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1.发明申请PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES 审中-公开（S）-2-氨基-6,6-二甲氧基乙酸甲酯的制备通过新型二氧化物
公开(公告)号：WO0003981A8
公开(公告)日：2001-06-28
申请号：PCT/US9914957
申请日：1999-07-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GODFREY JOLLIE D JR , KRONENTHAL DAVID R , SCHWINDEN MARK D , SRIVASTAVA SUSHIL K , RAMIG KEITH , VENIT JOHN J , JASS PAUL A , RACHA SAIBABA , DILLON JOHN L JR , SOUNDARARAJAN NACHIMUTHU , POWERS GERALD L , KOTNIS ATUL S
IPC: A61K31/554 , A61P9/04 , A61P9/12 , A61P43/00 , C07C229/22 , C07D317/30 , C07D513/04 , C07D317/26 , C07D317/28
CPC classification number: C07C229/22 , C07D317/30
Abstract: The invention relates to the synthesis of 2-amino-6, 6-dimethoxy hexanoic acid, methyl ester and novel dioxalane intermediates thereof, from the reaction of glycinamide of formula I with dioxolane of formula II.
Abstract translation: 本发明涉及由式I的甘氨酰胺与式II的二氧戊环的反应合成2-氨基-6,6-二甲氧基己酸，甲酯和新的二氧杂环戊烷中间体。
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2.发明申请PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES 审中-公开（S）-2-氨基-6,6-二甲氧基己酸甲酯通过新型二氧化硅的制备
公开(公告)号：WO0003981A2
公开(公告)日：2000-01-27
申请号：PCT/US9914957
申请日：1999-07-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GODFREY JOLLIE D JR , KRONENTHAL DAVID R , SCHWINDEN MARK D , SRIVASTAVA SUSHIL K , RAMIG KEITH , VENIT JOHN J , JASS PAUL A , RACHA SAIBABA , DILLON JOHN L JR , SOUNDARARAJAN NACHIMUTHU , POWERS GERALD L , KOTNIS ATUL S
IPC: A61K31/554 , A61P9/04 , A61P9/12 , A61P43/00 , C07C229/22 , C07D317/30 , C07D513/04 , C07D
CPC classification number: C07C229/22 , C07D317/30
Abstract: The invention relates to the synthesis of 2-amino-6, 6-dimethoxy hexanoic acid, methyl ester and novel dioxalane intermediates thereof, from the reaction of glycinamide of formula I with dioxolane of formula II.
Abstract translation: 本发明涉及由式I的甘氨酰胺与式II的二氧戊环反应合成2-氨基-6,6-二甲氧基己酸，甲酯和其新二氧杂环戊烷中间体。
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公开(公告)号：EP1644384A4
公开(公告)日：2009-09-02
申请号：EP03812974
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR
IPC: C07D473/18 , C07D473/12 , C07F7/08 , C07F7/18
CPC classification number: C07F7/1856 , C07D473/18 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/0827 , C07F7/083
Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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公开(公告)号：EP1039890A4
公开(公告)日：2001-04-04
申请号：EP98960437
申请日：1998-12-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： TIMMINS PETER , WINTER WILLIAM J , SRIVASTAVA SUSHIL K , BRETNALL ALISON , WEI CHENKOU , POWERS GERALD L
IPC: A61K9/20 , A61K9/48 , A61K31/155 , A61K31/18 , A61K31/4965 , A61K45/06 , A61P3/10 , C07C279/26 , C07C55/10
CPC classification number: C07C279/26
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5.发明公开PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES 审中-公开HERSTELLUNG VON（S）-2-氨基-6,6-二甲氧基雄甾烷-G-甲酯通过NEUARTIGER二氧戊环
公开(公告)号：EP1121351A4
公开(公告)日：2003-05-02
申请号：EP99932163
申请日：1999-07-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GODFREY JOLLIE D JR , KRONENTHAL DAVID R , SCHWINDEN MARK D , SRIVASTAVA SUSHIL K , RAMIG KEITH , VENIT JOHN J , JASS PAUL A , RACHA SAIBABA , DILLON JOHN L JR , SOUNDARARAJAN NACHIMUTHU , POWERS GERALD L , KOTNIS ATUL S
IPC: A61K31/554 , A61P9/04 , A61P9/12 , A61P43/00 , C07C229/22 , C07D317/30 , C07D513/04 , C07D317/26 , C07D317/28
CPC classification number: C07C229/22 , C07D317/30
Abstract: The invention relates to the synthesis of 2-amino-6, 6-dimethoxy hexanoic acid, methyl ester and novel dioxalane intermediates thereof, from the reaction of glycinamide of formula I with dioxolane of formula II.
