公开(公告)号：CA2735485A1

公开(公告)日：2004-06-24

申请号：CA2735485

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN ,  PATEL SUMIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM

IPC: C07D473/18 ,  B01J20/26 ,  C07D473/12 ,  C07F7/08 ,  C07F7/18

Abstract: The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.

公开(公告)号：PL212790B1

公开(公告)日：2012-11-30

申请号：PL37726303

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN K ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07F7/08 ,  C07D473/12 ,  C07D473/18 ,  C07F7/18

公开(公告)号：PL377263A1

公开(公告)日：2006-01-23

申请号：PL37726303

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN K ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07F7/08 ,  C07D473/12 ,  C07D473/18 ,  C07F7/18