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公开(公告)号：EP1644384A4
公开(公告)日：2009-09-02
申请号：EP03812974
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR
IPC: C07D473/18 , C07D473/12 , C07F7/08 , C07F7/18
CPC classification number: C07F7/1856 , C07D473/18 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/0827 , C07F7/083
Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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公开(公告)号：PL397715A1
公开(公告)日：2012-03-26
申请号：PL39771503
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN K , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , BANERJEE AMIT , PATEL RAMESH N , KUCERA DAVID J
IPC: C07F7/08 , C07D473/12 , C07D473/18 , C07F7/18
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公开(公告)号：BR0317255A
公开(公告)日：2005-11-08
申请号：BR0317255
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： BANERJEE AMIT , KUCERA DAVID J , PENDRI YADAGIRI , CHEN CHUNG-PIN , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM
IPC: C07D473/12 , C07D473/18 , C07F7/08 , C07F7/18
Abstract: The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.
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公开(公告)号：ES2397104T3
公开(公告)日：2013-03-04
申请号：ES03812974
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI , CHEN CHUNG-PIN , PATEL SUNIL , EVANS JEFFREY , LIANG JING , KRONENTHAL DAVID , POWERS GERALD , PRASAD SIVA , BIEN JEFFREY , SHI ZHONGPING , PATEL RAMESH , CHAN YEUNG , RIJHWANI SUSHIL , SINGH AMBARISH , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , BANERJEE AMIT , KUCERA DAVID
IPC: C07D473/18 , C07D473/12 , C07F7/08 , C07F7/18
Abstract: Un procedimiento para preparar entecavir que tiene la fórmula que comprende: (a) tratar un éster de la fórmula en la que Ra es alilo, fenilo, alquilfenilo C1 a C6, o alcoxifenilo C1 a C6; Rb es alquilo C1 a C6; y R es alquilo C1 aC4 o bencilo; con un enol éter de acetona y un ácido para proteger el grupo hidroxi, seguido de tratamiento con un reactivo dehidruro para reducir el resto de éster de ácido carboxílico, y a continuación alquilar el alcohol resultante con unhaluro de bencilo y eliminar el grupo protector hidroxi enol éter para dar un alcohol alílico de la fórmula (b) epoxidar el producto de la etapa (a) con una epoxidación diastereoselectiva para dar un epóxido deciclopentano que tiene la fórmula (c) tratar el epóxido de ciclopentano de la etapa (b) con una sal de metal alcalino de un compuesto de purina defórmula
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公开(公告)号：DK1644384T3
公开(公告)日：2013-02-11
申请号：DK03812974
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , VEMISHETTI PURUSHOTHAM , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , BANERJEE AMIT , KUCERA DAVID J
IPC: C07D473/18 , C07D473/12 , C07F7/08 , C07F7/18
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Patent Agency Ranking
公开(公告)号：CA2508811A1
公开(公告)日：2004-06-24
申请号：CA2508811
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： KRISHNAMURTY DHILEEPKUMAR , THOTTATHIL JOHN , PENDRI YADAGIRI R , KRONENTHAL DAVID R , LEWIS CHARLES , POWERS GERALD L , PRASAD SIVA JOSYULA , VEMISHETTI PURUSHOTHAM , SHI ZHONGPING , BIEN JEFFREY T , ZHOU MAOTANG X , PATEL RAMESH N , CHEN CHUNG-PIN H , LIANG JING , RIJHWANI SUSHIL K , CHAN YEUNG Y , WANG SHAOPENG , SINGH AMBARISH K , STOJANOVIC MILAN , EVANS JEFFREY M , PATEL SUNIL S , POLNIASZEK RICHARD , BANERJEE AMIT , KUCERA DAVID J
IPC: C07D473/12 , C07D473/18 , C07F7/08 , C07F7/18
Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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公开(公告)号：CA2508811C
公开(公告)日：2014-11-18
申请号：CA2508811
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , KUCERA DAVID J , BANERJEE AMIT
IPC: C07F7/10 , C07C67/00 , C07D473/12 , C07D473/18 , C07F7/08 , C07F7/18
Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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公开(公告)号：SI1644384T1
公开(公告)日：2013-02-28
申请号：SI200332236
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , BANERJEE AMIT , KUCERA DAVID J
IPC: C07D473/00 , C07D473/12 , C07D473/18 , C07F7/00 , C07F7/08 , C07F7/18
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公开(公告)号：AU2003300884A1
公开(公告)日：2004-06-30
申请号：AU2003300884
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , VEMISHETTI PURUSHOTHAM , PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M
IPC: C07D473/12 , C07D473/18 , C07F7/08 , C07F7/18
Abstract: The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.
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公开(公告)号：PT1644384E
公开(公告)日：2013-01-23
申请号：PT03812974
申请日：2003-12-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： PATEL RAMESH N , VEMISHETTI PURUSHOTHAM , POWERS GERALD L , KRONENTHAL DAVID R , KUCERA DAVID J , CHEN CHUNG-PIN H , PENDRI YADAGIRI R , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR , ZHOU MAOTANG X , BANERJEE AMIT
IPC: C07D473/18 , C07D473/12 , C07F7/08 , C07F7/18
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