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公开(公告)号：WO1995011019A1
公开(公告)日：1995-04-27
申请号：PCT/US1994012013
申请日：1994-10-20
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: A61K31/195
CPC classification number: A61K31/195 , A23L2/52 , A23L2/68 , A23L33/175 , A61K31/19 , A61K2300/00
Abstract: The present invention relates to an ingestible composition designed to combine enhancement of physical performance with the reduction of body fat. More specifically, the present invention is directed to ingestible compositions comprising glutamine in an amount effective to induce a growth hormone response in the consumer, i.e. an increase in the blood levels of growth hormone in the body. The performance enhancing beverage compositions according to the present invention contain from about 1.0 to about 4.0 g of glutamine per 473 milliliters. The performance enhancing foodstuff compositions of the present invention contain at least about 1 g of glutamine.
Abstract translation: 本发明涉及一种旨在将物理性能的提高与减少身体脂肪相结合的可摄取组合物。 更具体地，本发明涉及含有有效诱导消费者生长激素反应的量的谷氨酰胺的可摄入组合物，即体内生长激素的血液水平的增加。 根据本发明的性能提高饮料组合物每473毫升含有约1.0至约4.0g谷氨酰胺。 本发明的增强性能的食品组合物含有至少约1g谷氨酰胺。
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公开(公告)号：WO1994008012A1
公开(公告)日：1994-04-14
申请号：PCT/US1993009426
申请日：1993-10-04
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: C12N15/31
CPC classification number: C12N15/81 , C07K14/39 , C07K14/395 , C12N9/90 , C12P21/02
Abstract: The present invention is directed to methods for increasing secretion of an overexpressed gene product present in a host cell, by inducing expression of chaperone proteins within the host cell.
Abstract translation: 本发明涉及通过在宿主细胞内诱导分子伴侣蛋白的表达来增加存在于宿主细胞中的过表达基因产物的分泌的方法。
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公开(公告)号：WO1994007484A1
公开(公告)日：1994-04-14
申请号：PCT/US1993009293
申请日：1993-10-01
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: A61K31/335
CPC classification number: A23D7/00 , A61K9/0019 , A61K9/107 , A61K31/335 , A61K47/06 , A61K47/44
Abstract: Compositions of matter are provided comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof solubilized in a pharmaceutically acceptable carrier comprising an oil having a dipole moment of between about 0.5 Debyes and about 2.0 Debyes, and preferably between about 1.6 and about 1.7 Debyes. Oils from marine organisms having an ether lipid as a major component thereof are preferred. Methods of solubilizing taxol or tumor-active taxol analogs in the pharmaceutically acceptable oils of this invention are provided comprising forming a first solution by dissolving taxol in a preliminary solvent such as an anhydrous alcohol, then adding sufficient oil to solubilize said first solution. Taxol-in-oil solutions are used to prepare oil-in-water emulsions and other dosage forms for pharmaceutical use in antitumor therapy by means known to the art using known surfactants.
Abstract translation: 提供的物质组合物包含药学上有效量的紫杉醇或其可溶于药学上可接受的载体的肿瘤活性类似物，其包含偶极矩在约0.5德比和约2.0德比之间，优选约1.6至约1.7的油 德拜。 具有醚类脂质作为主要成分的海洋生物的油是优选的。 提供了将紫杉醇或肿瘤活性紫杉酚类似物溶解在本发明的药学上可接受的油中的方法，包括通过将紫杉醇溶解在诸如无水醇的预溶剂中形成第一溶液，然后加入足够的油来溶解所述第一溶液。 盐酸紫杉醇溶液用于制备水包油乳剂和用于药物用于抗肿瘤治疗的其它剂型，其通过本领域已知的方法使用已知的表面活性剂。
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14.发明申请TRIVALENT SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING STEREOSPECIFIC ALKYLPHOSPHONATES AND ARYLPHOSPHONATES 审中-公开含有立体烷基磷酸酯和芳基磷酸酯的寡核苷酸的多态合成
公开(公告)号：WO1994000472A2
公开(公告)日：1994-01-06
申请号：PCT/US1993006251
申请日：1993-06-30
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: C07H21/00
CPC classification number: C12N15/113 , C07H21/00
Abstract: The present invention provides a method for making R stereospecific alkyl- and aryl-phosphonate linkages between nucleotides. These methods can be used for automated synthesis of oligonucleotides having sequential R stereospecific alkyl- and aryl-phosphonate linkages. The present invention is also directed to the oligonucleotides having several sequential R phosphonate linkages which were produced by the subject methods. Moreover, the present invention provides methods for using the subject oligonucleotides, including methods for regulating the biosynthesis of a DNA, an RNA or a protein and methods for detecting and isolating complementary nucleic acid targets.
