公开(公告)号：JP2008117738A

公开(公告)日：2008-05-22

申请号：JP2006320747

申请日：2006-11-28

Applicant: Korea Basic Science Inst ,  コリア ベーシック サイエンス インスティテュート

Inventor： KIM SUNG HWAN ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN ,  KIM HYUN SIK

IPC: H01J49/38 ,  G01N27/62

CPC classification number: H01J49/38

Abstract: PROBLEM TO BE SOLVED: To provide a method of improving signals by changing voltage applied to an analysis trap of a high resolution Fourier transform ion cyclotron resonance mass spectrometer (FT-ICRMS) according to measurement stages, and in details, provide a method in which independent voltage different from a trap electrode is applied on an electrode added to the center part of the trap electrode after ions are activated and this is maintained until one measurement cycle is over.
SOLUTION: When the method is applied, stability of ions confined in the trap becomes higher and a measured time region signal becomes longer. As for the time region signal that becomes longer, resolution and sensitivity of frequency or the region signal of a mass/charge ratio are enhanced.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种通过根据测量阶段改变施加到高分辨率傅里叶变换离子回旋共振质谱仪（FT-ICRMS）的分析阱的电压来改善信号的方法，并且具体地，提供一种 在离子被激活之后，在与陷阱电极的中心部分相加的电极上施加与捕获电极不同的独立电压的方法，直到一个测量周期结束。 解决方案：当应用该方法时，限制在阱中的离子的稳定性变得更高，并且测量的时间区域信号变得更长。 对于变长的时间区域信号，提高了频率的分辨率和灵敏度或质量/电荷比的区域信号。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008130534A

公开(公告)日：2008-06-05

申请号：JP2006320702

申请日：2006-11-28

Applicant: Korea Basic Science Inst ,  コリア ベーシック サイエンス インスティテュート

Inventor： CHOI MYOUNG CHOUL ,  KIM HYUN SIK ,  KIM SUNG HWAN ,  YOO JONG SHIN

IPC: H01J49/06 ,  G01N27/62 ,  H01J49/38

CPC classification number: H01J49/063

Abstract: PROBLEM TO BE SOLVED: To provide a hybrid ion transmitting device for enhancing transmission efficiency of an RF ion transmitting tube to which a gate valve is attached by using an electrostatic lens. SOLUTION: This hybrid ion transmitting device for enhancing detection sensitivity and resolution by using an electrostatic lens ion transmitting tube in the front, enabling use of a gate valve in the middle, and using an RF ion transmitting tube having good transmission efficiency in a high electric field in the back can be manufactured by combination of the electrostatic lens and the RF ion transmitting tube. That is, the hybrid ion transmitting device has a structure in which the electrostatic lens for transmitting injected ions and applying a voltage so that the ions can be focused on the center of the ion transmitting direction axis and the RF ion transmitting tube connected to the electrostatic lens to pass the ions focused on the center of the ion transmitting direction axis are connected through the gate valve. By this structure, the ion transmission efficiency is enhanced, and signal attenuation caused by collision with surrounding neutral gas is suppressed as much as possible by providing a stable vacuum state, and the hybrid ion transmitting device can enhance detection sensitivity and resolution thereby. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于通过使用静电透镜来提高安装有闸阀的RF离子传输管的传输效率的混合离子传输装置。 解决方案：该混合离子传输装置用于通过使用前面的静电透镜离子透射管来提高检测灵敏度和分辨率，从而能够使用中间的闸阀，并且使用具有良好传输效率的RF离子传输管 可以通过静电透镜和RF离子传输管的组合来制造背面的高电场。 也就是说，混合离子发射装置具有这样的结构，其中静电透镜用于传输注入的离子并施加电压，使得离子可以聚焦在离子传输方向轴的中心和连接到静电的RF离子传输管 透镜通过聚焦在离子传播方向轴中心的离子通过闸阀连接。 通过这种结构，离子传递效率提高，并且通过提供稳定的真空状态尽可能地抑制与周围中性气体的碰撞引起的信号衰减，并且混合离子发射装置可以提高检测灵敏度和分辨率。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：WO2012074234A3

公开(公告)日：2012-07-26

申请号：PCT/KR2011008866

申请日：2011-11-21

Applicant: KOREA BASIC SCIENCE INST ,  CHOI MYOUNG CHOUL ,  PARK A LEUM ,  KIM HYUN SIK ,  KIM SEUNG YONG ,  YOO JONG SHIN

Inventor： CHOI MYOUNG CHOUL ,  PARK A LEUM ,  KIM HYUN SIK ,  KIM SEUNG YONG ,  YOO JONG SHIN

IPC: G01N27/62 ,  H01J49/26

CPC classification number: H01J49/02 ,  H01J49/0027 ,  H01J49/065 ,  H01J49/38

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.

Abstract translation: 傅立叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 一个减速透镜，在该减速透镜上，由电离源产生并在空间上分散的离子入射，有选择地使入射离子减速，从而减小离子之间的距离; 以及其上通过减速透镜的离子入射在其上的离子回旋共振单元。 通过防止因质量差引起的离子扩散并使用减速透镜会聚离子，可以延长一次可测量的质量范围。 而且，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

公开(公告)号：KR101146229B1

公开(公告)日：2012-05-17

申请号：KR20100129681

申请日：2010-12-17

Applicant: KOREA BASIC SCIENCE INST

Inventor： KIM SEUNG YONG ,  KIM HYUN SIK ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN

IPC: H01J49/26 ,  G01N27/62

CPC classification number: H01J49/02 ,  H01J49/022 ,  H01J49/38

Abstract: PURPOSE: A control device for improving signal capability of an ion cyclotron resonance mass spectrograph is provided to improve signal sensibility by supplying voltage for ion movement and controlling deflection. CONSTITUTION: An excitation electrode control means applies a high frequency signal or a control signal from a high-frequency amplifier(7) to a first excitation electrode and a second excitation electrode. A detection electrode control means applies an arbitrary waveforms generated in first and second control signal generating units(21, 23) to each detection electrode. A detection electrode signal processing signal detects an ion signal from first and second detection electrodes and amplifies and changes the ion signal into a digital signal. An excitation electrode signal processing means detects an ion signal from the first and second excitation electrodes. The excitation electrode signal processing means amplifies and changes the ion signal into the digital signal. A first excitation switching unit(12) selectively outputs by a computer control program.

Abstract translation: 目的：提供一种用于提高离子回旋共振质谱仪信号能力的控制装置，通过提供离子运动电压和控制偏转来提高信号灵敏度。 构成：励磁电极控制装置将高频信号或来自高频放大器（7）的控制信号施加到第一激励电极和第二激励电极。 检测电极控制装置将在第一和第二控制信号产生单元（21,23）中产生的任意波形施加到每个检测电极。 检测电极信号处理信号检测来自第一和第二检测电极的离子信号，并将离子信号放大并变换为数字信号。 励磁电极信号处理装置检测来自第一和第二激励电极的离子信号。 激励电极信号处理装置将离子信号放大并变换为数字信号。 第一激励切换单元（12）通过计算机控制程序有选择地输出。

公开(公告)号：WO2011081352A2

公开(公告)日：2011-07-07

申请号：PCT/KR2010009254

申请日：2010-12-23

Applicant: KOREA BASIC SCIENCE INST ,  KANG DUK JIN ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN ,  KIM HYUN SIK

Inventor： KANG DUK JIN ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN ,  KIM HYUN SIK

IPC: G01N27/26 ,  G01N33/48 ,  G01N33/68 ,  H01J49/04

CPC classification number: H01J49/165 ,  H01J49/045

Abstract: An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.

