公开(公告)号：WO1997009965A1

公开(公告)日：1997-03-20

申请号：PCT/US1996011387

申请日：1996-06-25

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  TSENG, Susan, Y. ,  CHUANG, Jui-Chang ,  WOLF, Philip, F. ,  HELIOFF, Michael, W. ,  KRUMMEL, H., Karl ,  DAVIS, Mary, R.

IPC: A61K09/14

CPC classification number: A61K8/042 ,  A61K8/0241 ,  A61K8/365 ,  A61K8/368 ,  A61K8/8176 ,  A61K8/8182 ,  A61K31/19 ,  A61K31/194 ,  A61K31/20 ,  A61K31/60 ,  A61K2800/75 ,  A61Q5/00 ,  A61Q5/08 ,  A61Q19/00 ,  A61Q19/02

Abstract: This invention relates to an acidic non-irritating lotion, cream or ointment for rejuvenating skin and hair which comprises a micronized, homogenized hydrogen of a cross-linked N-vinyl lactam polymer and an organic rejuvenating agent selected from the group consisting of pyruvic acid, a mono- or poly- carboxylated C1 to C20 hydrocarbon optionally substituted with from 1 to 3 hydroxy groups and ammonium and alkali metal salts of said acids and mixtures thereof including mixtures of the acids and/or said salts. The invention also relates to a cross-linked N-vinyl lactam polymer in the form of a stable, homogenized flowable hydrogel having microparticles which can be passed through a screen of between about 40 and about 350 mesh size and to the process for the preparation of the homogenized gel and to its use as a hair and skin conditioner or as a carrier for a cosmetically or pharmaceutically active substance.

Abstract translation: 本发明涉及一种酸性非刺激性洗剂，用于使皮肤和毛发恢复嫩肤的霜剂或软膏，其包含交联的N-乙烯基内酰胺聚合物的微粉化均化氢和选自丙酮酸， 任选被1至3个羟基取代的单羧基化或多羧基化的C 1至C 20烃，以及所述酸的铵和碱金属盐及其混合物，包括酸和/或所述盐的混合物。 本发明还涉及一种具有稳定的，均匀的可流动水凝胶形式的交联的N-乙烯基内酰胺聚合物，其具有可以通过约40至约350目尺寸的筛网的微粒，以及制备 均质化凝胶及其用作头发和皮肤调理剂或用作化妆品或药物活性物质的载体。

公开(公告)号：WO1993014024A1

公开(公告)日：1993-07-22

申请号：PCT/US1992008601

申请日：1992-10-09

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  LOGIN, Robert, B. ,  MERIANOS, John, J. ,  HELIOFF, Michael, W. ,  BIRES, Carmen, D. ,  KOPOLOW, Stephen, L. ,  WALLS, Edward, W., Jr. ,  TAZI, Mohammed ,  KWAK, Yoon, T.

IPC: C01B15/01

CPC classification number: C01B15/01 ,  A61K8/8176 ,  A61K8/8182 ,  A61K8/97 ,  A61Q5/06 ,  A61Q5/08 ,  A61Q5/12

Abstract: A hair care composition comprising: (a) about 3-8 % of a water soluble or dispersible alkylated polyvinylpyrrolidone copolymer powder comprising: (i) about 90-95 % polyvinylpyrrolidone having a K-value of 30-90, and (ii) 5-10 % of an alkylene having 4 carbon atoms; (b) about 50-95 % water; and (c) about 0-60 % alcohol.

Abstract translation: 一种护发组合物，其包含：（a）约3-8％的水溶性或可分散的烷基化聚乙烯吡咯烷酮共聚物粉末，其包含：（i）约90-95％K值为30-90的聚乙烯吡咯烷酮，和（ii）5 -10％的具有4个碳原子的亚烷基; （b）约50-95％的水; 和（c）约0-60％的醇。

公开(公告)号：WO1993002117A1

公开(公告)日：1993-02-04

申请号：PCT/US1992005653

申请日：1992-07-06

Applicant: ISP INVESTMENTS, INC.

Inventor： ISP INVESTMENTS, INC. ,  KWAK, Yoon, T. ,  KOPOLOW, Stephen, L. ,  HELIOFF, Michael, W. ,  TAZI, Mohammed

IPC: C08F225/08

CPC classification number: A61Q5/06 ,  A61K8/8164 ,  A61Q17/04 ,  C08F216/14 ,  C08F222/06

Abstract: What is provided herein is a sunscreen composition consisting essentially of a crosslinked, neutralized terpolymer of maleic anhydride, a C1-C5 alkyl vinyl ether and a C12-C14 alpha-olefin monomer as a thickener; water; an ultraviolet sunscreening agent; and an emulsifier. In the prefered form of the invention, the monomers are present in a molar ratio of about 1:0.90-0.99:0.01-0.10, respectively, and are crosslinked with about 2-8 wt.% of a crosslinking agent based on the total weight of the monomers. Suitably, the crosslinked terpolymer is neutralized to increase water solubility.

