公开(公告)号：EP4169916A1

公开(公告)日：2023-04-26

申请号：EP21826659.1

申请日：2021-06-18

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  LEE, Haeun ,  SON, Woo Seung ,  LEE, Hye Yeon

IPC: C07D403/12 ,  A61K31/506 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61P25/28 ,  C07D241/24 ,  C07D401/12 ,  C07D417/04 ,  C07D213/56

Abstract: Provided are novel carbonohydrazonoyl dicyanide compounds including two or more aryl or heteroaryl groups connected via a linker and uses thereof.

公开(公告)号：EP3838896A1

公开(公告)日：2021-06-23

申请号：EP19849176.3

申请日：2019-08-19

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  PAE, Ae Nim ,  LIM, Sang Min ,  PARK, Jong Hyun ,  CHOI, Ji Won ,  KIM, Siwon ,  KIM, Hyeon Jeong ,  YEON, Seul Ki

IPC: C07D401/12 ,  A61K31/44 ,  A61K31/496 ,  A61K31/5355 ,  C07D413/12

Abstract: The present invention relates to a novel halo-(3-(phenylsulfonyl)prop-1-enyl)pyridine derivative or a pharmaceutically acceptable salt thereof; a preparation method thereof; and an Nrf2 activator and a pharmaceutical composition for preventing or treating diseases induced by a decrease in Nrf2 activity, both of which comprise the same as an active ingredient.

公开(公告)号：EP3305070B1

公开(公告)日：2020-07-22

申请号：EP17195792.1

申请日：2017-10-10

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Do Hee ,  SHIN, Seul Gi ,  LIM, Sung Su ,  PAE, Ae Nim ,  KIM, Dong Jin ,  KIM, Yun Kyung

IPC: A01K67/027 ,  C12N15/85 ,  G01N33/50 ,  C12N5/073 ,  G01N33/68

公开(公告)号：EP3305070A1

公开(公告)日：2018-04-11

申请号：EP17195792.1

申请日：2017-10-10

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Do Hee ,  SHIN, Seul Gi ,  LIM, Sung Su ,  PAE, Ae Nim ,  KIM, Dong Jin ,  KIM, Yun Kyung

IPC: A01K67/027 ,  C12N15/85 ,  G01N33/50 ,  C12N5/073

Abstract: The present invention relates to a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.

Abstract translation: 本发明涉及用于筛选tau寡聚体形成的载体对，从载体对引入的小鼠胚胎，从小鼠胚胎获得的神经疾病的转基因模型小鼠，以及使用该载体对筛选τ寡聚物形成抑制剂候选物的方法 转基因模型小鼠。 更具体地，本发明提供了用于筛选tau寡聚体形成的载体对，其包含：第一载体，其包含第一tau基因，第一荧光蛋白基因和第一神经元特异性启动子; 以及第二载体，其包含第二tau基因，第二荧光蛋白基因和第二神经元特异性启动子，其中从第一荧光蛋白基因表达的蛋白和从第二荧光蛋白基因表达的蛋白相互结合以显示荧光 通过从第一个tau基因表达的蛋白质和从第二个tau基因表达的蛋白质之间的结合来实现。

公开(公告)号：EP4245749A1

公开(公告)日：2023-09-20

申请号：EP21892368.8

申请日：2021-11-12

Applicant: Institute for Basic Science ,  Korea Institute of Science and Technology

Inventor： LEE, Chang Jun ,  CHUN, Heejung ,  WON, Woojin ,  PARK, Ki Duk ,  PARK, Jong Hyun ,  PAE, Ae Nim ,  CHOI, Ji Won ,  LEE, Elijah ,  PARK, Sun Jun ,  KIM, Hyeon Jeong ,  KIM, Yoowon ,  KIM, Byung Eun ,  KIM, Siwon

IPC: C07C211/53 ,  A61K31/136 ,  A61P25/28 ,  A23L33/10 ,  A23L29/00

Abstract: The present invention provides a novel aminoaromatic compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition that is for preventing or treating neurodegenerative diseases and comprises same as an active ingredient, and a health functional food composition for preventing or ameliorating neurodegenerative diseases.

公开(公告)号：EP4169909A1

公开(公告)日：2023-04-26

申请号：EP21825619.6

申请日：2021-06-18

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  LEE, Haeun ,  SON, Woo Seung ,  LEE, Hye Yeon

IPC: C07D237/04 ,  A61K31/50 ,  A61P25/28 ,  C07D237/14

Abstract: Provided are novel oxopyridazinyl-phenyl-carbonohydrazonoyl dicyanide compounds and uses thereof.

公开(公告)号：EP4169905A1

公开(公告)日：2023-04-26

申请号：EP21825235.1

申请日：2021-06-18

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  LEE, Haeun ,  SON, Woo Seung ,  LEE, Hye Yeon

IPC: C07D217/24 ,  A61K31/472 ,  A61K31/4184 ,  A61K31/428 ,  A61P25/28 ,  C07D235/26 ,  C07D471/04 ,  C07D277/68

Abstract: Provided are novel fused-heterocyclyl-carbonohydrazonoyl dicyanide compounds and uses thereof.

公开(公告)号：EP3901139A1

公开(公告)日：2021-10-27

申请号：EP18944116.5

申请日：2018-12-26

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  SEONG, Jihye ,  LEE, Jae Wook ,  SONG, Ji Yeon ,  SHIN, Seulgi ,  JEONG, Hyean Jeong ,  SON, Woo Seung ,  LEE, Haeun ,  LIM, Da Mi ,  KIM, Seok Kyu ,  AHN, Jee Yun ,  KIM, Chae Won ,  LONDHE, Ashwini Machhindra ,  GOTINA, Lizaveta ,  KIM, Hyojin ,  LEE, Hye Yeon ,  KIM, Nam Gyung ,  CHA, Eunji ,  KIM, Kunhee ,  LIM, Ji Woong

IPC: C07D213/04 ,  A61K31/505 ,  A61K31/425 ,  C07D277/20 ,  C07D241/10 ,  C07D249/08 ,  C07D217/04 ,  C07D231/56 ,  C07D209/04 ,  C07D487/04

Abstract: The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.