公开(公告)号：AT301635T

公开(公告)日：2005-08-15

申请号：AT98402963

申请日：1998-11-27

Applicant: SERVIER LAB

Inventor： LEFOULON FRANCOIS ,  DEMUYNCK LUC ,  LESIEUR DANIEL ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: A61K31/00 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P25/20 ,  A61P43/00 ,  C07C233/05 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C233/31 ,  C07C233/36 ,  C07C233/47 ,  C07C233/58 ,  C07C233/60 ,  C07C255/66 ,  C07C275/24 ,  C07C309/65 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C327/42 ,  C07C335/06 ,  C07D213/56 ,  C07D233/60 ,  C07D307/12 ,  C07D307/52 ,  C07D307/54 ,  C07D333/16 ,  C07D333/20

Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.

公开(公告)号：NZ532221A

公开(公告)日：2005-07-29

申请号：NZ53222104

申请日：2004-04-08

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  ENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24 ,  A61K31/4045 ,  A61P9/10 ,  A61P25/14 ,  A61P25/18 ,  C07D221/04

Abstract: Described is a compound of formula (I): wherein n is l, 2 or 3, A represents a group -NR-C(=Z)-R', -C(=Z)-N(R)-R', or a group -NR-C(=Z)-N(R')-R", wherein: Z represents a S or O; R and R", which may be identical or different, each represents a H or alkyl group; R' represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl or heteroaryl-alkyl group; X represents N or N-R1 wherein R1 represents a H or alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aroyl, aryl-alkyl, heteroaryl, heteroaroyl or heteroaryl-alkyl group; R2 represents an alkoxy, cycloalkoxy or cycloalkyl-alkoxy group Provided are processes for the preparation of compounds if the formula (I) and descriptions of their use in the preparation of medicaments for treatment of disorders of the melatoninergic system.

公开(公告)号：HK1067121A1

公开(公告)日：2005-04-01

申请号：HK04110086

申请日：2004-12-21

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K20090101 ,  A61K31/472 ,  A61P20090101 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D20090101 ,  C07D217/16 ,  C07D217/24

公开(公告)号：FR2853649A1

公开(公告)日：2004-10-15

申请号：FR0304381

申请日：2003-04-09

Applicant: SERVIER LAB

Inventor： POISSONNIER DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24

公开(公告)号：NO20041313L

公开(公告)日：2004-10-11

申请号：NO20041313

申请日：2004-03-30

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  AUDINOT VALERIE ,  BENNEJEAN CAROLINE ,  WALLEZ VALERIE ,  RENARD PIERRE ,  YOUS SAID ,  DELAGRANGE PHILIPPE ,  POISSONNIER-DURIEUX SOPHIE ,  GASNEREAU ANNE ,  BOUTON JEAN ALBERT

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24 ,  C07D217/22 ,  A61K31/4353

公开(公告)号：EA004676B1

公开(公告)日：2004-06-24

申请号：EA200200810

申请日：2001-02-01

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC-DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4353

Abstract: Соединенияформулы (I)вкоторойХ представляетсобойатомкислородаилиатомсеры, илигруппуСН, илиRи Rпредставляютсобойатомводородаилигруппу, какуказанов описании,Апредставляетсобойалкиленовуюцепочку, какуказанов описании,Вимеетзначение, какуказанов описании,Rи Rпредставляютсобойатомводородаилигруппу, какуказанов описании,D представляетсобойнеобязательнозамещенноебензольное, необязательнозамещенноепиразиновое, необязательнозамещенноепиримидиновоеилинеобязательнозамещенноепиридазиновоеядро. Лекарственныепрепараты.

公开(公告)号：FR2830012B1

公开(公告)日：2003-10-31

申请号：FR0112205

申请日：2001-09-21

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC DELMAS ELODIE ,  BENNEJEAN CAROLINE ,  CHAVATTE PHILIPPE ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  RENARD PIERRE

IPC: A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/10 ,  A61P35/00 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/428

公开(公告)号：PT1252150E

公开(公告)日：2003-09-30

申请号：PT01904021

申请日：2001-02-01

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  LESIEUR DANIEL ,  DACQUET CATHERINE ,  GUILLAUMET GERALD ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  LEVENS NIGEL ,  RENARD PIERRE ,  BLANC-DELMAS ELODIE ,  BOUTIN JEAN ALBERT

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4353

Abstract: Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH 2 or R 1 and R 2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R 3 and R 4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.