Abstract translation: 本文提供的防晒组合物主要由交联的中和的马来酸酐三元共聚物，C 1 -C 5烷基乙烯基醚和作为增稠剂的C 12 -C 14α-烯烃单体组成。 水; 紫外线防晒剂; 和乳化剂。 在本发明的优选形式中，单体分别以约1:0.90-0.99:0.01至0.10的摩尔比存在，并以基于总重量的约2-8重量％的交联剂进行交联 的单体。 适当地，交联的三元共聚物被中和以增加水溶性。

公开(公告)号：WO1992020355A1

公开(公告)日：1992-11-26

申请号：PCT/US1992002542

申请日：1992-04-01

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  MERIANOS, John, J. ,  HELIOFF, Michael, W.

IPC: A61K33/40

CPC classification number: A61Q19/00 ,  A61K8/22 ,  A61K8/8176 ,  A61K33/40 ,  A61K47/58 ,  A61K2800/31 ,  Y10S514/859

Abstract: What is provided herein is a method for treating acne vulgaris with a composition containing a stable, high purity, substantially anhydrous complex of PVP and H2O2 in which the constituents are present respectively in substantially a 1:1 molar ratio and the complex is a free-flowing, fine white powder.

公开(公告)号：WO1991015947A1

公开(公告)日：1991-10-31

申请号：PCT/US1991001868

申请日：1991-03-22

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  KOPOLOW, Stephen, L. ,  BURLANT, William, J. ,  HELIOFF, Michael, W. ,  BIRES, Carmen, D. ,  LOGIN, Robert, B. ,  TAZI, Mohammed ,  NEGRIN, Max ,  DANDREAUX, Gary

IPC: A01J21/00

CPC classification number: B01J13/18 ,  A61K8/11 ,  A61K8/8176 ,  A61K8/891 ,  A61K2800/242 ,  A61K2800/412 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/002 ,  A61Q19/007 ,  A61Q19/008 ,  A61Q19/10

Abstract: What is provided herein is a method for preparing a product which comprises discrete microdroplets of an oil in water stabilized by in situ polymerization of a water-soluble vinyl monomer. The method comprises dispersing the oil in water, optionally with a surfactant, adding the water-soluble vinyl monomer, preferably vinylpyrrolidone, optionally with a comonomer, and polymerizing the monomer or comonomers in situ such that the oil is stabilized in the resulting polymer solution as discrete microdroplets. The product is used in conditioning hair care compositions and hair and skin care compositions, including those containing a water-soluble acryl comonomer.

Abstract translation: 本文提供的是一种制备产物的方法，其包括通过水溶性乙烯基单体的原位聚合稳定的水中的油分散的微滴。 该方法包括将油分散在水中，任选地加入表面活性剂，任选地加入共聚单体加入水溶性乙烯基单体，优选乙烯基吡咯烷酮，并原位聚合单体或共聚单体，使得油在所得聚合物溶液中稳定化为 离散微滴。 该产品用于调理护发组合物和头发和皮肤护理组合物，包括含有水溶性丙烯酸共聚单体的组合物。

公开(公告)号：WO1992007011A1

公开(公告)日：1992-04-30

申请号：PCT/US1991005239

申请日：1991-07-24

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  SHIH, Jenn, S. ,  CHUANG, Jui-chang ,  SMITH, Terry, E. ,  BIRES, Carmen, D. ,  HELIOFF, Michael, W. ,  LOGIN, Robert, B.

IPC: C08F26/06

CPC classification number: A61Q19/00 ,  A61K8/8176 ,  A61Q5/008 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/10 ,  C08F226/10

Abstract: What is provided herein are strongly swellable, moderately crosslinked polyvinylpyrrolidone polymers in the form of fine, white powders characterized by (a) an aqueous swelling parameter defined by its gel volume of about 15 to 150 ml/g, (b) a Brookfield viscosity in 5 % aqueous solution of at least about 10.000 cps, and (c) being prepared directly by a precipitation polymerization process in an organic solvent, in the presence of about 0,2 to 1 % by weight of vinylpyrrolidone, of a multifunctional crosslinking agent, preferably about 0.25 to 0.8 %, and optimally, about 0.35 to 0.6 %. Those polymers in the amount of 0.2 to 10 % by wt. are included in cosmetic compositions for the care of hair and skin.

Abstract translation: 本文提供的是可膨胀的中等交联的聚乙烯吡咯烷酮聚合物，其为细的白色粉末形式，其特征在于（a）由其凝胶体积约15至150ml / g定义的水溶胀参数，（b） 5％的水溶液，至少约10.000cps，和（c）通过沉淀聚合法在有机溶剂中，在约0.2-1％（重量）的乙烯基吡咯烷酮的存在下直接制备多官能交联剂， 优选约0.25至0.8％，最佳为约0.35至0.6％。 这些聚合物的量为0.2〜10重量％。 被包括在用于护理头发和皮肤的化妆品组合物中。

公开(公告)号：WO1992002205A1

公开(公告)日：1992-02-20

申请号：PCT/US1991004329

申请日：1991-06-17

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  HELIOFF, Michael, W. ,  TAZI, Mohammed ,  LOGIN, Robert, B. ,  KWAK, Yoon, T.

