公开(公告)号：FI115769B

公开(公告)日：2005-07-15

申请号：FI955024

申请日：1995-10-20

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  REMOND GEORGES ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  CANET EMMANUEL ,  BIRRELL GRAHAM

IPC: A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04

公开(公告)号：ES2202775T3

公开(公告)日：2004-04-01

申请号：ES98402926

申请日：1998-11-25

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  TORDJMAN CHARLES

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/72 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D487/04 ,  C07D491/16

Abstract: Compounds of formula (I): wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C1-C6)-acyl, R1 and R2, which may be identical or different, each represents independently of the other aryl, heteroaryl, or (C5-C7)-cycloalkyl, or one of those groups optionally substituted, A, together with the atoms in common with the pyrrole, represents saturated or unsaturated, monocyclic or bicyclic (C3-C12)-cycloalkyl, or a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen, or 7-oxabicyclo[2.2.1]heptane, or one of those groups optionally substituted, their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, pharmaceutical compositions thereof, and use thereof as medicaments.

公开(公告)号：AU770168B2

公开(公告)日：2004-02-12

申请号：AU4378400

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SBATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle

公开(公告)号：DE60002395D1

公开(公告)日：2003-06-05

申请号：DE60002395

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle

公开(公告)号：AT212634T

公开(公告)日：2002-02-15

申请号：AT98402806

申请日：1998-11-13

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  REMOND GEORGES ,  PALADINO JOSEPH ,  ATASSI GHANEM ,  PIERRE ALAIN ,  TUCKER GORDON ,  BONNET JACQUELINE ,  SABATINI MASSIMO

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/437 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D471/04 ,  A61K31/44 ,  C07D221/00 ,  C07D209/00

Abstract: Tetrahydro carboline derivatives of formula (I) and their preparation from D-tryptophan derivatives. Tetrahydrocarboline derivatives of formula (I) their isomers and their salts m = 1, 2,3, or 4; n and p = 0, 1, 2, 3, or 4; X = O, S, or a simple bond; R1 = H, halogen, 1-6C alkyl or trihaloalkyl, OH, 1-6C alkoxy or trihaloalkoxy; R2, R3, and R4 = H or 1-6C alkyl; R5 = H, halogen,1-6C alkoxy, aryloxy or heteroaryloxy; R6, R7, and R8 = H, 1-6C alkyl, or R6 with N and R7 or R8 form a heterocycle; R9 = -SO3H, -COOR10, -CO-NR11R12, or -NR13R14; R10 = H or 1-6C alkyl; R11 and R12 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom; R13 and R14 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom

公开(公告)号：PL345101A1

公开(公告)日：2001-12-03

申请号：PL34510199

申请日：1999-06-29

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  CHOLLET ANNE-MARIE ,  LE DIGUARHER THIERRY ,  ATASSI GHANEM ,  BONNET JACQUELINE ,  PIERRE ALAIN ,  SABATINI MASSIMO ,  TUCKER GORDON ,  GUILBAUD NICOLAS

IPC: C07D253/04 ,  A61K31/18 ,  A61K31/197 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/517 ,  A61K31/53 ,  A61K31/535 ,  A61K31/536 ,  A61K31/537 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C233/82 ,  C07C233/83 ,  C07C259/10 ,  C07C311/29 ,  C07D209/48 ,  C07D209/66 ,  C07D231/22 ,  C07D233/72 ,  C07D233/74 ,  C07D237/32 ,  C07D239/96 ,  C07D253/08 ,  C07D265/06 ,  C07D265/16 ,  C07D275/04 ,  C07D275/06 ,  C07D277/20 ,  C07D277/34 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D471/04 ,  A61K31/40 ,  C07D221/14 ,  C07D263/44 ,  C07D265/26

公开(公告)号：AU9416598A

公开(公告)日：1999-06-17

申请号：AU9416598

申请日：1998-11-26

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  TORDJMAN CHARLES ,  BONNET JACQUELINE ,  PORTEVIN BERNARD

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/72 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D487/04 ,  C07D491/16

Abstract: Compounds of formula (I): wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C1-C6)-acyl, R1 and R2, which may be identical or different, each represents independently of the other aryl, heteroaryl, or (C5-C7)-cycloalkyl, or one of those groups optionally substituted, A, together with the atoms in common with the pyrrole, represents saturated or unsaturated, monocyclic or bicyclic (C3-C12)-cycloalkyl, or a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen, or 7-oxabicyclo[2.2.1]heptane, or one of those groups optionally substituted, their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, pharmaceutical compositions thereof, and use thereof as medicaments.

公开(公告)号：AU7860898A

公开(公告)日：1999-02-11

申请号：AU7860898

申请日：1998-07-30

Applicant: SERVIER LAB

Inventor： NATEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  FRADIN ARMEL

IPC: C07D235/06 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61P29/00 ,  A61P43/00 ,  C07D235/12 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D521/00 ,  C07D403/10 ,  C07D417/10

公开(公告)号：AU3437695A

公开(公告)日：1996-05-02

申请号：AU3437695

申请日：1995-10-19

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  REMOND GEORGES ,  PORTEVIN BERNARD ,  BONNET JACQUELINE ,  CANET EMMANUEL ,  BIRRELL GRAHAM

IPC: A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04 ,  C07D401/14 ,  C07D409/14

公开(公告)号：DK1065209T3

公开(公告)日：2003-08-25

申请号：DK00401864

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle