公开(公告)号：EP1383539B1

公开(公告)日：2006-07-26

申请号：EP02758920.9

申请日：2002-08-14

Applicant: Korea Institute of Science and Technology ,  Jakwang Co., Ltd.

Inventor： KWON, Ick Chan ,  KIM, In-San ,  JEONG, Seo Young ,  CHUNG, Hesson ,  CHO, Yong Woo ,  SON, Yoen Ju, 106-1404 Sinkongduk samsung Apt. ,  PARK, Chong Rae, Ga-102 Seoul Univ. kyosu Apt. ,  SEO, Sang, Bong

IPC: A61P35/00

CPC classification number: A61K31/704 ,  A61K47/61 ,  A61K47/6907

Abstract: The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.

公开(公告)号：EP1263468A1

公开(公告)日：2002-12-11

申请号：EP01912555.8

申请日：2001-03-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： JEONG, Seo Young ,  KWON, Ick Chan ,  CHUNG, Hesson

IPC: A61K47/06

CPC classification number: A61K9/1075 ,  A61K9/19

Abstract: The present invention relates to an anhydrous liquid composition wherein monoglyceride is mixed with an emulsifier and a solvent, and the manufacturing method thereof, and more specifically, to an anhydrous liquid composition wherein monoglyceride is mixed with a water-insoluble material, an emulsifier and a solvent, and the manufacturing method thereof. Further, the present invention relates to a lyophilized powder and the manufacturing method thereof, wherein the lyophilized powder is prepared by dissolving the mixed liquid composition in water, adding with a cryoprotectant followed by the lyophilization. In the process of dispersion, the lyophilized liquid composition and the powder of the present invention can spontaneously generate particles of 200-500 nm by gently shaking with hands without a powerful mechanical force. Also the lyophilized liquid composition and the powder of the present invention are physicochemically stable since they neither contain water that causes oxidation or hydrolysis upon storage nor undergo phase separation. Considering all the raw materials of the present invention are biocompatible, the present invention will be useful in medical and pharmaceutical fields such as drug delivery.

公开(公告)号：EP3459567B1

公开(公告)日：2020-09-23

申请号：EP18164779.3

申请日：2018-03-28

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Kwangmeyung ,  KWON, Ick Chan ,  PARK, Juho

IPC: A61K47/65 ,  A61K47/69 ,  A61K31/704 ,  A61P35/00

公开(公告)号：EP3508221A1

公开(公告)日：2019-07-10

申请号：EP18166390.7

申请日：2018-04-09

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Kwangmeyung ,  KWON, Ick Chan ,  PARK, Juho

IPC: A61K41/00 ,  A61K47/65 ,  A61K47/55 ,  A61K47/69 ,  A61P35/00

Abstract: The present disclosure relates to a tumor-targeting photosensitizer-drug conjugate, more particularly to one which exhibits superior specific activity for a tumor tissue, is effectively accumulated in the tumor tissue and exhibits the medicinal effect of an anticancer agent with little systemic toxicity as a DEVD peptide is cleaved by caspase-3 and released topically from a prodrug form.

公开(公告)号：EP2431378A2

公开(公告)日：2012-03-21

申请号：EP10775037.4

申请日：2010-03-02

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Kwang Meyung ,  KWON, Ick Chan ,  CHOI, Kui Won ,  LEE, Seung Young ,  YOUN, In Chan ,  HUH, Myung Sook ,  LEE, So Jin

IPC: C07H21/00 ,  C12N15/87

CPC classification number: C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2320/32 ,  C12N2320/51

Abstract: The present invention relates to a high-molecular weight oligonucleotides polymerization method which increases in vivo stability, and to the use of a high-molecular weight oligonucleotides prepared by the polymerization method.
The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.

Abstract translation: 本发明涉及一种增加在体内的稳定性，并涉及使用通过聚合方法制备的高分子量的寡核苷酸的高分子量的寡核苷酸的聚合方法。 在寡核苷酸具有小分子量可容易地聚合成高分子量的寡核苷酸做了本发明的寡核苷酸的聚合方法是有利的。 此外，通过本发明的方法制备的高分子的寡核苷酸能结合到亲水性高分子材料或无机材料，然后可以稳定地输送到活体。 因此，通过本发明的方法制备的高分子的寡核苷酸，可广泛用于治疗各种疾病。

公开(公告)号：EP1835888A1

公开(公告)日：2007-09-26

申请号：EP06702900.9

申请日：2006-01-12

Applicant: Korea Institute of Science and Technology

Inventor： KWON, Ick Chan ,  JEONG, Seo Young ,  KIM, In-san ,  CHUNG, Hesson ,  SEO, Sang Bong Jakwang Co., Ltd. ,  PARK, Jae Hyung ,  KWON, Seunglee ,  KIM, Kwangmyung ,  KIM, Jong-ho

IPC: A61K9/00

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5161 ,  A61K47/61

Abstract: Disclosed are a cholanic acid-chitosan complex forming self-aggregates and a preparation method thereof, and more particularly, a cholanic acid-chitosan complex which is composed of hydrophobic cholanic acid and hydrophilic chitosan and forms self-aggregates in an aquatic environment, and a method of preparing the cholanic acid- chitosan complex. The cholanic acid-chitosan complex forms self -aggregates, which prolong the drug release period, enhance the selectivity of the complex for tumor tissue, and greatly increase drug loading content when a drug is incorporated into the self -aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the cholanic acid-chitosan complex is useful for anticancer chemotherapy.

公开(公告)号：EP1272529A1

公开(公告)日：2003-01-08

申请号：EP00981902.0

申请日：2000-11-30

Applicant: Korea Institute of Science and Technology

Inventor： JEONG, Seo, Young ,  BAE, Eunhee ,  KWON, Ick Chan ,  CHOI, Kuiwon

IPC: C08B37/08 ,  C12N11/16

CPC classification number: C08J9/28 ,  C08B37/003 ,  C08J2201/0484 ,  C08J2305/08 ,  C08L5/08 ,  C12N5/0075 ,  C12N2533/72

Abstract: The present invention relates to macroporous chitosan beads having 5-200 νm in size of relatively large and uniform pores that are distributed from surface to core region, and a preparation method thereof comprising the following steps: by dropping chitosan solution, aqueous chitosan solution or their mixture into the low-temperature of organic solvent or liquid nitrogen; and by regulating pore size by phase separation method via temperature difference. The macroporous chitosan beads of the present invention make cell culture more efficient than the previous substrate, since cell can attach to them efficiently due to their large surface area, it is easy for cell to be injected into them and cell attached to them can exist longer due to their three-dimensional structure, therefore they can be used for a study about production of protein, antibiotics, anticancer agent, polysaccharide, physiologically active agent, animal hormone, or plant hormone as well as a study about substitution of metabolic organs, cartilage or bone.

Abstract translation: 本发明涉及大孔径壳聚糖珠粒及其制备方法，所述大孔径壳聚糖粒子的粒径为5〜200ν，具有较大且均匀的孔隙，分布于表面至核心区域，包括以下步骤：将壳聚糖溶液，壳聚糖水溶液或其 混合物转化为低温的有机溶剂或液氮; 并通过温度差通过相分离法调节孔径。 本发明的大孔脱乙酰壳多糖珠粒使细胞培养比先前的基质更有效，因为细胞由于它们的大表面积而可以有效地附着到它们上，细胞很容易注入它们并且细胞附着在它们上的时间可以更长 由于它们的三维结构，因此它们可以用于研究蛋白质，抗生素，抗癌剂，多糖，生理活性剂，动物激素或植物激素的生产以及代谢器官，软骨替代的研究 或骨头。

公开(公告)号：EP1100464A1

公开(公告)日：2001-05-23

申请号：EP99935145.5

申请日：1999-07-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： JEONG, Seo Young ,  KWON, Ick Chan ,  CHUNG, Hesson

IPC: A61K9/107

CPC classification number: A61K9/5123 ,  A61K9/1075 ,  A61K9/1272 ,  A61K48/00 ,  C12N15/88

Abstract: The present invention relates to oil-in-water lipid emulsions composed of non-triglyceride oils and solid lipid nanoparticles (SLN) composed of triglyceride or ethyl stearate used as gene transfection agents and drug delivery systems and method for preparing thereof. The present invention also concerns the method of transferring genes or drugs efficiently into cells by using the lipid emulsions and solid lipid nanoparticles. Also the present invention relates to the method of preparing lipid emulsions containing lipophilic or amphiphilic drugs by using squalene or squalane as the core-oil. The present invention also concerns the method of preparing the solid lipid nanoparticles containing lipophilic or amphiphilic drugs by using ethyl stearate as the core-fat.