚和马来酸共聚物的水溶液，其包括约100至1,000ppm的（1）（a）约30-70重量％的乙二胺四乙酸EDTA的添加剂混合物 和（b）约30-70重量％的二级添加剂，其为选自叔丁基氢醌，没食子酸丙酯和N，N-二乙基羟胺的有机抗氧化剂和/或自由基清除剂; 或（2）10-500ppm的无机还原剂如二氧化硫和二氧化硫和碱金属的盐，如亚硫酸氢钠或焦亚硫酸钠或焦亚硫酸钠，焦亚硫酸钠或焦碳酸钾，硫代硫酸钠或钾，或亚硫酸钠或亚硫酸钠， 稳定的溶液在3个月后保持其原始粘度的至少约85-90％。

公开(公告)号：EP1747240B1

公开(公告)日：2016-07-27

申请号：EP05731177.1

申请日：2005-03-29

Applicant: ISP INVESTMENTS INC.

Inventor： CHUANG, Jui-Chang ,  JACHOWICZ, Janusz ,  WINKLER, Thomas ,  KRAUSS, Allen, J.

IPC: C08F226/06 ,  C08F226/10 ,  C08F220/60 ,  C08F220/34 ,  C08F8/06 ,  C08F2/04 ,  A61K8/81 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q19/00 ,  C08F2/10 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q17/04 ,  A61Q19/08 ,  A61Q19/10

CPC classification number: A61Q19/00 ,  A61K8/8182 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/08 ,  A61Q19/10 ,  C08F2/10 ,  C08F8/06 ,  C08F226/06 ,  C08F2800/20 ,  C08F2810/50 ,  C08F226/10 ,  C08F220/60 ,  C08F2220/603

公开(公告)号：EP0604454A1

公开(公告)日：1994-07-06

申请号：EP92916901.0

申请日：1992-07-31

Applicant: ISP INVESTMENTS INC.

Inventor： PLOCHOCKA, Krystyna ,  CHUANG, Jui-Chang ,  LOGIN, Robert, B.

IPC: A61C13 ,  A61K6 ,  C08K3 ,  C08K5

CPC classification number: C08K5/005 ,  C08K3/30 ,  C08K5/175 ,  C08L35/08 ,  A61K6/0026

Abstract: L'invention se rapporte à une solution aqueuse stabilisée d'éther vinyle alkyle C1-C5 et d'un copolymère d'acide maléique comprenant environ 100 à 1.000 ppm (1) d'un mélange d'additifs de (a) environ 30 à 70 % en poids d'acide éthylènediaminetétraacétique (EDTA) et de (b) environ 30 à 70 % d'un additif secondaire qui est un antioxydant organique et/ou d'un agent épurateur de radicaux libres sélectionné à partir de t-butylhydroquinone, propyle gallate et N,N-diéthylhydroxylamine; ou (2) de 10 à 500 ppm d'un réducteur inorganique tel que du dioxyde de soufre et des sels dérivés du dioxyde de soufre et de métaux alcalins tels que du sodium ou du bisulfite de potassium, du sodium ou du métabisulfite de potassium, du sodium ou du thiosulfite de potassium, ladite solution stabilisée présentant une rétention d'au moins environ 85 à 90 % de sa viscosité d'origine au bout de 3 mois.

公开(公告)号：EP1747240A1

公开(公告)日：2007-01-31

申请号：EP05731177.1

申请日：2005-03-29

Applicant: ISP INVESTMENTS INC.

Inventor： CHUANG, Jui-Chang ,  JACHOWICZ, Janusz ,  WINKLER, Thomas ,  KRAUSS, Allen, J.

IPC: C08F26/08

CPC classification number: A61Q19/00 ,  A61K8/8182 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/08 ,  A61Q19/10 ,  C08F2/10 ,  C08F8/06 ,  C08F226/06 ,  C08F2800/20 ,  C08F2810/50 ,  C08F226/10 ,  C08F220/60 ,  C08F2220/603

Abstract: What is described herein are conditioning/styling tetrapolymers of vinyl caprolactam (VCL), vinylpyrrolidone (VP), dimethylaminopropyl methacrylamide (DMAPMA) and C8-C24 alkyl quaternized dimethylaminopropyl (meth)acrylamide or methacrylic acid quaternized monomers (QDMAPMA), in a defined compositional range. Hair and skin care compositions which include these tetrapolymers exhibit advantageous low tackiness and high humidity resistance.

公开(公告)号：EP1135353A1

公开(公告)日：2001-09-26

申请号：EP99956716.7

申请日：1999-10-28

Applicant: ISP INVESTMENTS INC.

