公开(公告)号：JP2006209111A

公开(公告)日：2006-08-10

申请号：JP2006008728

申请日：2006-01-17

Applicant: Leica Microsystems Cms Gmbh ,  ライカ マイクロシステムス ツェーエムエス ゲーエムベーハー

Inventor： STORZ RAFAEL ,  ULRICH HEINRICH

IPC: G02B21/00 ,  G02B7/04

CPC classification number: G02B21/248 ,  G02B21/26

Abstract: PROBLEM TO BE SOLVED: To provide a microscope with an eye towards achieving a particularly simple structure.
SOLUTION: An objective (1) and/or an objective changer and/or an objective turret is/are coupled to an adjustment device (3) for positioning a specimen stage (6) in such a way that the position of the objective (1) and/or the objective changer and/or the objective turret can be adjusted by using the adjustment device (3).
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：为了使显微镜具有实现特别简单结构的目的。 解决方案：物镜（1）和/或物镜更换器和/或物镜转盘被耦合到调节装置（3），用于将样品台（6）定位成使得样品台（6）的位置 可以通过使用调节装置（3）来调节物镜（1）和/或物镜和/或物镜转塔。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2005173604A

公开(公告)日：2005-06-30

申请号：JP2004354160

申请日：2004-12-07

Applicant: Leica Microsystems Heidelberg Gmbh ,  ライカ ミクロジュステムス ハイデルベルク ゲーエムベーハー

Inventor： SEYFRIED VOLKER ,  STORZ RAFAEL

IPC: G02B21/06 ,  G01J3/44 ,  G02B21/00 ,  G02B21/16

CPC classification number: G01J3/4406 ,  G02B21/16

Abstract: PROBLEM TO BE SOLVED: To provide a method and a device for separating a plurality of different emission wavelengths by a simple means. SOLUTION: In the method for separating a plurality of different emission wavelengths in a scanning microscope (6) which is so configured that a specimen (4) is scanned with an illuminating light beam (10) which is guided onto the specimen (4) by a beam deflector and has a plurality of different excitation wavelengths (1, 2, 3), and emission light which is emitted from the specimen (4) and includes a plurality of emission wavelengths corresponding to the excitation wavelengths (1, 2, 3) is detected by at least one detector (5), the plurality of excitation wavelengths (1, 2, 3) are selectively applied to the illuminating light beam (10) during the scanning stage in accordance with a predefinable illumination scheme, and the detector is read out each time an excitation wavelength is applied, and detected signals are associated with the respective excitation wavelengths (1, 2, 3) by using the illumination scheme. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种通过简单的方法分离多个不同发射波长的方法和装置。 解决方案：在扫描显微镜（6）中分离多个不同发射波长的方法中，该扫描显微镜（6）被构造为用被引导到样本上的照明光束（10）扫描样本（4） 4），并且具有多个不同的激发波长（1,2,3）以及从所述检体（4）发射并且包括对应于所述激发波长（1,2）的多个发射波长的发射光 ，3）由至少一个检测器（5）检测到，根据预定义的照明方案，在扫描阶段期间，多个激发波长（1,2,3）被选择性地施加到照明光束（10），以及 每次施加激发波长时读出检测器，并且通过使用照明方案将检测信号与相应的激发波长（1,2,3）相关联。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2002098896A

公开(公告)日：2002-04-05

申请号：JP2001183692

申请日：2001-06-18

Applicant: LEICA MICROSYSTEMS

Inventor： STORZ RAFAEL ,  ENGELHARDT JOHANN

IPC: G02B23/26 ,  A61B1/06 ,  G02B6/02 ,  G02B6/122 ,  G02B6/255 ,  G02B19/00 ,  G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  G02B27/09 ,  H01S3/00 ,  H01S3/16

Abstract: PROBLEM TO BE SOLVED: To provide an illumination method and illumination device which are popularly usable, has adaptability, provide wavelength spectra of a wide band at high illumination density and avert interference as far as possible. SOLUTION: This method includes a step (1) of making a ray (13) of a laser (9) incident on a microstructure optical element (19) for causing the spectral diffusion of the ray, a step (3) of shaping the spectrally diffused ray (31) to an illumination ray (29) and a step (5) of directing the illumination ray (29) to an object (79).

公开(公告)号：JP2006113593A

公开(公告)日：2006-04-27

申请号：JP2005301271

申请日：2005-10-17

Applicant: Leica Microsystems Cms Gmbh ,  ライカ ミクロジュステムス ツェーエムエス ゲーエムベーハー

Inventor： BIRK HOLGER ,  STORZ RAFAEL ,  FEHRER DIRK-OLIVER ,  KRESS CLAUS

IPC: G02B21/28 ,  G02B26/10

Abstract: PROBLEM TO BE SOLVED: To provide a scanning microscope in which (configuring elements of) the microscope are efficiently cooled by a simply structured means. SOLUTION: Such a scanning microscope as a confocal scanning microscope is composed by including a scanning unit (1), a detecting unit (2), an electronic unit (3) for operating the scanning microscope, and a cooling unit for at least one configuring element of the scanning microscope. The cooling unit (4) is characterized in that the unit is composed so as to be operated with a liquid cooling medium. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种扫描显微镜，其中通过简单的结构化方式有效地冷却显微镜的（构成元件）。 解决方案：作为共聚焦扫描显微镜的这种扫描显微镜由包括扫描单元（1），检测单元（2），用于操作扫描显微镜的电子单元（3）和用于在扫描显示器 扫描显微镜的至少一个配置元件。 冷却单元（4）的特征在于，该单元构成为与液体冷却介质一起操作。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2002082286A

公开(公告)日：2002-03-22

申请号：JP2001183694

申请日：2001-06-18

Applicant: LEICA MICROSYSTEMS

Inventor： STORZ RAFAEL

IPC: G02B6/00 ,  G02B6/02 ,  G02B6/122 ,  G02B6/255 ,  G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  H01S3/00 ,  H01S3/16

Abstract: PROBLEM TO BE SOLVED: To provide an illuminator enabled to be universally used, easily operated having adaptability and capable of illuminating a target by light of a wide wavelength range. SOLUTION: A laser (3) and an optical element (13) of fine structure are integrated into a module.

公开(公告)号：JP2002055284A

公开(公告)日：2002-02-20

申请号：JP2001183690

申请日：2001-06-18

Applicant: LEICA MICROSYSTEMS

Inventor： BIRK HOLGER ,  STORZ RAFAEL

IPC: G02B5/00 ,  G02B6/00 ,  G02B6/02 ,  G02B6/122 ,  G02B6/255 ,  G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  H01S3/00 ,  H01S3/16

Abstract: PROBLEM TO BE SOLVED: To provide an illumination device of a scanning microscope which allows the use of a spectral range where addressing is heretofore infeasible. SOLUTION: An optical element (3) which spectrally diffuses the light produced by a laser (1) during the first passage is disposed between the laser (1) and an optical means (12).

公开(公告)号：JP2002055283A

公开(公告)日：2002-02-20

申请号：JP2001183689

申请日：2001-06-18

Applicant: LEICA MICROSYSTEMS

Inventor： STORZ RAFAEL ,  ENGELHARDT JOHANN

IPC: G02B5/00 ,  G02B6/02 ,  G02B6/122 ,  G02B6/255 ,  G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  H01S3/00 ,  H01S3/16

Abstract: PROBLEM TO BE SOLVED: To provide a scanning microscope which allows the inspection of a sample at various wavelengths and (or) in wavelength ranges and does not require the post adjustment of wavelength intrinsic component elements in an optical path at this time. SOLUTION: This scanning microscope is provided with an optical element 4 which produces at least partially spectrally diffusing illumination light within its illumination optical path 8. A beam splitter 11 which does not substantially depend upon polarized light and wavelength is positioned, fixed and arranged within the illumination optical path 8 and a detecting optical path 15.

公开(公告)号：JP2002048980A

公开(公告)日：2002-02-15

申请号：JP2001183695

申请日：2001-06-18

Applicant: LEICA MICROSYSTEMS

Inventor： STORZ RAFAEL ,  ENGELHARDT JOHANN

IPC: G02B5/00 ,  G02B5/04 ,  G02B5/18 ,  G02B5/22 ,  G02B6/02 ,  G02B6/122 ,  G02B6/255 ,  G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  H01S3/00 ,  H01S3/16

Abstract: PROBLEM TO BE SOLVED: To avoid illumination undesirable to a specimen in a scanning microscope. SOLUTION: A restricting means (16) to restrict the beam of a first wavelength is provided in a beam (15) whose wavelength is changed.

公开(公告)号：JP2001324679A

公开(公告)日：2001-11-22

申请号：JP2001100297

申请日：2001-03-30

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  HOFFMANN JUERGEN ,  STORZ RAFAEL ,  ULRICH HEINRICH ,  BEWERSDORF JOERG ,  BIRK HOLGER

IPC: G02B5/30 ,  G02B6/287 ,  G02B21/00 ,  G02B21/06 ,  G02B27/28 ,  G02F1/29 ,  G02F1/33

Abstract: PROBLEM TO BE SOLVED: To form a low output power laser beam source which can be utilized especially as a light source for a confocal scanning type microscopic method. SOLUTION: In this device for coupling beams from at least two laser beam sources 1 and 2 related to the confocal scanning type microscopic method, the beams from the laser beam sources 1 and 2 at least have nearly the same wavelength. The device is provided with at least a beam coupling device 11 coupling light beams by a system hardly having loss.

公开(公告)号：JP2001124997A

公开(公告)日：2001-05-11

申请号：JP2000280594

申请日：2000-09-14

Applicant: LEICA MICROSYSTEMS

Inventor： HARTMANN NICOLE ,  STORZ RAFAEL

IPC: G02B5/30 ,  G02B21/00

Abstract: PROBLEM TO BE SOLVED: To simplify the structure of a known device and to enable expansion of detection variation which has been possible thus far. SOLUTION: This device is equipped with at least one spectrum selective element (2), which projects an exciting light (3) of a light source (1) onto a microscope (4), cuts off at least part of the exciting light scattered and reflected by an object from a detection optical path (5) and will not cut off detection light originating from the object, and can be matched with the wavelength of the exciting light of the light source (1). An optical device on the optical path of a laser scanning microscope has another optical member (8) arranged following the element (2) and is featured by the detection of dispersing and/or refracting properties of the detection light.