Abstract translation: 本发明提供了在核苷酸之间制备R立体特异性烷基 - 和芳基 - 膦酸酯键的方法。 这些方法可用于自动合成具有顺序R立体特异性烷基 - 和芳基 - 膦酸酯键的寡核苷酸。 本发明还涉及通过本发明方法制备的具有多个连续的R膦酸酯键的寡核苷酸。 此外，本发明提供了使用本发明的寡核苷酸的方法，包括调节DNA，RNA或蛋白质的生物合成的方法以及用于检测和分离互补核酸靶的方法。
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公开(公告)号：WO1993025243A3
公开(公告)日：1993-12-23
申请号：PCT/US1993005532
申请日：1993-06-10
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. , FERNANDO, Quintus , INOUE, Michiko , INOUE, Motomichi
IPC: A61K49/00
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Patent Agency Ranking16.发明申请BIS(CARBAMOYLPIPERIDYL)ALKYLENES AS PLATELET AGGREGATION INHIBITORY AGENTS 审中-公开BIS（CARBAMOYLPIPERIDYL）烷基酯作为片剂聚集抑制剂
公开(公告)号：WO1993012087A1
公开(公告)日：1993-06-24
申请号：PCT/US1992010822
申请日：1992-12-16
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: C07D211/60
CPC classification number: C07D211/60
Abstract: The present invention relates to substantially pure stereoisomers of a compound of formula (I) wherein n1 and n2 are the same or different and are 1 or 2; X is alkyl (C1-C10), aryl (C6-C10) or aralkyl (C7-C12); and wherein R, R1, R2 and R3 are the same or different and are chosen from H, alkyl (C1-C10), aryl (C6-C10), aralkyl (C7-C12), or a heterocyclic group, and addition salts thereof with pharmaceutically acceptable acids. The invention also relates to a method for the inhibition of blood platelet aggregation in a blood supply comprising administering to said blood supply a blood platelet aggregation inhibiting amount of the compounds of the present invention.
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公开(公告)号：WO1992017484A1
公开(公告)日：1992-10-15
申请号：PCT/US1992002480
申请日：1992-03-26
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: C07H0
CPC classification number: A61K31/70 , A61K38/00 , C07H21/00 , C12N15/113 , C12N15/1135 , C12N2310/152 , C12N2310/3183 , C12N2310/321 , C12N2310/53 , C12Q1/6813 , C12Q1/6839 , C12Q1/6886 , C12Q1/703 , C12N2310/3521
Abstract: The present invention provides single-stranded circular oligonucleotides each with a parallel binding (P) domain and an anti-parallel binding (AP) domain separated from each other by loop domains. Each P and AP domain has sufficient complementarity to bind to one strand of a defined nucleic acid target wherein the P domain binds in a parallel manner to the target and the AP domain binds in an anti-parallel manner to the target. Moreover, the present single-stranded circular oligonucleotides can bind to both single-stranded and double-stranded target nucleic acids. The present invention also provides methods of using these oligonucleotides as well as pharmaceutical compositions containing these oligonucleotides.