IPC: A61K07/11

CPC classification number: A61K8/042 ,  A61K8/8164 ,  A61Q5/06 ,  Y10S514/944

Abstract: This invention relates to a hair styling gel containing a neutralized, crosslinked maleic anhydride-C1-C5 alkyl vinyl ether copolymer. The formulation is a clear gel of suitable viscosity and pH which provides effective hair styling at low copolymer levels with no drag on comb-out and a clean feel on the hair after use.

公开(公告)号：WO1992007546A1

公开(公告)日：1992-05-14

申请号：PCT/US1991005074

申请日：1991-07-18

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  HELIOFF, Michael, W. ,  PLOCHOCKA, Krystyna ,  TAZI, Mohammed

IPC: A61K07/075

CPC classification number: A61Q5/06 ,  A61K8/046 ,  A61K8/8164 ,  A61Q5/02

Abstract: The hair setting shampoo composition comprises a resin provided by about 1-15 % by weight of about a 20-50 % resin active alcoholic solution of the alkyl half-ester of a C1-C5 alkyl vinyl ether-maleic anhydride copolymer having a molecular weight of at least one million, which is about 5-90 % neutralized, preferably with about 0.01-1 % by weight of 2-amino-2-methyl-1-propanol, about 5-60 % by weight of a surfactant, optionally 0-10 % by weight of added ethanol, and about 30-90 % by weight of water. The composition provides a subtle temporary set on hair of the user without the use of auxiliary fixatives in the composition. The mousse hair composition includes 3-15 % by weight of the alcoholic solution of the resin, 60-95 % by weight of water, 0.3-2.0 % by weight of a surfactant, and 0-30 % by weight of added ethanol.

Abstract translation: 头发定型洗发剂组合物包含树脂，其由约1-15重量％的约20-50％的具有分子量的C 1 -C 5烷基乙烯基醚 - 马来酸酐共聚物的烷基半酯的树脂活性醇溶液 至少一百万，约5-90％中和，优选约0.01-1重量％的2-氨基-2-甲基-1-丙醇，约5-60重量％的表面活性剂，任选地0 -10重量％的添加的乙醇和约30-90重量％的水。 该组合物在使用者的头发上提供微妙的临时固定，而不需要在组合物中使用辅助固定剂。 摩丝发组合物包含3-15重量％的树脂醇溶液，60-95重量％的水，0.3-2.0重量％的表面活性剂和0-30重量％的加入的乙醇。

公开(公告)号：EP0313561B1

公开(公告)日：1992-12-02

申请号：EP87903993.1

申请日：1987-06-15

Applicant: ISP INVESTMENTS INC.

Inventor： HELIOFF, Michael, W. ,  BIRES, Carmen, D. ,  LOGIN, Robert, B.

IPC: C07D207/27 ,  C07D211/76 ,  C07D223/10

CPC classification number: C11D3/32 ,  A01N25/04 ,  A01N25/14 ,  A61K8/4913 ,  A61Q5/04 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10 ,  C07D499/00 ,  C11D1/58

Abstract: A composition comprising an aqueous preparation on the basis of keratin softening, which contains as a swelling and penetration agent, an N-alkyl pyrrolidone wherein the alkyl group contains between 8 and 22 carbon atoms.

公开(公告)号：EP0311632B1

公开(公告)日：1996-05-29

申请号：EP87904340.4

申请日：1987-06-16

Applicant: ISP INVESTMENTS INC.

Inventor： LOGIN, Robert, B. ,  CHAUDHURI, Ratan, K. ,  HASHEM, Mohamed, M. ,  HELIOFF, Michael, W. ,  PRITCHARD, David, W. ,  RUPPERT, Ronald, M. ,  SAVIO, Lenore, E. ,  SUWALA, David, W. ,  TRACY, David, J.

IPC: C07D207/267 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10

CPC classification number: C11D3/32 ,  A01N25/04 ,  A01N25/14 ,  A61K8/4913 ,  A61Q3/00 ,  A61Q5/02 ,  A61Q9/02 ,  A61Q13/00 ,  A61Q17/005 ,  A61Q17/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10 ,  C02F1/683 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10 ,  C09D9/00 ,  C09G1/00 ,  C11D1/58 ,  C11D3/28

Abstract: N-hydrocarbon substituted lactams, particularly N-alkyl substituted lactams having formula (A), wherein R' is a hydrophobic radical such as linear or branched chain alkyl group containing from 8 to 20 carbon atoms, most preferably 8 to 14 carbon atoms; which lactams are capable of forming micelles in aqueous solutions irrespective of pH and have critical micelle concentrations of between about 1 x 10-3 and about 1 x 10-5 moles per liter. The invention also relates to the uses of the N-hydrocarbon substituted lactams which involve surfactant properties, such as solubility, wetting, viscosity building, emulsifying, foam boosting and/or complexing properties.