Inventor： BAKEEV, Kirill, N. ,  CHUANG, Jui-Chang ,  DRZEWINSKI, Michael, A. ,  GRAHAM, David, E.

IPC: C07C7/20

CPC classification number: C10L3/06 ,  C09K2208/22 ,  Y10S585/95 ,  Y10T137/0329 ,  Y10T137/0391

Abstract: A composition is provided herein for preventing or retarding the formation of gas hydrates or for reducing the tendency of gas hydrates to agglomerate, during the transport of a fluid comprising water and a hydrocarbon, through a conduit. The composition is a homopolymer of vinyl caprolactam having the low molecular weight in the range of 500 to 2500, or copolymers thereof, in a defined solvent. Such homopolymers and copolymers preferably are made and applied in the defined solvent, which, most preferably, is a glycol ether such as 2-butoxyethanol.

公开(公告)号：EP1037929A1

公开(公告)日：2000-09-27

申请号：EP98958014.7

申请日：1998-11-17

Applicant: ISP INVESTMENTS INC.

Inventor： PLOCHOCKA, Krystyna ,  CHUANG, Jui-Chang ,  SHIH, Jenn, S. ,  MENON, Anil ,  NERELLA, Nadhamuni, G.

IPC: C08F2/06 ,  C08F2/14

CPC classification number: A61K8/062 ,  A61K8/06 ,  A61K8/064 ,  A61K8/8141 ,  A61K9/0014 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44 ,  A61K2800/57 ,  A61Q17/04 ,  A61Q19/00 ,  C08F2/06 ,  C08F226/10 ,  Y10T428/2987 ,  C08F226/04 ,  C08F216/125

Abstract: A non-aqueous, heterogeneous polymerization process comprises heating a reaction mixture of about 5-70 %, preferably 10-30 %, by weight, of a vinyl monomer in an oil as solvent, and a free radical initiator, optionally in the presence of a crosslinking agent and/or a surfactant, wherein the oil solvent is present in an amount sufficient to keep the resultant polymer in a stirrable state throughout the polymerization. The polymer reaction product is capable of forming a uniform emulsion or gel upon addition of water thereto.

公开(公告)号：EP1135353B1

公开(公告)日：2008-12-31

申请号：EP99956716.7

申请日：1999-10-28

Applicant: ISP INVESTMENTS INC.

Inventor： BAKEEV, Kirill, N. ,  CHUANG, Jui-Chang ,  DRZEWINSKI, Michael, A. ,  GRAHAM, David, E.

IPC: C07C7/20 ,  C10L3/06 ,  E21B37/06 ,  C08K5/06 ,  C09K3/00

CPC classification number: C10L3/06 ,  C09K2208/22 ,  Y10S585/95 ,  Y10T137/0329 ,  Y10T137/0391

Abstract: A composition is provided herein for preventing or retarding the formation of gas hydrates or for reducing the tendency of gas hydrates to agglomerate, during the transport of a fluid comprising water and a hydrocarbon, through a conduit. The composition is a homopolymer of vinyl caprolactam having the low molecular weight in the range of 500 to 2500, or copolymers thereof, in a defined solvent. Such homopolymers and copolymers preferably are made and applied in the defined solvent, which, most preferably, is a glycol ether such as 2-butoxyethanol.

公开(公告)号：EP1037929B1

公开(公告)日：2006-07-12

申请号：EP98958014.7

申请日：1998-11-17

Applicant: ISP INVESTMENTS INC.

Inventor： PLOCHOCKA, Krystyna ,  CHUANG, Jui-Chang ,  SHIH, Jenn, S. ,  MENON, Anil ,  NERELLA, Nadhamuni, G.

IPC: C08F2/06 ,  C08F2/14

CPC classification number: A61K8/062 ,  A61K8/06 ,  A61K8/064 ,  A61K8/8141 ,  A61K9/0014 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44 ,  A61K2800/57 ,  A61Q17/04 ,  A61Q19/00 ,  C08F2/06 ,  C08F226/10 ,  Y10T428/2987 ,  C08F226/04 ,  C08F216/125

Abstract: A non-aqueous, heterogeneous polymerization process comprises heating a reaction mixture of about 5-70 %, preferably 10-30 %, by weight, of a vinyl monomer in an oil as solvent, and a free radical initiator, optionally in the presence of a crosslinking agent and/or a surfactant, wherein the oil solvent is present in an amount sufficient to keep the resultant polymer in a stirrable state throughout the polymerization. The polymer reaction product is capable of forming a uniform emulsion or gel upon addition of water thereto.