Abstract translation: 本发明提供了单链的环状寡核苷酸，每一个具有平行结合（P）结构域和通过环结构域彼此分离的反平行结合（AP）结构域。 每个P和AP结构域具有足够的互补性，以结合定义的核酸靶的一条链，其中P结构域以平行的方式与靶结合，并且AP结构域以反平行方式与靶结合。 此外，本发明的单链环状寡核苷酸可以结合单链和双链靶核酸。 本发明还提供了使用这些寡核苷酸的方法以及含有这些寡核苷酸的药物组合物。
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公开(公告)号：WO1992006989A1
公开(公告)日：1992-04-30
申请号：PCT/US1991007280
申请日：1991-10-04
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. , VAFAI, Abbas
IPC: C07H15/12
CPC classification number: C07K14/005 , A61K39/00 , C07K16/088 , C12N2710/16722 , G01N33/56983
Abstract: The present invention relates to the construction of a recombinant plasmid which is capable of expressing a secretory truncated glycoprotein (Tgp) of Varicella-zoster virus (BZV) in mammalian cells. The secretory Tgp of the present invention contains at least one epitope capable of inducing antibody response. the present invention comtemplates the production and utilization of this secretory Tgp in a vaccine against chickenpox and/or shingles. The present invention is also directed towards the use of the secretory Tgp in diagnostic assays for detection of VZV. The present invention is also directed to first antibodies specific to secretory Tgp and to second antibodies specific to the first antibodies. These second antibodies are also useful in diagnostic assays for VZV.
Abstract translation: 本发明涉及能够在哺乳动物细胞中表达水痘带状疱疹病毒（BZV）的分泌截短的糖蛋白（Tgp）的重组质粒的构建。 本发明的分泌Tgp含有至少一种能诱导抗体应答的表位。 本发明考察了在针对水痘和/或带状疱疹的疫苗中该分泌型Tgp的产生和利用。 本发明还涉及在用于检测VZV的诊断测定中使用分泌型Tgp。 本发明还涉及对分泌型Tgp特异性的第一抗体和针对第一抗体特异性的第二抗体。 这些第二抗体也可用于VZV的诊断测定。
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19.发明申请2-CARBOXALDEHYDE SUBSTITUTED QUINOLINE REAGENTS FOR THE DETECTION OF PRIMARY AMINO GROUPS 审中-公开用于检测主要氨基酸组合物的二羧甲基取代的喹啉试剂
公开(公告)号：WO1992006961A1
公开(公告)日：1992-04-30
申请号：PCT/US1991007517
申请日：1991-10-11
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. , NOVOTNY, Milos, V. , WIESLER, Donald , LIU, Jinping , HSIEH, You-Zung
IPC: C07D215/16
CPC classification number: C07D405/06 , C07D215/14 , C07D471/04 , G01N33/52 , G01N33/6809 , Y10T436/173845 , Y10T436/200833
Abstract: The invention is directed to 3-aroyl-2 carboxaldehyde-quinolines, processes for making them, and their use in detection and quantification of primary amino groups in various biological and chemical applications. Thus the measurement, isolation and identification of compounds with primary amino groups such as amino acids, proteins, etc. can be carried out. Processes for the preparation of these reagents and certain compounds produced therefrom are also desired.
Abstract translation: 本发明涉及3-芳酰基-2-甲醛 - 喹啉，其制备方法，以及它们在各种生物和化学应用中检测和定量伯氨基的用途。 因此，可以进行具有伯氨基，例如氨基酸，蛋白质等的化合物的测量，分离和鉴定。 也希望制备这些试剂和由其制备的某些化合物的方法。
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公开(公告)号：WO1991015437A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002029
申请日：1991-03-26
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. , MESSING, Gary, L. , SPROSON, Derek, W. , ZHANG, Shi, Chang
IPC: C04B35/00
CPC classification number: C04B20/0056 , C04B35/6225
Abstract: Discontinuous, discrete ceramic fibers are prepared by atomizing a viscous sol or solution of a precursor of a metal oxide into a heated zone where the discontinuous discrete fibers are formed. Subsequent calcination of the fibers provides discontinuous discrete metal oxide ceramic fibers.
Abstract translation: 通过将金属氧化物前体的粘性溶胶或溶液雾化到形成不连续离散纤维的加热区中来制备不连续的离散陶瓷纤维。 随后的纤维煅烧提供不连续的离散金属氧化物陶瓷纤维。
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