公开(公告)号：PT1038863E

公开(公告)日：2003-09-30

申请号：PT00400813

申请日：2000-03-24

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  RENARD PIERRE ,  LEFOULON FRANCOIS ,  GUILLAUMET GERALD ,  DELAGRANGE PHILIPPE ,  VIAUD MARIE-CLAUDE ,  BENNEJEAN CAROLINE ,  YOUS SAID ,  DESCAMPS-FRANCOIS CAROLE

IPC: C07D339/08 ,  A61K31/16 ,  A61K31/165 ,  A61K31/33 ,  A61K31/341 ,  A61K31/343 ,  A61K31/381 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P15/18 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  B01J31/24 ,  C07B61/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/20 ,  C07C233/36 ,  C07C233/60 ,  C07C233/73 ,  C07C235/34 ,  C07C271/16 ,  C07C275/24 ,  C07C319/14 ,  C07C323/42 ,  C07D209/14 ,  C07D209/16 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D311/58 ,  C07D319/20 ,  C07D333/58 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds (I) selected from alkylenedioxybisnaphthalene derivatives and related compounds are new. Compounds of formula (I) other than diethyl 2-acetylamino-2-(5-(3-(2-acetylamino-3-ethoxy-2-ethoxycarbonyl-3-oxopr opyl)-1H-indol-5-ylmethyl)-1H-indol-3-ylmethyl)malonate and N-(2-(5-(3-(2-acetylaminoethyl)-1H-indol-5-ylmethyl)-1H-indol-3-yl)eth yl)acetamide are new. A = NR -C(Q)-R , NR -C(Q)-NR R or C(Q)-NR R ; Q = O or S; R - R = H or R; or NR R = 1-piperazinyl, piperidino or pyrrolidino; R = optionally Q'-substituted 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl or (3-8C cycloalkyl)-(1-6C alkyl); 1-6C polyhaloalkyl; or optionally Q-substituted aryl, aryl(1-6C alkyl), aryl(2-6C alkenyl), heteroaryl, heteroaryl-(1-6C alkyl) or heteroaryl-(2-6C alkenyl); B = NR -C(Q)-R , NR -C(Q)-NR R , C(Q)-NR R , C(Q)-OR , NR -C(Q)-OR or NR R ; G1, G3 = 1-4C alkylene optionally substituted by one or more of OH, COOH, CHO, R, OR, C(O)OR or C(O)R; Cy = a group of formula (i) in which G2 is attached to the benzene ring and G1 or G3 is attached to the other ring, or a group of formula (ii) in which G2 is attached to the D ring and G1 or G3 is attached to the other ring: X, Y' = S, O, C, CH or CH2; R = H, halogen, CF3, OH, COOH, CHO, NH2, NHR, NRR', NHC(O)R, C(O)NHR, R, OR, C(O)R or COOR; R' = R; Z' = S, O, CH, CH2, NH, NSO2-phenyl or NR; D' = a benzene or pyridine ring; G2 = an optionally substituted W1(CH2)nW2(CH2)mW3 group containing no adjacent heteroatoms; W1-W3 = bond, O, S, CH2, CHR, NH or NR; n, m = 0 - 6; Q' = one or more of OH, 1-6C alkoxy, 1-6C polyhaloalkyl, NH2, 1-6C alkylamino, di(1-6C alkyl)amino and halogen; aryl = naphthyl, phenyl or biphenylyl; heteroaryl = a saturated or unsaturated mono- or bicyclic group containing 5-10 C atoms and 1-3 heteroatoms selected from N, S and O; and Q = OH, COOH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CHO, CN, NO2, NH2, 1-6C alkylamino, di(1-6C alkyl)amino and halogen. Independent claims are also included for the following: (1) a process for preparing (I); and (2) compounds of formula (II) other than N-(2-(5-(2-hydroxyethoxy)-1H-indol-3-yl)ethyl)acetamide. W4 = O, S, NH or NR; and E' = OH or halogen; provided that W4-(CH2)n-W2-(CH2)m is not oxyalkylene when Cy is naphthylene and G1-A is (CH2)2-NR CQR or (CH2)2-NR CQNR R .

公开(公告)号：SK4692003A3

公开(公告)日：2003-08-05

申请号：SK4692003

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： DESCAMPS-FRANCOIS CAROLE ,  YOUS SAID ,  LESIEUR DANIEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  DA COSTA HERVE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: C07D333/58 ,  A61K31/235 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/28 ,  A61P35/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/60 ,  C07D209/08 ,  C07D209/20 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D471/04 ,  C07C209/16 ,  A61K31/165 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40

Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR' group, or a (C 1 -C 6 )alkyl group substituted by a COOR, CONRR' or OR group, G 1 represents a -X'-(CH 2 ) n -X-(CH 2 ) m -X''- chain wherein X, X', X'', n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G 2 represents an alkylene chain as defined in the description, and A represents a NRCOR', NRCSR', CONRR', CSNRR', NRCONR'R'' or NRCSNR'R'' group.