Abstract translation: 本发明涉及由式I的甘氨酰胺与式II的二氧戊环反应合成2-氨基-6,6-二甲氧基己酸，甲酯和其新二氧杂环戊烷中间体。
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Patent Agency Ranking6.发明公开NOVEL REACTION CONDITIONS FOR THE CLEAVAGE OF SILYL ETHERS IN THE PREPARATION OF PACLITAXEL (TAXOL$m(3)) AND PACLITAXEL ANALOGUES 有权新型反应条件的甲硅烷基醚的紫杉醇（TAXOL-M（3））和紫杉醇类似物的MAKING SPLIT
公开(公告)号：EP1178979A4
公开(公告)日：2002-06-12
申请号：EP00932151
申请日：2000-05-08
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： SINGH AMBARISH , WEAVER RAYMOND E JR , POWERS GERALD L , ROSSO VICTOR W
IPC: C07D305/14 , A61K31/337 , A61P35/00
CPC classification number: C07D305/14
Abstract: Novel reaction conditions for the cleavage of silyl ethers from silyl protected taxane precursors to afford paclitaxel and paclitaxel analogues in high yield and quality are described. Paclitaxel is prepared from a taxane precursor by treating the taxane precursor with a strong acid such as trifluoroacetic acid in a solvent such as aqueous acetic acid, such that the amount and number of side reactions and taxane impurities are significantly minimized. Also described are the crystallization methods for the isolation of paclitaxel in either of the two crystal forms A or B. Paclitaxel and paclitaxel analogues are anti-cancer agents.
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公开(公告)号：PL212790B1
公开(公告)日：2012-11-30
申请号：PL37726303
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN K , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , BANERJEE AMIT , KUCERA DAVID J
IPC: C07F7/08 , C07D473/12 , C07D473/18 , C07F7/18
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公开(公告)号：CA2312990C
公开(公告)日：2008-04-29
申请号：CA2312990
申请日：1998-12-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： WINTER WILLIAM J , TIMMINS PETER , POWERS GERALD L , BRETNALL ALISON , SRIVASTAVA SUSHIL K , WEI CHENKOU
IPC: A61K9/20 , A61K31/155 , A61K9/48 , A61K31/18 , A61K31/4965 , A61K45/06 , A61P3/10 , C07C279/26
Abstract: Novel salts of the antidiabetic agent metformin are provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employe d alone or in combination with another antihyperglycemic agent such as glyburide, for treating diabetes. A method for treating diabet es employing the novel metformin salt by itself or in combination with another antidiabetic agent is also provided.
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公开(公告)号：PL377263A1
公开(公告)日：2006-01-23
申请号：PL37726303
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN K , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , BANERJEE AMIT , KUCERA DAVID J
IPC: C07F7/08 , C07D473/12 , C07D473/18 , C07F7/18
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公开(公告)号：ES2216335T3
公开(公告)日：2004-10-16
申请号：ES98960437
申请日：1998-12-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： TIMMINS PETER , WINTER WILLIAM J , SRIVASTAVA SUSHIL K , BRETNALL ALISON , WEI CHENKOU , POWERS GERALD L
IPC: A61K9/20 , A61K9/48 , A61K31/155 , A61K31/18 , A61K31/4965 , A61K45/06 , A61P3/10 , C07C279/26 , C07C55/10
Abstract: Novel salts of the antidiabetic agent metformin acre provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employed alone or in combination with another antihyperglycemic agent such as glyburide, for treating diabetes. A method for treating diabetes employing the novel metformin salt by itself or in combination with another antidiabetic agent is also provided.
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