公开(公告)号：AU783908B2

公开(公告)日：2005-12-22

申请号：AU9744201

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：DE60105746T2

公开(公告)日：2005-10-06

申请号：DE60105746

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：EA004254B1

公开(公告)日：2004-02-26

申请号：EA200101230

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04 ,  A61K31/443 ,  A61K31/4355

Abstract: Соединенияформулы (I)вкоторой Rпредставляетсобойатомводорода, атомгалогена, алкильнуюгруппуилиалкоксигруппу, Хпредставляетсобойатомкислорода, атомсерыилигруппу NR, вкоторой R представляетсобойатомводородаилиалкильнуюгруппу, Апредставляетсобойлюбуюизгрупп, описанныхв описании, ихизомеры, иихаддитивныесолис фармацевтическиприемлемойкислотойилиоснованием. Лекарственныепрепараты.

公开(公告)号：DE60002395D1

公开(公告)日：2003-06-05

申请号：DE60002395

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle

公开(公告)号：ZA200110517B

公开(公告)日：2002-07-11

申请号：ZA200110517

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04 ,  C07D ,  A61K

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：AT212634T

公开(公告)日：2002-02-15

申请号：AT98402806

申请日：1998-11-13

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  REMOND GEORGES ,  PALADINO JOSEPH ,  ATASSI GHANEM ,  PIERRE ALAIN ,  TUCKER GORDON ,  BONNET JACQUELINE ,  SABATINI MASSIMO

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/437 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D471/04 ,  A61K31/44 ,  C07D221/00 ,  C07D209/00

Abstract: Tetrahydro carboline derivatives of formula (I) and their preparation from D-tryptophan derivatives. Tetrahydrocarboline derivatives of formula (I) their isomers and their salts m = 1, 2,3, or 4; n and p = 0, 1, 2, 3, or 4; X = O, S, or a simple bond; R1 = H, halogen, 1-6C alkyl or trihaloalkyl, OH, 1-6C alkoxy or trihaloalkoxy; R2, R3, and R4 = H or 1-6C alkyl; R5 = H, halogen,1-6C alkoxy, aryloxy or heteroaryloxy; R6, R7, and R8 = H, 1-6C alkyl, or R6 with N and R7 or R8 form a heterocycle; R9 = -SO3H, -COOR10, -CO-NR11R12, or -NR13R14; R10 = H or 1-6C alkyl; R11 and R12 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom; R13 and R14 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom

公开(公告)号：PL345101A1

公开(公告)日：2001-12-03

申请号：PL34510199

申请日：1999-06-29

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  CHOLLET ANNE-MARIE ,  LE DIGUARHER THIERRY ,  ATASSI GHANEM ,  BONNET JACQUELINE ,  PIERRE ALAIN ,  SABATINI MASSIMO ,  TUCKER GORDON ,  GUILBAUD NICOLAS

IPC: C07D253/04 ,  A61K31/18 ,  A61K31/197 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/517 ,  A61K31/53 ,  A61K31/535 ,  A61K31/536 ,  A61K31/537 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C233/82 ,  C07C233/83 ,  C07C259/10 ,  C07C311/29 ,  C07D209/48 ,  C07D209/66 ,  C07D231/22 ,  C07D233/72 ,  C07D233/74 ,  C07D237/32 ,  C07D239/96 ,  C07D253/08 ,  C07D265/06 ,  C07D265/16 ,  C07D275/04 ,  C07D275/06 ,  C07D277/20 ,  C07D277/34 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D471/04 ,  A61K31/40 ,  C07D221/14 ,  C07D263/44 ,  C07D265/26

公开(公告)号：SI1217002T1

公开(公告)日：2004-12-31

申请号：SI200130194

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：AR035409A1

公开(公告)日：2004-05-26

申请号：ARP010105928

申请日：2001-12-20

Applicant: SERVIER LAB

Inventor： TUCKER GORDON ,  DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04

Abstract: Compuestos inhibidores de metalo proteasas de fórmula (1): en la cual R1 representa un átomo de halógeno, un grupo alquilo (C1-6) lineal o ramificado o un grupo alcoxi (C1-6) lineal o ramificado, X representa un átomo de oxígeno, un átomo de azufre o un grupo NR en el cual R representa un átomo de hidrógeno o un grupo alquilo (C1-6) lineal o ramificado, A representa cualquiera de los grupos (2), en el cual Ra representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo (C1-6) lineal o ramificado; (3) en el cual Rb, Rc son idénticos o diferentes, representa un átomo de hidrógeno o un grupo alquilo (C1-6) lineal o ramificado, y n es 0, 1 o 2; o (4), sus isómeros, N-óxidos y sus sales de adición con un ácido o con una base farmacéuticamente aceptable. Estos compuestos han demostrado ser más poderosos que aquellos descriptos en la literatura, que los hace por lo tanto potencialmente útiles para el tratamiento de los cánceres de las enfermedades reumáticas, como la artrosis y la artritis reumatoide, de la arteriosclerosis etc. Su procedimiento de preparación y las composiciones farmacéuticas que los contienen.

公开(公告)号：ES2198262T3

公开(公告)日：2004-02-01

申请号：ES00401864

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle