公开(公告)号：WO2013147568A1

公开(公告)日：2013-10-03

申请号：PCT/KR2013/002699

申请日：2013-04-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KIM, Dong Jin ,  YOO, Kyung Ho ,  KIM, Young Soo ,  PARK, Woong Seo ,  KANG, Yong Koo ,  KIM, Hye Yun ,  KIM, Yun Kyung ,  PARK, Ki Duk ,  KIM, Maeng Sup ,  SUH, Kwee Hyun ,  AHN, Young Gil

IPC: C07D413/12 ,  C07D307/86 ,  A61K31/421 ,  A61P25/00

CPC classification number: C07D413/12 ,  C07D307/81 ,  C07D405/12

Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.

Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。

公开(公告)号：EP3202759A1

公开(公告)日：2017-08-09

申请号：EP15847985.7

申请日：2015-09-24

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  LEE, Changjoon Justin ,  KIM, Dong Jin ,  PAE, Ae Nim ,  CHOO, Hyun Ah ,  MIN, Sun Joon ,  KANG, Yong Koo ,  KIM, Yun Kyung ,  SONG, Hyo Jung ,  CHOI, Ji Won ,  NAM, Min Ho ,  HEO, Jun Young ,  YEON, Seul Ki ,  JANG, Bo Ko ,  JU, Eun Ji ,  JO, Seon Mi ,  PARK, Jong-Hyun

IPC: C07C237/20 ,  C07C237/04 ,  C07C231/12 ,  C07C309/04 ,  A61K31/16 ,  A61K31/167

Abstract: The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.

Abstract translation: 本公开涉及α-氨基酰胺衍生物化合物和含有其的药物组合物。 根据本公开的各种实施方式，提供了一种治疗剂，其可以克服现有药物用作MAO-B抑制剂的缺点，并且具体地通过非共价键可逆地抑制MAO-B，从而缓解或消除 现有药物通过与MAO-B通过共价键发挥不可逆作用而表现出治疗效果的副作用。 特别地，可以提供与现有可逆MAO-B抑制剂相比具有优良稳定性和功效的新化合物。

公开(公告)号：EP4169916A1

公开(公告)日：2023-04-26

申请号：EP21826659.1

申请日：2021-06-18

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  LEE, Haeun ,  SON, Woo Seung ,  LEE, Hye Yeon

IPC: C07D403/12 ,  A61K31/506 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61P25/28 ,  C07D241/24 ,  C07D401/12 ,  C07D417/04 ,  C07D213/56

Abstract: Provided are novel carbonohydrazonoyl dicyanide compounds including two or more aryl or heteroaryl groups connected via a linker and uses thereof.

公开(公告)号：EP3305070B1

公开(公告)日：2020-07-22

申请号：EP17195792.1

申请日：2017-10-10

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Do Hee ,  SHIN, Seul Gi ,  LIM, Sung Su ,  PAE, Ae Nim ,  KIM, Dong Jin ,  KIM, Yun Kyung

IPC: A01K67/027 ,  C12N15/85 ,  G01N33/50 ,  C12N5/073 ,  G01N33/68

公开(公告)号：EP3305070A1

公开(公告)日：2018-04-11

申请号：EP17195792.1

申请日：2017-10-10

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Do Hee ,  SHIN, Seul Gi ,  LIM, Sung Su ,  PAE, Ae Nim ,  KIM, Dong Jin ,  KIM, Yun Kyung

IPC: A01K67/027 ,  C12N15/85 ,  G01N33/50 ,  C12N5/073

Abstract: The present invention relates to a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.

Abstract translation: 本发明涉及用于筛选tau寡聚体形成的载体对，从载体对引入的小鼠胚胎，从小鼠胚胎获得的神经疾病的转基因模型小鼠，以及使用该载体对筛选τ寡聚物形成抑制剂候选物的方法 转基因模型小鼠。 更具体地，本发明提供了用于筛选tau寡聚体形成的载体对，其包含：第一载体，其包含第一tau基因，第一荧光蛋白基因和第一神经元特异性启动子; 以及第二载体，其包含第二tau基因，第二荧光蛋白基因和第二神经元特异性启动子，其中从第一荧光蛋白基因表达的蛋白和从第二荧光蛋白基因表达的蛋白相互结合以显示荧光 通过从第一个tau基因表达的蛋白质和从第二个tau基因表达的蛋白质之间的结合来实现。

公开(公告)号：EP4169909A1

公开(公告)日：2023-04-26

申请号：EP21825619.6

申请日：2021-06-18

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  LEE, Haeun ,  SON, Woo Seung ,  LEE, Hye Yeon

IPC: C07D237/04 ,  A61K31/50 ,  A61P25/28 ,  C07D237/14

Abstract: Provided are novel oxopyridazinyl-phenyl-carbonohydrazonoyl dicyanide compounds and uses thereof.

公开(公告)号：EP4169905A1

公开(公告)日：2023-04-26

申请号：EP21825235.1

申请日：2021-06-18

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  LEE, Haeun ,  SON, Woo Seung ,  LEE, Hye Yeon

IPC: C07D217/24 ,  A61K31/472 ,  A61K31/4184 ,  A61K31/428 ,  A61P25/28 ,  C07D235/26 ,  C07D471/04 ,  C07D277/68

Abstract: Provided are novel fused-heterocyclyl-carbonohydrazonoyl dicyanide compounds and uses thereof.

公开(公告)号：EP3901139A1

公开(公告)日：2021-10-27

申请号：EP18944116.5

申请日：2018-12-26

Applicant: Korea Institute of Science and Technology

Inventor： PAE, Ae Nim ,  KIM, Yun Kyung ,  LIM, Sang Min ,  LIM, Sungsu ,  SEONG, Jihye ,  LEE, Jae Wook ,  SONG, Ji Yeon ,  SHIN, Seulgi ,  JEONG, Hyean Jeong ,  SON, Woo Seung ,  LEE, Haeun ,  LIM, Da Mi ,  KIM, Seok Kyu ,  AHN, Jee Yun ,  KIM, Chae Won ,  LONDHE, Ashwini Machhindra ,  GOTINA, Lizaveta ,  KIM, Hyojin ,  LEE, Hye Yeon ,  KIM, Nam Gyung ,  CHA, Eunji ,  KIM, Kunhee ,  LIM, Ji Woong

IPC: C07D213/04 ,  A61K31/505 ,  A61K31/425 ,  C07D277/20 ,  C07D241/10 ,  C07D249/08 ,  C07D217/04 ,  C07D231/56 ,  C07D209/04 ,  C07D487/04

Abstract: The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.