Abstract translation: 一种用于电喷雾电离的设备可以包括：平台，其包括入口端口，连接到入口端口的第一通道，连接到第一通道的第二通道和连接到第二通道的出口端口; 雾化器，其设置在所述第一通道中并且被配置为将惰性气体喷射到通过所述入口喷射到所述第一通道中的样品; 以及聚焦透镜，其设置在第二通道中并且被配置为将从喷射样本产生的离子聚焦到出口端口。

公开(公告)号：WO2011078544A2

公开(公告)日：2011-06-30

申请号：PCT/KR2010009141

申请日：2010-12-21

Applicant: KOREA BASIC SCIENCE INST ,  CHOI MYOUNG CHOUL ,  KIM HYUN SIK ,  YOO JONG SHIN

Inventor： CHOI MYOUNG CHOUL ,  KIM HYUN SIK ,  YOO JONG SHIN

IPC: H01J37/30 ,  H01J49/26

CPC classification number: H01J37/08 ,  H01J49/0404 ,  H01J49/067 ,  H01J2237/083

Abstract: An ion injector may include: a first electrode comprising a first region allowing ions to pass; and a second electrode disposed to enclose one end of the first electrode. The second electrode may include: a second region aligned with the first region to allow the ions to pass; and a protruding portion extending along the path of the ions passing through the second region. A mass spectrometer may be configured by disposing the ion injector adjacent to a skimmer.

Abstract translation: 离子注入器可以包括：第一电极，其包括允许离子通过的第一区域; 以及设置成包围第一电极的一端的第二电极。 第二电极可以包括：与第一区域对准的第二区域以允许离子通过; 以及沿着穿过第二区域的离子的路径延伸的突出部分。 可以通过将离子注入器邻近于撇渣器来配置质谱仪。

公开(公告)号：KR20120039839A

公开(公告)日：2012-04-26

申请号：KR20100101270

申请日：2010-10-18

Applicant: KOREA BASIC SCIENCE INST

Inventor： CHOI MYOUNG CHOUL ,  KIM HYUN SIK ,  KIM SEUNG YONG

IPC: G01N27/62 ,  H01L21/265 ,  H05H13/00

CPC classification number: H01J49/38

Abstract: PURPOSE: A Fourier transform ion cyclotron resonance mass spectrometer using ultra-wideband RF amplifier and a method for improving signal of Fourier transform ion cyclotron resonance mass spectrometer are provided to add DC offset to high voltage signal by using wide operation frequency range. CONSTITUTION: A Fourier transform ion cyclotron resonance mass spectrometer comprises a signal generating unit(10), a voltage amplifier(20), a ion cyclotron trap(30). The signal generating unit generates a sine wave shaped first voltage signal having DC offset. The voltage amplifier receives the first voltage signal from the signal generating unit, and generates a second voltage signal. The ion cyclotron trap receives the second voltage signal, and generates ion cyclotron action around the location determined by the DC offset.

Abstract translation: 目的：提供使用超宽带RF放大器的傅里叶变换离子回旋共振质谱仪和傅里叶变换离子回旋共振质谱仪的信号改进方法，通过使用宽工作频率范围向高压信号增加直流偏移。 构成：傅里叶变换离子回旋共振质谱仪包括信号发生单元（10），电压放大器（20），离子回旋加速器捕集器（30）。 信号产生单元产生具有DC偏移的正弦波状的第一电压信号。 电压放大器从信号发生单元接收第一电压信号，并产生第二电压信号。 离子回旋收集器接收第二电压信号，并且在由DC偏移确定的位置周围产生离子回旋加速器作用。

公开(公告)号：KR20080093585A

公开(公告)日：2008-10-22

申请号：KR20070037473

申请日：2007-04-17

Applicant: KOREA BASIC SCIENCE INST

Inventor： KIM SUNG HWAN ,  KIM HYUN SIK ,  CHOI MYOUNG CHOUL ,  YOO JONG SHIN

IPC: G01N27/62 ,  G01N24/14

CPC classification number: G01N27/622

Abstract: An apparatus for signal improvement of a fourier transform ion cyclotron resonance(FT-ICR) mass spectrometer is provided to stabilize the motion of activated ions by applying an optimized voltage to each electrode. An apparatus for signal improvement of a fourier transform ion cyclotron resonance(FT-ICR) mass spectrometer comprises trapping electrodes(10) separated from the front and rear surfaces, activating and detecting electrodes(11), first adjusting electrodes(12), and second adjusting electrodes(13). The activating and detecting electrodes placed between the trapping electrodes has a trap. The first adjusting electrodes are connected to the activating and detecting electrode via a capacitor. The second adjusting electrodes, a portion of the trapping electrodes, are electrically isolated.

Abstract translation: 提供了一种用于信号改善的傅里叶变换离子回旋共振（FT-ICR）质谱仪的装置，通过对每个电极施加优化的电压来稳定活化离子的运动。 一种用于信号改进的装置，其特征在于包括：从前表面和后表面分离的电极（10），激活和检测电极（11），第一调节电极（12）和第二调整电极 调节电极（13）。 置于捕获电极之间的激活和检测电极具有陷阱。 第一调节电极通过电容器连接到激活和检测电极。 第二调节电极，一部分捕获电极被电隔离。

公开(公告)号：DE102008064246B4

公开(公告)日：2013-02-21

申请号：DE102008064246

申请日：2008-12-22

Applicant: KOREA BASIC SCIENCE INST

Inventor： CHOI MYOUNG CHOUL ,  CHOI YEON SUK ,  LEE JEONG MIN ,  KIM SEUNG YONG ,  KIM DONG LAK ,  KIM HYUN SIK ,  YOO JONG SHIN ,  STAHL STEFAN KARL-HEINZ

IPC: H01J49/26 ,  G01N27/62 ,  H01J49/38

Abstract: Fouriertransformation-Ionenzyklotronresonanz-Massenspektrometer, das umfasst: eine Ionisierungsquelle (101), um eine Probe einzuleiten, ein Massenfilter (102), um ein in eine Vakuumkammer eingeleitetes Ion auszuwählen und zu speichern, eine Kollisionszelle (103) und einen Ionenübertragungsleiter (104), um das gespeicherte Ion zu einer Ionenzyklotronresonanz-Falle (105) zu übertragen, die ein Signal misst, wobei die Ionisierungsquelle (101), der Massenfilter (102), die Kollisionszelle (103), der Ionenübertragungsleiter (104) und die Ionenzyklotronresonanz-Falle (105) in der Vakuumkammer angeordnet sind, gekennzeichnet durch ein Erfassungssystem, das einen Kryo-Vorverstärker (200) aufweist, der die Signale der Ionenzyklotronresonanz-Falle (105) verstärkt, und der in der Vakuumkammer so nahe wie möglich bei der Ionenzyklotronresonanz-Falle (105) installiert ist, und ein Kryo-Kühlungssystem (300), das einen Kryo-Kühler (301) und ein Kryogen-Zirkulationsrohr (302, 302-1) aufweist, die außerhalb der Vakuumkammer installiert sind, um den Kryo-Vorverstärker (200) zu kühlen, und einen Kryo-Kühlungsflansch (303), der am dem Kryo-Kühlsystem (300) zugewandten Ende der Vakuumkammer vorgesehen ist und der...

公开(公告)号：DE102008064246A1

公开(公告)日：2009-07-09

申请号：DE102008064246

申请日：2008-12-22

Applicant: KOREA BASIC SCIENCE INST

Inventor： CHOI MYOUNG CHOUL ,  CHOI YEON SUK ,  LEE JEONG MIN ,  KIM SEUNG YONG ,  KIM DONG LAK ,  KIM HYUN SIK ,  YOO JONG SHIN ,  STAHL STEFAN KARL-HEINZ

IPC: H01J49/26 ,  G01N27/62

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) is provided. A preamplifier is installed as nearest to an ion cyclotron resonance (ICR) trap as possible at a detector part in the mass spectrometer, and thermal noise generated at the preamplifier is minimized by means of a cryo-cooling system to increase a signal-to-noise ratio of ion detection signals such that an ultra-low amount of specimen can be detected, which was impossible in the related art.