公开(公告)号：AU2019201088B2

公开(公告)日：2020-07-09

申请号：AU2019201088

申请日：2019-02-15

Applicant: OCULEVE INC

Inventor： ACKERMANN DOUGLAS MICHAEL ,  LOUDIN JAMES DONALD ,  WARDLE JOHN ,  BALDWIN JARREN ARMOND ,  HAMILTON DANIEL N ,  KUZMA JANUSZ ,  STIVERS CHRISTOPHER WILLIAM

IPC: A61N1/36 ,  A61F7/12 ,  A61H1/00 ,  A61M31/00

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

公开(公告)号：CA2940533A1

公开(公告)日：2015-09-03

申请号：CA2940533

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61N1/05 ,  A61N1/36 ,  H01B1/12

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：AU2014253754C1

公开(公告)日：2015-07-30

申请号：AU2014253754

申请日：2014-04-18

Applicant: OCULEVE INC

Inventor： ACKERMANN DOUGLAS MICHAEL ,  LOUDIN JAMES DONALD ,  WARDLE JOHN ,  BALDWIN JARREN ARMOND ,  HAMILTON DANIEL N ,  KUZMA JANUSZ ,  STIVERS CHRISTOPHER WILLIAM

IPC: A61N1/18 ,  A61F7/12 ,  A61H1/00 ,  A61M31/00 ,  A61N1/30 ,  A61N1/36 ,  A61N1/372

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

公开(公告)号：EP3110405A4

公开(公告)日：2017-10-18

申请号：EP15754827

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61K9/14 ,  C08F220/54 ,  C08F222/10 ,  C08F226/10 ,  C08F230/08

CPC classification number: A61N1/0546 ,  A61N1/0456 ,  A61N1/0496 ,  A61N1/36014 ,  C08F220/54 ,  C08F230/08 ,  H01B1/125 ,  Y10T29/49826 ,  Y10T29/49885 ,  C08F226/10 ,  C08F220/20 ,  C08F2222/1013 ,  C08F2230/085

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：NZ745920A

公开(公告)日：2020-01-31

申请号：NZ74592014

申请日：2014-04-18

Applicant: OCULEVE INC

Inventor： ACKERMANN DOUGLAS ,  LOUDIN JAMES ,  WARDLE JOHN ,  BALDWIN JARREN ,  HAMILTON DANIEL ,  KUZMA JANUSZ ,  STIVERS CHRISTOPHER

IPC: A61N1/18 ,  A61N1/30 ,  A61N1/36 ,  A61N1/372

Abstract: A system or device for stimulating nasal tissue of a subject, comprising: a stimulator comprising a stimulator probe comprising a nasal insertion prong; and a handheld stimulator body comprising a rechargeable power source and a control subsystem to control a stimulus to be delivered to the subject via the nasal insertion prong; and a base station to recharge the rechargeable power source, comprising one or more electrical contacts configured to connect to the stimulator body, wherein the stimulator probe is releasably connected to the stimulator body, and wherein the stimulator comprises a disabling mechanism that prevents stimulus delivery to the subject after at least one of a predetermined time from attachment of the stimulator probe, a predetermined number of treatment sessions, a predetermined duration of stimulus delivery, or reconnection of the stimulator probe to the stimulator body after being disconnected from the stimulator body. The disabling configuration prevents re-use of probes that may be unsanitary.

公开(公告)号：AU2019201088A1

公开(公告)日：2019-03-07

申请号：AU2019201088

申请日：2019-02-15

Applicant: OCULEVE INC

Inventor： ACKERMANN DOUGLAS MICHAEL ,  LOUDIN JAMES DONALD ,  WARDLE JOHN ,  BALDWIN JARREN ARMOND ,  HAMILTON DANIEL N ,  KUZMA JANUSZ ,  STIVERS CHRISTOPHER WILLIAM

IPC: A61N1/36 ,  A61F7/12 ,  A61H1/00 ,  A61M31/00

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

公开(公告)号：NZ704579A

公开(公告)日：2018-10-26

申请号：NZ70457914

申请日：2014-04-18

Applicant: OCULEVE INC

Inventor： ACKERMANN DOUGLAS ,  LOUDIN JAMES ,  WARDLE JOHN ,  BALDWIN JARREN ,  HAMILTON DANIEL ,  KUZMA JANUSZ ,  STIVERS CHRISTOPHER

IPC: A61N1/18 ,  A61N1/30 ,  A61N1/36 ,  A61N1/372

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

公开(公告)号：ZA201605563B

公开(公告)日：2017-09-27

申请号：ZA201605563

申请日：2016-08-11

Applicant: OCULEVE INC

Inventor： CHRIST F RICHARD ,  CHRIST MARIE DVORAK ,  DORAISWAMY ANAND ,  STIVERS CHRISTOPHER WILLIAM ,  WARDLE JOHN ,  GUPTA AMITAVA ,  LOUDIN JAMES DONALD

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：MX2016011118A

公开(公告)日：2016-12-05

申请号：MX2016011118

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： GUPTA AMITAVA ,  WARDLE JOHN ,  JAMES DONALD LOUDIN ,  CHRISTOPHER WILLIAM STIVERS ,  ANAND DORAISWAMY ,  MARIE DVORAK CHRIST ,  F RICHARD CHRIST

IPC: A61K9/00 ,  A61K9/14

Abstract: En la presente se describen formulaciones de polímeros para facilitar la estimulación eléctrica de tejido nasal o sinusal. Las formulaciones de polímeros pueden ser tipos de hidrogel que se preparan mediante un proceso de reticulación UV. Los tipos de hidrogel se pueden incluir como un componente de dispositivos estimuladores nasales que estimulan de forma eléctrica la glándula lagrimal para mejorar la producción de lágrimas y tratar el ojo seco. De manera adicional, se describen en la presente los dispositivos y métodos para elaborar los estimuladores nasales, que incluyen moldear el hidrogel.

公开(公告)号：CA2965186A1

公开(公告)日：2016-04-28

申请号：CA2965186

申请日：2015-10-22

Applicant: OCULEVE INC

Inventor： FRANKE MANFRED ,  LOUDIN JAMES DONALD ,  WARDLE JOHN ,  HOLDBROOK MARK JEFFREY

IPC: A61N1/36

Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.