公开(公告)号：KR20080093585A

公开(公告)日：2008-10-22

申请号：KR20070037473

申请日：2007-04-17

Applicant: KOREA BASIC SCIENCE INST

Inventor： KIM SUNG HWAN ,  KIM HYUN SIK ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN

IPC: G01N27/62 ,  G01N24/14

CPC classification number: G01N27/622

Abstract: An apparatus for signal improvement of a fourier transform ion cyclotron resonance(FT-ICR) mass spectrometer is provided to stabilize the motion of activated ions by applying an optimized voltage to each electrode. An apparatus for signal improvement of a fourier transform ion cyclotron resonance(FT-ICR) mass spectrometer comprises trapping electrodes(10) separated from the front and rear surfaces, activating and detecting electrodes(11), first adjusting electrodes(12), and second adjusting electrodes(13). The activating and detecting electrodes placed between the trapping electrodes has a trap. The first adjusting electrodes are connected to the activating and detecting electrode via a capacitor. The second adjusting electrodes, a portion of the trapping electrodes, are electrically isolated.

Abstract translation: 提供了一种用于信号改善的傅里叶变换离子回旋共振（FT-ICR）质谱仪的装置，通过对每个电极施加优化的电压来稳定活化离子的运动。 一种用于信号改进的装置，其特征在于包括：从前表面和后表面分离的电极（10），激活和检测电极（11），第一调节电极（12）和第二调整电极 调节电极（13）。 置于捕获电极之间的激活和检测电极具有陷阱。 第一调节电极通过电容器连接到激活和检测电极。 第二调节电极，一部分捕获电极被电隔离。

公开(公告)号：KR100659263B1

公开(公告)日：2006-12-12

申请号：KR20060007815

申请日：2006-01-25

Applicant: KOREA BASIC SCIENCE INST

Inventor： KIM SEUNG YONG ,  HUR MAN HOI ,  KIM SUNG HWAN ,  KIM HYUN SIK ,  YOO JONG SHIN

IPC: G01N27/62

Abstract: A method for controlling a tandem mass analyzer of pipeline type is provided to independently operate a test material injection section, a first ion transfer section, an ion selection/separation section, an ion collision section, and a second ion transfer section. A method for controlling a tandem mass analyzer of pipeline type includes the steps of: operating a first ion transfer section and operating a second ion transfer section by a control unit(S28); operating an ion selection/separation section and operating a trap section by the control unit(S29); and colliding ions selected or separated by the ion selection/separation section and dividing the ions into a small size and discharging the ions and operating the test material injection section(S29a).

Abstract translation: 提供了一种用于控制管道类型的串联质量分析器的方法，以独立地操作测试材料注入部分，第一离子转移部分，离子选择/分离部分，离子碰撞部分和第二离子转移部分。 一种用于控制管道类型的串联质量分析器的方法包括以下步骤：操作第一离子转移部分并通过控制单元操作第二离子转移部分（S28）; 操作离子选择/分离部分并由控制单元操作陷阱部分（S29）; 和离子选择/分离部选择或分离的离子碰撞，并将离子分成小尺寸并排出离子并操作测试材料注入部分（S29a）。

公开(公告)号：EP2519816A4

公开(公告)日：2014-04-16

申请号：EP10841161

申请日：2010-12-15

Applicant: KOREA BASIC SCIENCE INST

Inventor： PARK KYU HWAN ,  KIM HYUN SIK ,  KWON KYUNG HOON ,  YOO JONG SHIN

IPC: G01N30/72 ,  B01D15/08 ,  G01N30/86 ,  G01N33/15 ,  G01N33/68

CPC classification number: G01N30/06 ,  G01N30/8686 ,  G01N30/96 ,  G01N33/6848 ,  G01N2030/8809 ,  G01N2030/8813 ,  G01N2500/00 ,  Y10T436/174614 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375

Abstract: A method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining mass profiles based on mass spectra resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.

公开(公告)号：DE102008064246B4

公开(公告)日：2013-02-21

申请号：DE102008064246

申请日：2008-12-22

Applicant: KOREA BASIC SCIENCE INST

Inventor： CHOI MYOUNG CHOUL ,  CHOI YEON SUK ,  LEE JEONG MIN ,  KIM SEUNG YONG ,  KIM DONG LAK ,  KIM HYUN SIK ,  YOO JONG SHIN ,  STAHL STEFAN KARL-HEINZ

IPC: H01J49/26 ,  G01N27/62 ,  H01J49/38

Abstract: Fouriertransformation-Ionenzyklotronresonanz-Massenspektrometer, das umfasst: eine Ionisierungsquelle (101), um eine Probe einzuleiten, ein Massenfilter (102), um ein in eine Vakuumkammer eingeleitetes Ion auszuwählen und zu speichern, eine Kollisionszelle (103) und einen Ionenübertragungsleiter (104), um das gespeicherte Ion zu einer Ionenzyklotronresonanz-Falle (105) zu übertragen, die ein Signal misst, wobei die Ionisierungsquelle (101), der Massenfilter (102), die Kollisionszelle (103), der Ionenübertragungsleiter (104) und die Ionenzyklotronresonanz-Falle (105) in der Vakuumkammer angeordnet sind, gekennzeichnet durch ein Erfassungssystem, das einen Kryo-Vorverstärker (200) aufweist, der die Signale der Ionenzyklotronresonanz-Falle (105) verstärkt, und der in der Vakuumkammer so nahe wie möglich bei der Ionenzyklotronresonanz-Falle (105) installiert ist, und ein Kryo-Kühlungssystem (300), das einen Kryo-Kühler (301) und ein Kryogen-Zirkulationsrohr (302, 302-1) aufweist, die außerhalb der Vakuumkammer installiert sind, um den Kryo-Vorverstärker (200) zu kühlen, und einen Kryo-Kühlungsflansch (303), der am dem Kryo-Kühlsystem (300) zugewandten Ende der Vakuumkammer vorgesehen ist und der...

公开(公告)号：DE102008064246A1

公开(公告)日：2009-07-09

申请号：DE102008064246

申请日：2008-12-22

Applicant: KOREA BASIC SCIENCE INST

Inventor： CHOI MYOUNG CHOUL ,  CHOI YEON SUK ,  LEE JEONG MIN ,  KIM SEUNG YONG ,  KIM DONG LAK ,  KIM HYUN SIK ,  YOO JONG SHIN ,  STAHL STEFAN KARL-HEINZ

IPC: H01J49/26 ,  G01N27/62

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) is provided. A preamplifier is installed as nearest to an ion cyclotron resonance (ICR) trap as possible at a detector part in the mass spectrometer, and thermal noise generated at the preamplifier is minimized by means of a cryo-cooling system to increase a signal-to-noise ratio of ion detection signals such that an ultra-low amount of specimen can be detected, which was impossible in the related art.

公开(公告)号：DE112006003731T5

公开(公告)日：2008-12-11

申请号：DE112006003731

申请日：2006-09-12

Applicant: KOREA BASIC SCIENCE INST

Inventor： KIM HYUN SIK ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN

IPC: G01N27/62

Abstract: A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT-ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method. Also, a high resolution and with sensitivity measurement can be achieved. Moreover, when a reagent gas instead of a collision gas in the collision cell is injected, the gas phase reaction of the selected ions and the reagent gas can be observed, and the mass of the ions generated in the gas phase reaction can be measured.